The Ontogeny of Hepatic Bile Acid Transport
Bile formation is an extraordinarily complex process that requires the participation of numerous transport mechanisms for organic and inorganic anions on the sinusoidal and canalicular domains of the hepatocyte plasma membrane. The vectorial transport of bile acids from sinusoidal blood into bile requires the polarized insertion of specific transport proteins into the basolateral and apical domains of the plasma membrane. Recent studies indicate that the carrier mechanisms for bile acids are ontogenically regulated and expressed at very specific times during perinatal development. These findings are consistent with observations in the intact animal showing that bile secretory function is immature at birth and develops during postnatal life (Suchy et al., 1987). In addition, hepatic uptake and elimination of bile acids and other organic anions are decreased in developing animals including the human compared with the adult.
KeywordsHydrolysis Adenosine Polypeptide Polyacrylamide Alanine
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- Bellerman P (1981) Amino acid transport and rubidium-ion uptake in monolayer cultures of hepatocytes from neonatal rats. Biochem J 198: 475–483Google Scholar
- Novak DA, Suchy FJ (1987) Postnatal expression of the canalicular bile acid transport system in rat liver. Hepatology 7: 1037 (Abstract)Google Scholar
- Piccoli DA, Muller ER, Vanderslice RR (1986) Maturation of biliary steady state uptake and secretion capacity in the perfused rat liver. Hepatology 5: 1185 (Abstract)Google Scholar
- Ricour C, Rey J (1972) Study of the hydrolysis and micellar solubilization of fats during intestinal perfusion. I. Results in the normal child. Europ J Clin Biol Res 17: 172–178Google Scholar
- Suchy FJ, Ananthanarayanan M, Bucuvalas JC, Osadchey B, Yamada T, Belknap W, Balistreri W, Kaplowitz N (1988) An antibody to a developmentally regulated 48 kDa liver plasma protein inhibits taurocholate by isolated rat hepatocytes. Gastroenterology 94: A596 (Abstract)Google Scholar