Active Specific Immunotherapy of Colorectal Cancer

  • H. C. HooverJr.
  • M. G. HannaJr.

Abstract

In spite of improvements in surgical approaches, colorectal cancer patients with transmural extension of tumor and/or metastases to regional lymph nodes still have 5-year survival rates of only 20%–50% when treated by operative resection alone. Adjuvant radiation therapy can lower the incidence of local recurrence in rectal cancer, but does not control systemic metastasis. Toxicity and drug resistance continue to limit the usefulness of chemotherapy, although some benefit is suggested in a recent study (Wolmark et al. 1988).

Keywords

Placebo Toxicity Bacillus Cyclophosphamide Phosphamide 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. C. HooverJr.
    • 1
  • M. G. HannaJr.
    • 2
  1. 1.Surgical Oncology Research Massachusetts General Hospital BostonUSA
  2. 2.Bionetics Research Inc.RockvilleUSA

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