The Passage of Molecules into Bile: Paracellular and Transcytotic Pathways

  • W G M Hardison
  • P J Lowe
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Early observations that entry of certain inert solutes into bile was restricted gave rise to the concept of bile/plasma permeability barrier (Forker, 1968). The situation was analogous to that in the capillary which had received scrutiny by such eminent physiologists as Landis, Pappenheimer and Zweifach, to name a few. The capillary wall was viewed as containing static pores with degree of solute filtration depending upon hydrostatic pressure, fluid viscosity, surface area, solute concentration and size, shape and physical properties of the solute (Pappenheimer, 1953). The capillary itself was passive. This basic theory was later modified slightly by Grotte (1956) who postulated a small number of large pores to account for the finite permeability of macromolecules.


Tight Junction Bile Flow Paracellular Permeability Bile Formation Junctional Permeability 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • W G M Hardison
    • 1
    • 2
  • P J Lowe
    • 1
    • 2
  1. 1.Department of Medicine (111-D)VA Medical CenterUSA
  2. 2.University of CaliforniaSan DiegoUSA

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