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Metabolism of Thyroid Hormone in Liver

  • T. J. Visser
  • M. Rutgers
  • W. W. de Herder
  • S. J. Eelkman Rooda
  • M. P. Hazenberg
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

The thyroid gland produces predominantly the prohormone thyroxine (T4) together with a small amount of the biologically active hormone 3,3′,5-triiodothyronine (T3). In normal humans and rats 80% of circulating T3 is derived from outer ring deiodination (ORD) of T4 in peripheral tissues. T3 is further degraded by inner ring deiodination (IRD) to 3,3′-T2. T4 and T3 are also metabolized by glucuronide (G) and sulfate (S) conjugation.

Keywords

Thyroid Hormone Peripheral Tissue Active Hormone Biliary Excretion Intestinal Bacterium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. J. Visser
    • 1
  • M. Rutgers
    • 1
  • W. W. de Herder
    • 1
  • S. J. Eelkman Rooda
    • 1
  • M. P. Hazenberg
    • 1
  1. 1.Departments of Internal Medicine III and Medical MicrobiologyErasmus University Medical SchoolRotterdamThe Netherlands

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