Skip to main content
SpringerLink
Log in

Peptides in Hypertension

  • Chapter
Pharmacology of Antihypertensive Therapeutics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 93 / 1))

  • 160 Accesses

Abstract

It is now well-established that blood pressure control is exerted by the concerted action of hormonal, renal, vascular, and neural mechanisms and that a variety of substances differing in chemical nature are involved in the mediation of these effects. Peptides have been among the first implicated in considerations concerned with the pathogenesis of hypertension.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aalkjaer C, Mulvany MJ, Nyborg NCB (1985) Atrial natriuretic factor causes specific relaxation of rat renal arcuate arteries. Br J Pharmacol 86: 447–453

    PubMed  CAS  Google Scholar 

  • Adrian TE, Allen JM, Bloom SR, Ghatei MA, Rosser MN, Roberts GW, Crow TJ, Tatemoto K, Polak JM (1983a) Neuropeptide distribution in human brain. Nature 306: 584–586

    PubMed  CAS  Google Scholar 

  • Agnati LF, Fuxe K, Benfenati F, Celani MF, Battistini N et al. (1983) Differential modulation by CCK-8 and CCK-4 of [3H]spiperone binding sites linked to dopamine and 5-hydroxytryptamine receptors in the brain of the rat. Neurosci Lett 35: 179–183

    PubMed  CAS  Google Scholar 

  • Allen JM, Adrian TE, Tatemoto K, Polak JM, Hughes J, Bloom SR (1982) Two novel related peptides, neuropeptide Y (NPY) and peptide YY ( PYY) inhibit the contraction of the electrically stimulated mouse vas deferens. Neuropeptides 3: 71–77

    Google Scholar 

  • Allen JM, Bircham PMM, Edwards AV, Tatemoto K, Bloom SR (1983) Neuropeptide Y ( NPY) reduces myocardial perfusion and inhibits the force of contraction of the isolated perfused rabbit heart. Regul Pept 6: 247–253

    Google Scholar 

  • Allen JM, Polak JM, Rodrigo J, Darcy K, Bloom SR (1985) Localisation of neuropeptide Y in nerves of the rat cardiovascular system and the effect of 6-hydroxydopamine. Cardiovasc Res 19: 570–577

    PubMed  CAS  Google Scholar 

  • Allen JM, Gjorstrup P, Bjorkman JA, Ek L, Abrahamsson T, Bloom SR (1986) Studies on cardiac distribution and function of neuropeptide Y. Acta Physiol Scand 126: 405–411

    PubMed  CAS  Google Scholar 

  • Allen JM, Novotny J, Martin J, Heinrich G (1987a) Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue. Proc Natl Acad Sci USA 84: 2532–2536

    PubMed  CAS  Google Scholar 

  • Allen JM, Yeats JC, Causon R, Brown MJ, Bloom SR (1987b) Neuropeptide Y and its flanking peptide in human endocrine tumors plasma. J Clin Endocrinol Metab 64: 1199–1204

    PubMed  CAS  Google Scholar 

  • Allen YS, Adrian TE, Allen JM, Tatemoto K, Crow TJ, Bloom SR, Polak JM (1983) Neuropeptide Y distribution in rat brain. Science 221: 877–879

    PubMed  CAS  Google Scholar 

  • Almeida FA, Suzuki M, Maack T (1986) Atrial natriuretic factor increases hematocrit and decreases plasma volume in nephrectomized rats. Life Sci 39: 1193–1199

    PubMed  CAS  Google Scholar 

  • Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM (1982) Alternative RNA processing in calcitonin gene expression generates mRNA’s encoding different polypeptide products. Nature 298: 240–243

    PubMed  CAS  Google Scholar 

  • Anderson JV, Donckier J, McKenna WJ, Bloom SR (1986) The plasma release of atrial natriuretic peptide in man. Clin Sci 71: 151–155

    PubMed  CAS  Google Scholar 

  • Anderson JV, Donckier J, Payne NN, Beacham J, Slater JDH, Bloom SR (1987) Atrial natriuretic peptide: evidence of action as a natriuretic hormone at physiological plasma concentrations in man. Clin Sci 72: 305–312

    PubMed  CAS  Google Scholar 

  • Atarashi K, Mulrow PJ, Franco–Saenz R (1985) Effect of atrial peptides on aldosterone production. J Clin Invest 76: 1807–1811

    CAS  Google Scholar 

  • Auguet M, Delaflotte S, Chabrier P-E, Pirotzky E, Clostre F, Braquet P (1988) Endothelin and Ca++ agonist Bay K 8644: different vasoconstrictive properties. Biochem Biophys Res Commun 156: 186–192

    PubMed  CAS  Google Scholar 

  • Bianchi C, Gutkowska J, Thibault G, Garcia R, Genest J, Cantin M (1985) Radioautographic localization of 125I-atrial natriuretic factor ( ANF) in rat tissues. Histochemistry 82: 441–452

    Google Scholar 

  • Biollaz J, Nussberger J, Porchet M, Brunner-Ferber F, Otterbein E, Gomez H, Waeber B, Brunner HR (1986) Four-hour infusions of synthetic atrial natriuretic peptide in normal volunteers. Hypertension 8: 1196–11105

