Abstract
The liver, in contrast to other organs such as the kidney, is able to extract highly protein-bound compounds. This is related to the particular structure of the liver “capillaries”, the sinusoids. The endothelial lining cell carries sieve-plates with fenestrations permitting exchange of high molecular weight compounds including proteins between the intravascular (sinusoidal) and extravascu1ar space, the space of Disse. The characteristics of these sieve-plates have been assessed by morphometric means by different authors (Wisse et al., 1983; Horn et al., 1986). The average diameter of these fenestrations is 105 and 175 nm, when assessed by scanning and transmission elecron microscopy, respectively; it decreases slightly along the acinus, while the number of fenstrations per square micron increases from 9 to 13 (Wisse et al., 1985). The number and/or diameter of these fenestrations is subject to regulation by different factors (Table 1) including pressure (Nopanitaya et al., 1976, Fraser et al., 1980), alcohol (Mak and Lieber, 1984; Horn et al., 1987), carbon tetrachloride (Okazaki et al., 1973), hypoxia, serotonin, norepinephrine, and cytochalasin B (Stefan et al. 1987).
Keywords
- Cirrhotic Liver
- Stepwise Logistic Regression Analysis
- Extravascular Space
- Intrahepatic Shunting
- Indicator Dilution Curve
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1989 Springer-Verlag Berlin Heidelberg
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Reichen, J. (1989). Hepatic Spaces and Transport in the Perfused Liver. In: Petzinger, E., Kinne, R.K.H., Sies, H. (eds) Hepatic Transport of Organic Substances. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74247-7_6
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DOI: https://doi.org/10.1007/978-3-642-74247-7_6
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