Neurofibromatosis Type 2: MR Evaluation and Clinical Correlation

  • J. L. Sherman
  • D. M. Parry
  • R. Eldridge
  • M. Kaiser-Kupfer
  • A. Pikus
  • C. M. Citrin
Conference paper

Abstract

The neurofibromatoses consists of at least two distinct autosomal dominant disorders with differing clinical manifestations (Martuza 1988; NIH 1988). Neurofibromatosis 1 (NF-1) was originally described by von Recklinghausen and was previously known as peripheral neurofibromatosis. Recently the gene has been assigned to chromosome 17. Neurofibromatosis 2 (NF-2), also known as central neurofibromatosis, is an autosomal dominant disorder, the hallmark of which is the presence of bilateral acoustic neuromas (AN). NF-2 has recently been assigned to chromosome 22. The affected persons generally become symptomatic in their teens or twenties with hearing loss or tinnitus as a result of the acoustic neuroma.

Keywords

Neurol Cataract Photography Neurofibromatosis Neuroma 

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References

  1. Martuza RL, Eldridge R (1988) Neurofibromatosis 2 (bilateral acoustic neurofibromatosis). N Engl J Med 318: 684–688PubMedCrossRefGoogle Scholar
  2. National Institutes of Health consensus development conference statement of neurofibromatosis (1988) Arch Neurol 45: 575–580CrossRefGoogle Scholar
  3. Pearson-Webb MA, Kaiser-Kupfer MI, Eldridge R (1986) Eye findings in bilateral acoustic (central) neurofibromatosis: association with presemle lens opacities and cataracts but absence of Lisch nodules. N Engl J Med 315: 1553–1554PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. L. Sherman
  • D. M. Parry
  • R. Eldridge
  • M. Kaiser-Kupfer
  • A. Pikus
  • C. M. Citrin

There are no affiliations available

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