    Google Scholar 

  • Blundell TL, Pitts JE, Tickle IJ, Wood SP, Wu CW (1981) X-ray analysis of avian pancreatic polypeptide: small globular protein hormone. Proc Natl Acad Sci USA 78: 4175–4179

    PubMed  CAS  Google Scholar 

  • Brain SD, Williams TJ, Tippins JR, Morris HR, Maclntyre I (1985) Calcitonin generelated peptide is a potent vasodilator. Nature 313: 54–56

    PubMed  CAS  Google Scholar 

  • Brain SD, Williams TJ (1988) Substance P regulates the vasodilutor activity of calcitonin gene–related peptide. Nature 335: 73–75

    PubMed  CAS  Google Scholar 

  • Breuhaus BA, Saneii HH, Brandt MA, Chimoskey JE (1985) Atriopeptin II lowers cardiac output in conscious sheep. Am J Physiol 249: R776–R780

    PubMed  CAS  Google Scholar 

  • Briggs JP, Steipe B, Schubert G, Schnermann J (1982) Micropuncture studies of the renal effects of atrial natriuretic substance. Pflügers Arch 395: 271–276

    PubMed  CAS  Google Scholar 

  • Burnett JC Jr, Granger JP, Opgenorth TS (1984) Effects of synthetic atrial natriuretic factor on renal function and renin release. Am J Physiol 247: F863–F866

    PubMed  CAS  Google Scholar 

  • Bussien JP, Biollaz J, Waeber B, Nussberger J, Turini GA, Brunner HR, Brunner-Ferber F, Gomez HJ, Otterbein ES (1986) Dose-dependent effect of atrial natriuretic peptide on blood pressure, heart rate, and skin blood flow of normal volunteers. J Cardiovasc Pharmacol 8: 216–220

    PubMed  CAS  Google Scholar 

  • Carter DA, Vallejo M, Lightman SL (1985) Cardiovascular effects of neuropeptide Y in the nucleus tractus solitarius of rats: relationship with noradrenaline and vasopressin. Peptides 6: 421–425

    PubMed  CAS  Google Scholar 

  • Chang RSL, Lotti VL, Chen T, Cerino DJ Kling PJ (1985) Neuropeptide Y (NPY) binding sites in rat brain labelled with i25J-Bolton-Hunter NPY: comparative potencies of various polypeptides on brain NPY binding and biological responses in the rat vas deferens. Life Sei 37: 2111–2122

    CAS  Google Scholar 

  • Chartier L, Schiffrin E, Thibault G, Garcia R (1984) Atrial natriuretic factor inhibits the stimulation of aldosterone secretion by angiotensin II, ACTH and potassium in vitro and angiotensin II-induced steroidogenesis in vivo. Endocrinology 115: 2026–2028

    Google Scholar 

  • Cocks TM, Angus JA (1983) Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature 305: 627–630

    PubMed  CAS  Google Scholar 

  • Cody RJ, Atlas SA, Laragh JH et al. (1986) Atrial natriuretic factor in normal subjects and heart failure patients. J Clin Invest 78: 1362–1374

    PubMed  CAS  Google Scholar 

  • Cohen ML, Schenck KW (1984) Atriopeptin II: differential sensitivity of arteries and veins from the rat. Eur J Pharmacol 108: 103–104

    Google Scholar 

  • Dahlöf C, Dahlöf P, Lundberg JM (1985a) Neuropeptide Y (NPY): Enhancement of blood pressure increase upon a-adrenoceptor activation and direct pressor effects in pithed rats. Eur J Pharmacol 109: 289–292

    Google Scholar 

  • Dahlöf C, Dahlöf P, Tatemoto K, Lundberg JM (1985b) Neuropeptide Y ( NPY) reduces field stimulation evoked release of noradrenaline and enhances force of contraction in the rat portal vein. Naunyn Schmiedeberg’s Arch Pharmacol 328: 327–330

    Google Scholar 

  • Dahlöf P, Persson K, Lundberg JM, Dahlöf C (1988) Neuropeptide Y ( NPY) induced inhibition of preganglionic nerve stimulation evoked release of adrenalin and noradrenaline in the pithed rat. Acta Physiol Scand 132: 51–57

    Google Scholar 

  • Day ML, Schwartz D, Rodi C, Rankin A, Needleman P, Wiegand R (1986) Enhanced atriopeptin mRNA and immunoreactivity in atria and ventricles treated with dexamethasone. Fed Proc 45: 601–607

    Google Scholar 

  • De Bold AJ, Borenstein HB, Veress AT, Sonnenberg H (1981) A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sei 28: 89–94

    Google Scholar 

  • De Lean A, Racz K, Gutkowska J, Nguyen TT, Cantin M, Genest J (1984) Specific receptor-mediated inhibition by synthetic atrial natriuretic factor of hormone–stimulated steroidogenesis in cultured bovine adrenal cells. Endocrinology 115: 1636–1638

    PubMed  Google Scholar 

  • De Lean A, Vinay P, Cantin M (1985) Distribution of atrial natriuretic factor receptors in dog kidney fractions. FEBS Lett 193: 239

    PubMed  Google Scholar 

  • De Mey JG, Vanhoutte PM (1983) Anoxia and endothelium-dependent reactivity of the canine femoral artery. J Physiol (Lond) 335: 65–74

