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Catecholamine-Dependent Cardiac Arrhythmias: Mechanisms and Implications

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Adrenergic System and Ventricular Arrhythmias in Myocardial Infarction

Abstract

Although the arrhythmogenic role of sympathetic activation acting over an ischemic substrate has been established [1, 2], the mechanisms involved remain largely speculative. In fact, due to their electrophysiologic properties, catecholamines influence several determinants of cardiac excitability thus creating a rather complex picture which is difficult to unravel. This complexity is largely due to the fact that adrenergic activation, besides acting on the electrophysiologic characteristics of the heart, affects most cardiac functions such as contractility, metabolism, and coronary circulation. Furthermore, depending on the substrate on which catecholamines are released, i.e., whether the heart is normally perfused or acutely ischemic or has suffered a myocardial infarction, the consequences of adrenergic activation can vary.

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Authors
  1. S. G. Priori
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  2. P. J. Schwartz
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Editor information

Editors and Affiliations

  1. Abteilung für Innere Medizin III, Kardiologie Medizinische Universitätsklinik, Bergheimer Straße 58, 6900, Heidelberg 1, Germany

    J. Brachmann  & A. Schömig  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Priori, S.G., Schwartz, P.J. (1989). Catecholamine-Dependent Cardiac Arrhythmias: Mechanisms and Implications. In: Brachmann, J., Schömig, A. (eds) Adrenergic System and Ventricular Arrhythmias in Myocardial Infarction. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74317-7_20

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  • DOI: https://doi.org/10.1007/978-3-642-74317-7_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74319-1

  • Online ISBN: 978-3-642-74317-7

  • eBook Packages: Springer Book Archive

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