The Ontogeny of Hepatic Bile Acid Transport
Bile formation is an extraordinarily complex process that requires the participation of numerous transport mechanisms for organic and inorganic anions on the sinusoidal and canalicular domains of the hepatocyte plasma membrane. The vectorial transport of bile acids from sinusoidal blood into bile requires the polarized insertion of specific transport proteins into the basolateral and apical domains of the plasma membrane. Recent studies indicate that the carrier mechanisms for bile acids are ontogenically regulated and expressed at very specific times during perinatal development. These findings are consistent with observations in the intact animal showing that bile secretory function is immature at birth and develops during postnatal life (Suchy et al., 1987). In addition, hepatic uptake and elimination of bile acids and other organic anions are decreased in developing animals including the human compared with the adult.
KeywordsBile Acid Plasma Membrane Vesicle Canalicular Membrane Bile Formation Bile Acid Transport
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