    Google Scholar 

  • De Mey JG, Claeys M, Vanhoutte PM (1982) Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery. J Pharmacol Exp Ther 222: 166–173

    PubMed  Google Scholar 

  • De Nucci G, Thomas R, D’Orleans-Juste P, Antunes E, Walder C, Warner TD, Vane JR (1988) Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci USA 85: 9797–9800

    PubMed  Google Scholar 

  • De Quidt ME, Emson PC (1986) Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system—II. Immunohistochemical analysis. Neuroscience 18: 545–618

    Google Scholar 

  • Dietz JR (1984) Release of natriuretic factor from heart–lung preparation by atrial distension. Am J Physiol 247: R1093–R1096

    PubMed  CAS  Google Scholar 

  • Edvinsson L, Ekblad E, Hakanson R, Wahlestedt C (1984) Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br J Pharmacol 83: 519–525

    PubMed  CAS  Google Scholar 

  • Edvinsson L, Fredholm B, Hamel E, Janssen I, Verechia C (1985) Perivascular peptides relax cerebral arteries concomittant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat. Neurosci Lett 58: 213–217

    PubMed  CAS  Google Scholar 

  • Edvinsson L, Hakanson R, Wahlestedt C, Uddman R (1987) Effects of neuropeptide Y on the cardiovascular system. Trends Pharmacol Sci 8: 231–235

    CAS  Google Scholar 

  • Ekblad E, Edvinsson L, Wahlestedt C, Uddman R, Hakanson R, Sundler F (1984) Neuropeptide Y co-exists and co–operates with noradrenaline in perivascular nerve fibers. Regul Pept 8: 225–235

    PubMed  CAS  Google Scholar 

  • Emson PC, de Quidt ME (1984) NPY—a new member of the pancreatic polypeptide family. Trends Neurol Sci 7: 1–4

    Google Scholar 

  • Ensinger H, Hedler L, Schurr C, Starke K (1984) Ethyletocyclazocine decreases noradrenaline release and blood pressure in the rabbit at a peripheral opioid receptor. Naunyn–Schmiedeberg’s Arch Pharmacol 328: 20–23

    PubMed  CAS  Google Scholar 

  • Eskay R, Zukowska-Grojec Z, Haass M, Dave JR, Zamir N (1986) Circulating atrial natriuretic peptides in conscious rats: regulation of release by multiple factors. Science 232: 636–639

    PubMed  CAS  Google Scholar 

  • Everitt BJ, Hokfelt T, Terenius L, Tatemoto K, Mutt V, Goldstein M (1983) Differential coexistence of neuropeptide Y ( NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience 11: 443–462

    Google Scholar 

  • Faison EP, Siegl PKS, Morgan G, Winquist RJ (1985) Regional vasorelaxant selectivity of atrial natriuretic factor in isolated rabbit vessels. Life Sci 37: 1073–1079

    PubMed  CAS  Google Scholar 

  • Fisher LA, Kikkawa DO, Rivier JE, Amara R, Rosenfeld MG, Vale WW, Brown MR (1983) Stimulation of noradrenergic sympathetic outflow by calcitonin gene–related peptide. Nature 305: 534–536

    PubMed  CAS  Google Scholar 

  • Flynn TG, de Bold ML, de Bold AJ (1983) The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties. Biochem Biophys Res Commun 117: 859–865

    CAS  Google Scholar 

  • Fontaine B, Klarsfeld A, Changeux J-P (1987) Calcitonin gene related peptide and muscle activity regulate acetylcholine receptor a–subunit mRNA levels by distinct intracellular pathways. J Cell Biol 105: 1337–1342

    PubMed  CAS  Google Scholar 

  • Foster GV, Byfield PGH, Gudmunsson TV (1972) Calcitonin. Clin Endocrinol Metab 1: 93–101

    Google Scholar 

  • Franco-Cereceda A, Lundberg JM (1985) Calcitonin gene-related peptide ( CGRP) and capsaicin–induced stimulation of heart contractile rate and force. Naunyn-Schmiedeberg’s Arch Pharmacol 331: 146–151

    Google Scholar 

  • Franco-Cereceda A, Lundberg JM (1987) Potent effects of neuropeptide Y and calcitonin gene–related peptide on human coronary vascular tone in vitro. Acta Physiol Scand 131: 159–160

    PubMed  CAS  Google Scholar 

  • Franco-Cereceda A, Bengtsson L, Lundberg JM (1987a) Inotropic effects of calcitonin gene–related peptide, vasoactive intestinal polypetide and somatostatin on the human right atrium in vitro. Eur J Pharmacol 134: 69–76

    PubMed  CAS  Google Scholar 

  • Franco-Cereceda A, Henke H, Lundberg JM, Petermann JB, Hökfelt T, Fischer JA (1987c) Calcitonin gene–related peptide (CGRP) in capsaicin–sensitive substance P–immunoreactive sensory neurons in animals and man: distribution and release by capsaicin. Peptides 8: 399–410

    PubMed  CAS  Google Scholar 

  • Freeman RH, Davis JO, Vari RC (1985) Renal response to atrial natriuretic factor in conscious dogs with caval constriction. Am J Physiol 248: R495–R500

    PubMed  CAS  Google Scholar 

  • Fukuda Y, Hirata Y, Yoshimi H, Kojima T, Kobayashi Y, Yanagisawa M, Masaki T (1988) Endothelin is a potent secretagogue for arterial natriuretic peptide in cultured rat atrial myocytes. Biochem Biophys Res Commun 155: 167–172

