Uncoupling of the β-Adrenergic Receptor by Myocardial Ischemia
Several prior studies, conducted in membrane preparations from animal models in which myocardial ischema was induced after general anesthesia and recent thoracotomy, have observed increased β-adrenergic receptor density in ischemic myocardium [1–6]. Since anesthesia and recent surgery alter the autonomic milieu induced by coronary artery occlusion and myocardial ischemia , the effect of myocardial ischemia on β-adrenergic receptor density and adenylate cyclase activity were examined in dogs in which myocardial ischemia was induced in the conscious state . This report reviews the data from these studies  and proposes a mechanism responsible for the findings.
KeywordsAdrenergic Receptor Adenylate Cyclase Activity Coronary Artery Occlusion Ischemic Zone Solid Column
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