Uncoupling of the β-Adrenergic Receptor by Myocardial Ischemia

  • D. E. Vatner
Conference paper


Several prior studies, conducted in membrane preparations from animal models in which myocardial ischema was induced after general anesthesia and recent thoracotomy, have observed increased β-adrenergic receptor density in ischemic myocardium [1–6]. Since anesthesia and recent surgery alter the autonomic milieu induced by coronary artery occlusion and myocardial ischemia [7], the effect of myocardial ischemia on β-adrenergic receptor density and adenylate cyclase activity were examined in dogs in which myocardial ischemia was induced in the conscious state [6]. This report reviews the data from these studies [6] and proposes a mechanism responsible for the findings.


Adrenergic Receptor Adenylate Cyclase Activity Coronary Artery Occlusion Ischemic Zone Solid Column 
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© Springer-Verlag Berlin Heidelberg 1989

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  • D. E. Vatner

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