    PubMed  CAS  Google Scholar 

  • Fuller F, Porter JG, Arfsten AE, Miller J, Schilling JW, Scarborough RM, Lewicki JA, Schenk DB (1988) Atrial natriuretic peptide clearance receptor: complete sequence and functional expression of cDNA clones. J Biol Chem 263: 9395–9401

    PubMed  CAS  Google Scholar 

  • Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373–376

    PubMed  CAS  Google Scholar 

  • Fuxe K, Agnati LF, Härfstrand A, Zini I, Tatemoto K, Pich EM, Hökfelt T (1983) Central administration of neuropeptide Y induces hypotension, bradypnoe and EEG synchronization in the rat. Acta Physiol Scand 118: 189–192

    PubMed  CAS  Google Scholar 

  • Ganten D, Minnich JL, Granger P, Hayduk K, Brecht HM, Barbeau A, Boucher R, Genest J (1971) Angiotensin–forming enzyme in brain tissue. Science 173: 64–65

    PubMed  CAS  Google Scholar 

  • Ganten D, Hermann K, Bayer C, Unger T, Lang RE (1983) Angiotensin Synthesis in the brain and increased turnover in hypertensive rats. Science 221: 869–871

    PubMed  CAS  Google Scholar 

  • Ganten D, Lang RE, Lehmann E, Unger T (1984) Commentary; Brain angiotensin: on the way to becoming a well-studied neuropeptide system. Biochem Pharmacol 33 (22): 3523–3528

    PubMed  CAS  Google Scholar 

  • Garcia R, Thibault G, Cantin M, Genest J (1984) Effect of a purified atrial natriuretic factor on rat and rabbit vascular strips and vascular beds. Am J Physiol 247: R34–R39

    PubMed  CAS  Google Scholar 

  • Garcia R, Thibault G, Gutkowska J, Horky K, Hamet P, Cantin M, Genest J (1985a) Chronic infusion of low doses of atrial natriuretic factor (ANF arg 101-tyr 126) reduces blood pressure in conscious SHR without apparent changes in sodium excretion. Proc Soc Exp Biol Med 179: 396–401

    PubMed  CAS  Google Scholar 

  • Garcia R, Thibault G, Seidah NG, Lazure C, Cantin M, Genest J, Chretien M (1985b) Structure-activity relationships of atrial natriuretic factor (ANF) II. Effect of chainlength modifications on vascular reactivity. Biochem Biophys Res Commun 126: 178–184

    Google Scholar 

  • Gardner DG, Deschepper CF, Ganong WF, Hane S, Fiddes J, Baxter JD, Lewicki J (1986) Extra-atrial expression of the gene for atrial natriuretic factor. Proc Natl Acad Sei USA 83: 6697–6701

    CAS  Google Scholar 

  • Gellai M, DeWolf RE, Kiner LB, Beeuwkes R III (1986) The effect of atrial natriuretic factor on blood pressure, heart rate, and renal functions in conscious, spontaneously hypertensive rats. Circ Res 59: 56–62

    PubMed  CAS  Google Scholar 

  • Gerstheimer FP, Metz J (1986) Distribution of calcitonin gene related peptide–like immunoreactivity in the guinea pig heart. Anat Embryol (Berl) 175: 255–260

    CAS  Google Scholar 

  • Gillespie MN, Owasoyo JO, McMurtry IF, O’Brien RF (1986) Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture. J Pharmacol Exp Ther 236: 339–343

    PubMed  CAS  Google Scholar 

  • Glover ID, Bartlow DI, Pitts JE, Wood SP, Tickle IJ, Blunde’ll TL, Tatemoto K, Kimmel JR, Wollmer A, Strassburger W, Zhang Y (1985) Conformational studies on the pancreatic polypeptide hormone family. Eur J Biochem 142: 379–385

    Google Scholar 

  • Goetz KL, Wang BC, Madwed JB, Zhu JL, Leadley RJ Jr (1988) Cardiovascular, renal, and endocrine responses to intravenous endothelin in conscious dogs. Am J Physiol 255: R1064–R1068

    PubMed  CAS  Google Scholar 

  • Goodfriend TL, Elliott M, Atlas SA (1984) Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa. Life Sei 35: 1675–1682

    CAS  Google Scholar 

  • Gu J, Polak JM, Allen JM, Huang WM, Sheppard MN, Tatemoto K, Bloom SR (1984) High concentrations of a novel peptide, neuropeptide Y, in the innervation of mouse and rat heart. J Histochem Cytochem 32: 467–472

    PubMed  CAS  Google Scholar 

  • Gutkowska J, Kuchel O, Racz K, Buu NT, Cantin M, Genest J (1986) Increased plasma immunoreactive atrial natriuretic factor concentrations in salt sensitive Dahl rats. Biochem Biophys Res Commun 136: 411–416

    PubMed  CAS  Google Scholar 

  • Haass M, Skofitsch G (1985) Cardiovascular effects of calcitonin gene–related peptide in the pithed rat: comparison with substance P. Life Sci 37: 2085–2090

