Transforming Growth Factor-Beta: Possible Roles in Carcinogenesis
Transforming growth factor “-beta” (TGF-ß) is a multifunctional regulator of cell growth and differentiation which exhibits context dependent biological effects. Thus, in vitro, TGF-ß can stimulate or inhibit proliferation, promote or block differentiation, and modulate cellular function depending on the cell type and cell environment (Roberts et al. 1988a; Sporn and Roberts 1988). Structurally, the active form of TGF-ß is a disulfide crosslinked homodimer with a molecular weight of 25 kDa in the unreduced form, with each monomer being 112 amino acids. TGF-ß is synthesized as a 390 amino acid precursor of which the mature peptide comprises the carboxyl terminal sequence (Derynck et al. 1985). This precursor sequence is very important for proper folding and disulfide bond formation of TGF-ß to ultimately generate a biologically active molecule.
KeywordsMigration Agar Urea Carboxyl Serine
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