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Relationship Between Maternal Glucose Levels and Congenital Malformations in the Infant of the Diabetic Mother

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Diabetes Mellitus: Pathophysiology and Therapy

Part of the book series: Bayer AG Centenary Symposium ((BAYER))

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Abstract

Although there has been considerable improvement in the outcome of pregnancies complicated by diabetes [1–3], the incidence of congenital malformations in infants of diabetic mothers is still three times greater than the rate in the offspring of nondiabetic mothers [4–6]. Because the other problems associated with diabetic pregnancies, such as macrosomia, stillbirths, and intrauterine growth retardation, have been dramatically reduced, malformations have emerged as the most common cause of perinatal death among infants of diabetic women [7].

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References

  1. Jovanovic L, Druzin M, Peterson CM (1981) The effect of euglycemia on the outcome of pregnancy in insulin dependent diabetes as compared to normal controls. Am J Med 71: 921–927

    Article  PubMed  CAS  Google Scholar 

  2. Adashi EY, Pinto H, Tyson JE (1979) Impact of maternal euglycemia on fetal outcome in diabetic pregnancy. Am J Obstet Gynecol 133: 268–274

    PubMed  CAS  Google Scholar 

  3. Peacock I, Hunter JC, Walford S, Allison SP, Symonds EM, Tattersall RB (1979) Self–monitor¬ing of blood glucose in diabetic pregnancy. Br Med J 1333–1336

    Google Scholar 

  4. Duncan JM (1982) On puerperal diabetes. Trans Obstet Soc London 24: 256–285

    Google Scholar 

  5. Molsted-Pedersen L, Tygstrup I, Pedersen J (1966) Congenital malformations in newborn infants of diabetic women. Correlation with maternal diabetic vascular complications. Lancet I: 1124–1162

    Google Scholar 

  6. Pedersen J (1977) The pregnant diabetic and her newborn, 2nd edn. Copenhagen, Munksgaard, pp 1–280

    Google Scholar 

  7. Mills JL (1982) Malformations in infants of diabetic mothers. Teratology 25: 385–394

    Article  PubMed  CAS  Google Scholar 

  8. Eriksson UJ, Lewis NJ, Freinkel N (1984) Growth retardation during early organogenesis in embryos of experimentally diabetic rats. Diabetes 33: 281–284

    Article  PubMed  CAS  Google Scholar 

  9. Endo A (1966) Teratogenesis in diabetic mice treated with alloxan prior to conception. Arch Environ Health 12: 492–500

    PubMed  CAS  Google Scholar 

  10. Horii K, Watanabe G, Ingalls TH (1966) Experimental diabetes in pregnant mice: prevention of congenital malformations in offspring by insulin. Diabetes 15: 194–204

    PubMed  CAS  Google Scholar 

  11. Brownscheidle CM, Davies DL (1981) Diabetes in pregnancy: a preliminary study of the pan-creas, placenta and malformations in the BB Wistar rat. Placenta 33 (Suppl): 203–216

    Google Scholar 

  12. Deuchar EM (1977) Embryonic malformations in rats, resulting from maternal diabetes: preliminary observations. J Embryol Exp Morphol 41: 93–99

    PubMed  CAS  Google Scholar 

  13. Day R, Insley J (1976) Maternal diabetes and congenital malformations. Arch Dis Child 51: 935

    Article  PubMed  CAS  Google Scholar 

  14. Bennett PH, Webner C, Miller M (1979) Congenital anomalies and the diabetic and pre-diabetic pregnancy. Ciba Found Symp 63: 207

    Google Scholar 

  15. Marble A, Krall LP, Bradley RF et al. (eds) (1985) Joslin’s diabetes mellitus, 12th edn. Lea and Febiger, Philadelphia, pp 701–702

    Google Scholar 

  16. Kucera J (1971) Rate and type of congenital anomalies among offspring of diabetic women. J Reprod Med 7: 61

    Google Scholar 

  17. Pedersen J (1977) The pregnant diabetic and her newborn. Copenhagen, Munksgaard, p 194

    Google Scholar 

  18. Mills JL, Baker L, Goldman AS (1979) Malformations in infants of diabetic mothers occur before the seventh gestational week: implications for treatment. Diabetes 28: 292–293

    Article  PubMed  CAS  Google Scholar 

  19. Mills JL (1982) Malformations in infants of diabetic mothers. Teratology 24: 385

    Article  Google Scholar 

  20. Mills JL (1987) Congenital malformations in diabetes. Report of the 93rd Ross conference on pediatric research, pp 12–19

    Google Scholar 

  21. Hoet JJ (1986) The etiology of congenital malformations in the infants of the diabetic mother. In: Jovanovic L, Peterson CM (eds). Diabetes in pregnancy: teratology, toxicology and treatment. Praeger, Philadelphia, pp 72–82

    Google Scholar 

  22. Miller EM, Hare JW, Cloherty JR et al. (1981) Major congenital anomalies and elevated hemoglobin A1c in early weeks of diabetic pregnancy. N Engl J Med 304: 1331

    Article  PubMed  CAS  Google Scholar 

  23. Ylinen K, Aula P, Stenman U-H et al. (1984) Risk of minor and major fetal malformations in diabetics with high haemoglobin Alc values in early pregnancy. Br Med J 289: 345

    Article  CAS  Google Scholar 

  24. Reid M, Hadden D, Harley JMG, et al. (1984) Fetal malformations in diabetics with high haemoglobin A1c in early pregnancy, letter. Br Med J 289: 1001

    Article  CAS  Google Scholar 

  25. Goldman J A, Dicker D, Feldberg D, Yeshaya A, Samuel N, Karp M (1986) Pregnancy outcome in patients with insulin-dependent diabetes mellitus with preconceptional diabetic control: a comparative study. Am J Obstet Gynecol 155: 293–297

    PubMed  CAS  Google Scholar 

  26. Steel JM (1985) Prepregnancy counseling and contraception in the insulin-dependent diabetic patient. Clin Obstet Gynecol 28: 553–566

    Article  PubMed  CAS  Google Scholar 

  27. Fuhrmann K, Reiher H, Semmler K et al. (1983) Prevention of congenital malformations in infants of insulin-dependent diabetic mothers. Diabetes Care 6: 219

    Article  PubMed  CAS  Google Scholar 

  28. Fuhrmann K, Reiher H, Semmler K et al. (1984) The effect of intensified conventional insulin therapy before and during pregnancy on the malformation rate in offspring of diabetic mothers. Exp Clin Endocrinol 83: 173

    Article  PubMed  CAS  Google Scholar 

  29. Mills JL, Fishl AR, Knopp RH et al. (1983) Malformations in infants of diabetic mothers: problems in study design. Prev Med 12: 274–286

    Article  PubMed  CAS  Google Scholar 

  30. Mils JL, Knopp RH, Simpson JL, Jovanovic–Peterson L et al. (1988) Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis. N Engl J Med 318: 671–667

    Article  Google Scholar 

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© 1989 Springer-Verlag Berlin Heidelberg

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Jovanovic-Peterson, L., Peterson, C.M. (1989). Relationship Between Maternal Glucose Levels and Congenital Malformations in the Infant of the Diabetic Mother. In: Creutzfeldt, W., Lefèbvre, P.J. (eds) Diabetes Mellitus: Pathophysiology and Therapy. Bayer AG Centenary Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74255-2_24

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  • DOI: https://doi.org/10.1007/978-3-642-74255-2_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50506-8

  • Online ISBN: 978-3-642-74255-2

  • eBook Packages: Springer Book Archive

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