    PubMed  CAS  Google Scholar 

  • Haass M, Zamir N, Zukowska-Grojec Z (1986) Plasma levels of atrial natriuretic peptides in conscious adult spontaneously hypertensive rats. Clin Exp Hypertens [A] 8: 277–287

    CAS  Google Scholar 

  • Hackenthal E, Aktories K, Jakobs KH, Lang RE (1987) Neuropeptide Y inhibits renin release by a pertussis toxin–sensitive mechanism. Am J Physiol 252: F543–F550

    PubMed  CAS  Google Scholar 

  • Haggblad J, Fredholm BB (1987) Adenosine and neuropeptide Y enhance aradrenoceptor-induced accumulation of inositol phosphate and attenuate forskolin-induced accumulation of cyclic AMP in rat vas deferens. Neurosci Lett 82: 211–216

    PubMed  CAS  Google Scholar 

  • Hamet P, Tremblay J, Pang SC, Garcia R, Thibault G, Gutkowska J, Cantin M, Genest J (1984) Effect of native and synthetic atrial natriuretic factor on cyclic GMP. Biochem Biophys Res Commun 123: 515–527

    PubMed  CAS  Google Scholar 

  • Hanley MR (1985) Neuropeptides as mitogens. Nature 315: 14–15

    PubMed  CAS  Google Scholar 

  • Hassall CJS, Burnstock G (1986) Intrinsic neurons and associated cells of the guineapig heart in culture. Brain Res 364: 102–113

    PubMed  CAS  Google Scholar 

  • Hescheler J, Rosenthal W, Hinsch K–D, Wulfern M, Trautwein W, Schultz G (1988) Angiotensin II–induced stimulation of voltage–dependent Ca2+ currents in an adrenal cortical cell line. EMBO J 7: 619–624

    PubMed  CAS  Google Scholar 

  • Hickey KA, Rubany G, Paul RJ, Highsmith RF (1985) Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am J Physiol 248: C550–C556

    PubMed  CAS  Google Scholar 

  • Hirata Y, Tomita M, Takada S, Yoshimi H (1985) Vascular receptor binding activities and cyclic GMP responses by synthetic human and rat atrial natriuretic peptides ( ANF) and receptor down-regulation by ANP. Biochem Biophys Res Commun 128: 538–546

    Google Scholar 

  • Hirata Y, Yoshimi H, Takata S, Watanabe TX, Kumagai S, Nakajima K, Sakakibara S (1988) Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells. Biochem Biophys Res Commun 154: 868–875

    PubMed  CAS  Google Scholar 

  • Hiwatari M, Satoh K, Angus JA, Johnston CI (1986) No effect of atrial natriuretic factor on cardiac rate, force and transmitter release. Clin Exp Pharmacol Physiol 13: 163–168

    PubMed  CAS  Google Scholar 

  • Hokfelt T, Johansson O, Ljungdahl A, Lundberg JM, Schultzberg M (1980) Peptidergic neurones. Nature 284: 515–521

    PubMed  CAS  Google Scholar 

  • Hokfelt T, Lundberg JM, Lagercrantz H, Tatemoto K, Mutt V, Lundberg JM, Terenius L, Everitt BJ, Fuxe K, Agnati LF, Goldstein M (1983) Occurrence of neuropeptide Y ( NPY)-like immunoreactivity in catecholamine neurons in the human medulla oblongata. Neurosci Lett 36: 217–222

    Google Scholar 

  • Hokfelt T, Johansson O, Goldstein M (1984) Chemical anatomy of the brain. Science 225: 1326–1334

    PubMed  CAS  Google Scholar 

  • Holden WE, McCall E (1984) Hypoxia-induced contractions of porcine pulmonary artery strips depend on intact endothelium. Exp Lung Res 7: 101–112

    PubMed  CAS  Google Scholar 

  • Hu JR, Berninger UG, Lang RE (1988a) Endothelin stimulates atrial natriuretic peptide ( ANP) release from rat atria. Eur J Pharmacol 158: 177–178

    Google Scholar 

  • Hu JR, von Harsdorf R, Lang RE (1988b) Endothelin has potent inotropic effects in rat atria. Eur J Pharmacol 158: 275–278

    PubMed  CAS  Google Scholar 

  • Huang CL, Lewicki J, Johnson LK, Cogan MG (1985) Renal mechanism of action of rat atrial natriuretic factor. J Clin Invest 75: 769–773

    PubMed  CAS  Google Scholar 

  • Illes P, Pfeiffer N, Kugelgen IV, Starke K (1985) Presynaptic opioid receptor subtypes in the rabbit ear artery. J Pharmacol Exp Ther 232: 526–533

    PubMed  CAS  Google Scholar 

  • Imada T, Takayanagi R, Inagami T (1985) Changes in the content of atrial natriuretic factor with the progression of hypertension in spontaneously hypertensive rats. Biochem Biophys Res Commun 133: 759–765

    PubMed  CAS  Google Scholar 

  • Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T (1988) Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria. Am J Physiol 255: H970–H973

    PubMed  CAS  Google Scholar 

  • Itoh Y, Yanagisawa M, Ohkubo S, Kimura C, Kosaka T, Inoue A, Ishida N, Mitsui Y, Onda H, Fujimo M, Masaki T (1988) Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. FEBS Lett 231: 440–444

    PubMed  CAS  Google Scholar 

  • Joint Nomenclature and Standardization Committee of the International Society of Hypertension American Heart Association and the World Health Organization (1987) J Hypertens 5

