Metabolism of Thyroid Hormone in Liver

  • T. J. Visser
  • M. Rutgers
  • W. W. de Herder
  • S. J. Eelkman Rooda
  • M. P. Hazenberg
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

The thyroid gland produces predominantly the prohormone thyroxine (T4) together with a small amount of the biologically active hormone 3,3′,5-triiodothyronine (T3). In normal humans and rats 80% of circulating T3 is derived from outer ring deiodination (ORD) of T4 in peripheral tissues. T3 is further degraded by inner ring deiodination (IRD) to 3,3′-T2. T4 and T3 are also metabolized by glucuronide (G) and sulfate (S) conjugation.

Keywords

Thyroxine Triiodothyronine Propylthiouracil Iodothyronine 

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. J. Visser
    • 1
  • M. Rutgers
    • 1
  • W. W. de Herder
    • 1
  • S. J. Eelkman Rooda
    • 1
  • M. P. Hazenberg
    • 1
  1. 1.Departments of Internal Medicine III and Medical MicrobiologyErasmus University Medical SchoolRotterdamThe Netherlands

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