DMSO Irritancy Assessed Using Noninvasive Methods

  • T. Agner
  • J. Serup
Conference paper


The dimethylsulfoxide (DMSO) test is a quick and reliable test of the barrier function of the skin. In this study, in order to quantify the response, the physiological components of the DMSO response are investigated using noninvasive methods.

Key words

Dimethylsulfoxide Electrical conductance Transepidermal water loss Laser Doppler flowmetry Ultrasound A scan 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Frosch P (1985) Hautirritation und empfindliche Haut. Grosse-Verlag, Berlin.Google Scholar
  2. 2.
    Frosch P, Duncan S, Kligman AM (1980) Cutaneous biometrics I. The response of human skin to dimethyl sulfoxide. Br J Dermatol 102: 263–274.Google Scholar
  3. 3.
    Blichmann CW, Serup J (1988) Assessment of skin moisture. Measurement of electrical conductance, capacitance and transepidermal water loss. Acta Derm Venereol (Stockh) (in press).Google Scholar
  4. 4.
    Tagami H, Yoshikuni K (1980) Evaluation of the hydration state of the stratum corneum in vivo by electrical measurement. J Invest Dermatol 75: 500–507.PubMedCrossRefGoogle Scholar
  5. 5.
    Blichmann C, Serup J (1987) Reproducibility and variability of transepidermal water loss measurement. Acta Derm Venereol (Stockh) 67: 206–210.Google Scholar
  6. 6.
    Tenland T (1982) On laser Doppier flowmetry. Linköping University medical dissertations no 136.Google Scholar
  7. 7.
    Serup J (1984) Localized scleroderma (Morphoea): thickness of sclerotic plaques as measured by 15 MHz pulsed ultrasound. Acta Derm Venereol (Stockh) 64: 214–219.Google Scholar
  8. 8.
    Malten KE (1978) Topical toxicity of various concentrations of DMSO recorded with impedance measurements and water vapour loss measurements. Contact Dermatitis 4: 80–92.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. Agner
    • 1
  • J. Serup
    • 1
  1. 1.Department of DermatologyRigshospitaletCopenhagenDenmark

Personalised recommendations