    Google Scholar 

  • Ju G, Hökfelt T, Brodin E, Fahrenkrug J, Fischer JA, Frey P, Eide RP, Brown JC (1987) Primary sensory neuron of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide-and cholecystokinin-immunoreactive ganglion cells. Cell Tissue Res 247: 417–431

    PubMed  CAS  Google Scholar 

  • Kai H, Kanaide H, Nakamura M (1989) Endothelin-sensitive intracellular Ca2+ store overlaps with caffeine-sensitive one in rat aortic smooth muscle cells in primary culture. Biochem Biophys Res Commun 158: 235–243

    PubMed  CAS  Google Scholar 

  • Kangawa K, Fukuda A, Kubota I, Hayashi Y, Matsue H (1984) Identification in rat atrial tissue of multiple forms of natriuretic polypeptides of about 3000 daltons. Biochem Biophys Res Commun 121: 585–591

    PubMed  CAS  Google Scholar 

  • Kasakov L, Ellis J, Kirkpatrick K, Milner P, Burnstock G (1988) Direct evidence for concomitant release of noradrenaline, adenosine 5’-triphosphate and neuropeptide Y from sympathetic nerve supplying the guinea-pig vas deferens. J Auton Nerv Syst 22: 75–82

    PubMed  CAS  Google Scholar 

  • Katsube N, Wakitani K, Fok FK, Tjoeng FS, Zupec ME, Eubanks SR, Adams SP, Needleman P (1985) Differential structure-activity relationships of atrial peptides as natriuretics and renal vasodilators in the dog. Biochem Biophys Res Commun 128: 325–330

    PubMed  CAS  Google Scholar 

  • Kleinert HD, Volpe M, Odell G, Marion D, Atlas SA, Camargo MJ, Laragh JH, Maack T (1986) Cardiovascular effects of atrial natriuretic factor in anesthetized and conscious dogs. Hypertension 8: 312–316

    PubMed  CAS  Google Scholar 

  • Kubota M, Mosely JM, Butera L, Dusting GJ, MacDonald PS, Martin TJ (1985) Calcitonin gene–related peptide stimulates cyclic AMP formation in rat aortic muscle cells. Biochem Biophys Res Commun 132: 88–94

    PubMed  CAS  Google Scholar 

  • Kudo T, Baird A (1984) Inhibition of aldosterone production in the adrenal glomerulosa by atrial natriuretic factor. Nature 312: 756–757

    PubMed  CAS  Google Scholar 

  • Kurtz A, Bruna RD, Pfeilschifter J, Tangner R, Bauer C (1986) Atrial natriuretic peptide inhibits renin release from juxtaglomerular cells by a cGMP–mediated process. Proc Natl Acad Sei USA 83: 4769–4773

    CAS  Google Scholar 

  • Lang RE, Thölken H, Ganten D, Luft FC, Ruskoaho H, Unger T (1985) Atrial natriuretic factor—a circulating hormone stimulated by volume loading. Nature 314: 264–266

    PubMed  CAS  Google Scholar 

  • Lappe RW, Smits JFM, Todt JA, Debets JJM, Wendt RL (1985a) Failure of atriopeptin II cause arterial vasodilation in the conscious rat. Circ Res 56: 606–612

    PubMed  CAS  Google Scholar 

  • Lappe RW, Todt JA, Wendt RL (1985b) Mechanisms of action of vasoconstrictor responses to atriopeptin II in conscious SHR. Am J Physiol 249: R781–R786

    PubMed  CAS  Google Scholar 

  • Lappe RW, Todt JA, Wendt RL (1987) Regional vasodilator actions of calcitonin generelated peptide in conscious SHR. Peptidess 8: 747–749

    CAS  Google Scholar 

  • Larose P, Meloche S, de Suich P, De Lean A, Ong H (1985) Radio–immunoassay of atrial natriuretic factor: human plasma levels. Biochem Biophys Res Commun 130: 553–558

    PubMed  CAS  Google Scholar 

  • Lattion AL, Michel JB, Arnauld E, Corrol P, Soubrier F (1986) Myocardial recruitment during ANF mRNA increase in response to volume overload in the rat. Am J Physiol 251: H890–H896

    PubMed  CAS  Google Scholar 

  • Ledsome JR, Wilson N, Courneya CA, Rankin AJ (1985) Release of atrial natriuretic peptide by atrial distension. Can J Physiol Pharmacol 63: 739–742

    PubMed  CAS  Google Scholar 

  • Lee CY, Takasaki C, Yanagisawa M, Kimura S, Goto K, Masaki T (1988) Similarity of endothelin to snake venom toxin. Nature 335: 303

    CAS  Google Scholar 

  • Leiter AB, Keutmann HT, Goodman RH (1984) Structure of a precursor to human pancreatic polypeptide. J Biol Chem 259: 14702–14705

    PubMed  CAS  Google Scholar 

  • Leitman DC, Murad F (1986) Comparison of binding and cyclic GMP accumulation by atrial natriuretic peptides in endothelial cells. Biochem Biophys Res Commun 885: 74–79

