Abstract
Lysosomes were discovered, almost 40 years ago, because their limiting membrane is impermeable to certain low molecular weight solutes. 2-Phosphoglycerol is such a substance and, as it is also a substrate for lysosomal acid phosphatase, lysosomes incubated with 2-phosphoglycerol hydrolyse it only if their membrane is ruptured. De Duve has described in a number of publications how this initial observation led on to the characterization of lysosomes as a distinct class of subcellular organelles (see, for example, De Duve 1969 and 1979).
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© 1989 Springer-Verlag Berlin Heidelberg
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Lloyd, J.B., Kooistra, T., Forster, S., Bird, S.J., Iveson, G.P. (1989). Solute Translocation Across the Lysosome Membrane: Physiology, Pathology and Pharmacology. In: Azzi, A., Drahota, Z., Papa, S. (eds) Molecular Basis of Membrane-Associated Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74415-0_33
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DOI: https://doi.org/10.1007/978-3-642-74415-0_33
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