Solute Translocation Across the Lysosome Membrane: Physiology, Pathology and Pharmacology
Lysosomes were discovered, almost 40 years ago, because their limiting membrane is impermeable to certain low molecular weight solutes. 2-Phosphoglycerol is such a substance and, as it is also a substrate for lysosomal acid phosphatase, lysosomes incubated with 2-phosphoglycerol hydrolyse it only if their membrane is ruptured. De Duve has described in a number of publications how this initial observation led on to the characterization of lysosomes as a distinct class of subcellular organelles (see, for example, De Duve 1969 and 1979).
KeywordsPermeability Glutathione Ethyleneglycol Cysteine Lysine
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