    CAS  Google Scholar 

  • Leitman DC, Andresen JW, Catalano RM, Waldman SA, Tuan JJ, Murad F (1988) Atrial natriuretic peptide binding, crosslinking, and stimulation of cyclic GMP accumulation and particulate guanylate cyclase activity in cultured cells. J Biol Chem 263: 3720–3728

    PubMed  CAS  Google Scholar 

  • Lenz HJ, Rivier JE, Brown MR (1985) Biological actions of human and rat calcitonin gene-related peptide. Regul Pept 12: 81–89

    PubMed  CAS  Google Scholar 

  • Lewicki JA, Greenberg B, Yamanaka M, Vlasuk G, Brewer M, Gardner D, Baxter J, Johnson LK, Fiddess JC (1986) Cloning, sequence analysis, and processing of the rat and human atrial natriuretic peptide precursors. Fed Proc 45: 2086–2090

    PubMed  CAS  Google Scholar 

  • Leys K, Schachter M, Sever P (1987) Autoradiographic localisation of NPY receptors in rabbit kidney: comparison with rat, guinea–pig and human. Eur J Pharmacol 134: 233–237

    PubMed  CAS  Google Scholar 

  • Lundberg JM, Hókfelt T (1983) Coexistence of peptides and classical transmitters. Trendo Neurol Sci 6: 325–333

    CAS  Google Scholar 

  • Lundberg JM, Stjárne L (1984) Neuropeptide Y (NPY) depresses the secretion of 3Hnoradrenaline and the contractile response evoked by field stimulation, in the rat vas deferens. Acta Physiol Scand 120: 477–479

    PubMed  CAS  Google Scholar 

  • Lundberg JM, Tatemoto K (1982) Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to a-adrenoceptor-resistant sympathetic vasoconstriction. Acta Physiol Scand 116: 393–402

    Google Scholar 

  • Lundberg JM, Terenius L, Hókfelt T, Martling C-R, Tatemoto K, Mutt V, Polak JM, Bloom SR (1982) Neuropeptide Y ( NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand 116: 477–480

    Google Scholar 

  • Lundberg JM, Hua XY, Franco-Cereceda A (1984a) Effects of neuropeptide Y ( NPY) on mechanical activity and neurotransmission in the heart, vas deferens and urinary bladder of the guinea–pig. Acta Physiol Scand 121: 325–332

    Google Scholar 

  • Lundberg JM, Terenius L, Hókfelt T, Tatemoto K (1984b) Comparative immunohistochemical and biochemical analysis of pancreatic polypeptide-like peptides with special reference to presence of neuropeptide Y in central and peripheral neurons. J Neurosci 4: 2376–2386

    PubMed  CAS  Google Scholar 

  • Lundberg JM, Franco-Cereceda A, Hua X, Hókfelt T, Fischer JA (1985a) Co-existence of substance P and calcitonin gene-related peptide immunoreactivities in sensory nerves in relation to cardiovascular bornchoconstrictor effects of capsaicin. Eur J Pharmacol 108: 315–322

    PubMed  CAS  Google Scholar 

  • Lundberg JM, Saria A, Franco-Cereceda A, Hókfelt T, Terenius L, Goldtein M (1985b) Differential effects of reserpine and 6-hydroxydopamine on neuropeptide Y ( NPY) and noradrenaline in peripheral neurons. Naunyn–Schmiedeberg’s Arch Pharmacol 328: 386–401

    Google Scholar 

  • Lundberg JM, Torssell L, Sollevi A, Theodorsson-Norheim E, Pernow J, Anggard A,

    Google Scholar 

  • Hamberger B (1985c) Neuropeptide Y and sympathetic vascular control in man. Regul Pept 13: 41–52

    PubMed  Google Scholar 

  • Lundberg JM, Rudehill JM, Sollevi A, Theodorsson-Norheim E, Hamberger B (1986) Frequency- and reserpine-dependent chemical coding of sympathetic transmission: differential release of noradrenaline and neuropeptide Y from pig spleen. Neurosci Lett 36: 96–100

    Google Scholar 

  • Lundberg JM, Hemsen A, Larsson O, Rudehill A, Saria A, Fredholm BB (1988) Neuropeptide Y receptor in pig spleen: binding characteristics, reduction of cyclic AMP formation and calcium antagonist inhibition of vasoconstriction. Eur J Pharmacol 145: 21–29

    PubMed  CAS  Google Scholar 

  • Maack T (1985) Atrial natriuretic factor: structure and functional properties. Kidney Int 27: 607–615

    PubMed  CAS  Google Scholar 

  • Maack T, Marion DN, Camargo MJF, Kleinert HD, Laragh JH, Vaughan ED Jr, Atlas SA (1984) Effect of auriculin (atrial natriuretic factor) on blood pressure, renal function and the renin-aldosterone system in dogs. Am J Med 77: 1069–1075

    PubMed  CAS  Google Scholar 

  • Maack T, Suzuki M, Almeida FA et al. (1987) Physiological role of silent receptors of atrial natriuretic factor. Science 238: 675–677

    PubMed  CAS  Google Scholar 

  • Maki M, Takayanagi R, Misono KS, Pandey KN, Tibbetts C, Inagami T (1984) Structure of rat atrial natriuretic factor precursor deduced from cDNA sequences. Nature 309: 722–724

