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Neurofibromatosis Type 2: MR Evaluation and Clinical Correlation

  • J. L. Sherman
  • D. M. Parry
  • R. Eldridge
  • M. Kaiser-Kupfer
  • A. Pikus
  • C. M. Citrin
Conference paper

Abstract

The neurofibromatoses consists of at least two distinct autosomal dominant disorders with differing clinical manifestations (Martuza 1988; NIH 1988). Neurofibromatosis 1 (NF-1) was originally described by von Recklinghausen and was previously known as peripheral neurofibromatosis. Recently the gene has been assigned to chromosome 17. Neurofibromatosis 2 (NF-2), also known as central neurofibromatosis, is an autosomal dominant disorder, the hallmark of which is the presence of bilateral acoustic neuromas (AN). NF-2 has recently been assigned to chromosome 22. The affected persons generally become symptomatic in their teens or twenties with hearing loss or tinnitus as a result of the acoustic neuroma.

Keywords

Hearing Loss Normal Hearing Acoustic Neuroma Internal Auditory Canal Ophthalmological Evaluation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Martuza RL, Eldridge R (1988) Neurofibromatosis 2 (bilateral acoustic neurofibromatosis). N Engl J Med 318: 684–688PubMedCrossRefGoogle Scholar
  2. National Institutes of Health consensus development conference statement of neurofibromatosis (1988) Arch Neurol 45: 575–580CrossRefGoogle Scholar
  3. Pearson-Webb MA, Kaiser-Kupfer MI, Eldridge R (1986) Eye findings in bilateral acoustic (central) neurofibromatosis: association with presemle lens opacities and cataracts but absence of Lisch nodules. N Engl J Med 315: 1553–1554PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. L. Sherman
  • D. M. Parry
  • R. Eldridge
  • M. Kaiser-Kupfer
  • A. Pikus
  • C. M. Citrin

There are no affiliations available

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