    PubMed  CAS  Google Scholar 

  • Marsden PA, Danthuluri NR, Brenner BM, Ballermann BJ, Brock TA (1989) Endothelin action on vascular smooth muscle involves inositol triphosphate and calcium mobilization. Biochem Biophys Res Commun 158: 86–93

    PubMed  CAS  Google Scholar 

  • Marsh EA, Seymour AA, Haley AB, Whinney MA, Napier MA, Nutt RF, Blaine EH (1985) Renal blood pressure responses to synthetical atrial natriuretic factor in spontaneously hypertensive rats. Hypertension 7: 386–391

    PubMed  CAS  Google Scholar 

  • McEwan J, Larkin S, Davies G, Chierchia S, Brown M, Stevenson J, Maclntyre I, Maseri A (1986) Calcitonin gene-related peptide: a potent dilator of human epicardial coronary arteries. Circulation 74: 1243–1247

    PubMed  CAS  Google Scholar 

  • Minth CD, Andrews PC, Dixon JE (1986) Characterization, sequence, and expression of the cloned human neuropeptide Y gene. J Biol Chem 261: 11974–11979

    PubMed  CAS  Google Scholar 

  • Moncada S, Glryglewski R, Bunting S, Vane JR (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxidase to an unstable substance that inhibits platelet aggregation. Nature 263: 663–665

    PubMed  CAS  Google Scholar 

  • Morii N, Nakao K, Kihara M, Sugawara A, Skamoto M, Yamori Y, Imura H (1986) Decreased content in left atrium and increased plasma concentration of atrial natriuretic polypeptide in spontaneously hypertensive rats ( SHR) and SHR strokeprone. Biochem Biophys Res Commun 135: 74–81

    Google Scholar 

  • Mulderry PK, Ghatei MA, Rodrigo J, Allen JM, Rosenfeld MG, Polak JM, Bloom SR (1985) Calcitonin gene–related peptide in cardiovascular tissue of the rat. Neuroscience 14: 947–954

    PubMed  CAS  Google Scholar 

  • Miiller FB, Erne P, Raine AEG, Bolli P, Linder L, Resink TJ, Cottier C, Buhler FR (1986) Atrial antipressor natriuretic peptide: release mechanisms and vascular action in man. J Hypertens 4. S109–S114

    Google Scholar 

  • Murray RD, Itoh S, Inagami T, Misono K, Seto S, Scicli AG, Carretero OA (1985) Effects of synthetic atrial natriuretic factor in the isolated perfused rat kidney. Am J Physiol 249: F603–F609

    PubMed  CAS  Google Scholar 

  • Napier MA, Vandlen RL, Albers-Schoberg G, Nutt RF, Brady S, Lyle T, Winquist R, Faison EP, Heinel LA, Blaine EH (1984) Specific membrane receptors for atrial natriuretic factor in renal and vascular tissues. Proc Natl Acad Sci USA 81: 5946–5950

    PubMed  CAS  Google Scholar 

  • Nemer M, Chamberland M, Sirois D, Argentin S, Drouin J, Dixon RAF, Zivin RA, Condra JH (1984) Gene structure of the human cardiac hormone precursor, pronatriodilatin. Nature 312: 654–656

    PubMed  CAS  Google Scholar 

  • O’Brien RF, Robbins RJ, McMurty IF (1987) Endothelial cells in culture produce a vasoconstrictor substance. J Cell Physiol 132: 263–270

    PubMed  Google Scholar 

  • Oikawa S, Imai M, Veno A, Tanaka S, Nogushi T, Nkazato H, Kangawa K, Fukuda A, Matsuo H (1984) Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic polypeptide. Nature 309: 724–726

    PubMed  CAS  Google Scholar 

  • Opgenorth TJ, Burnett JC Jr, Granger JP, Scriven TA (1986) Effects of atrial natriuretic peptide on renin secretion in nonfiltering kidney. Am J Physiol 250: F798–F801

    PubMed  CAS  Google Scholar 

  • Osol G, Halpern W, Tesfamarian B, Nakayama K, Weinberg D (1986) Synthetic atrial natriuretic factor does not dilate resistance-sized arteries. Hypertension 8: 606–610

    PubMed  CAS  Google Scholar 

  • Palmer RMJ, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524–526

    PubMed  CAS  Google Scholar 

  • Perlman MO, Perlman JM, Adamo ML, Hazelwood RL, Dyckes DF (1987) Binding of C-terminal segments of neuropeptide Y to chicken brain. Int J Pept Protein Res 30: 153–162

    PubMed  CAS  Google Scholar 

  • Pernow J, Saria A, Lundberg JM (1986) Mechanisms underlying pre- and postjunctional effects of neuropeptide Y in sympathetic vascular control. Acta Physiol Scand 126: 239–249

    PubMed  CAS  Google Scholar 

  • Pernow J, Öhlen A, Hökfelt T, Nilsson O, Lundberg JM (1987a) Neuropeptide Y: presence in perivascular noradrenergic neurons and vasoconstrictor effects on skeletal muscle blood vessels in experimental animals and man. Regul Pept 19: 313–324

    PubMed  CAS  Google Scholar 

  • Pernow J, Svenberg T, Lundberg JM (1987b) Actions of calcium antagonists on pre- and postjunctional effects of neuropeptide Y on human peripheral blood vessels in vitro. Eur J Pharmacol 136: 207–218

    PubMed  CAS  Google Scholar 

  • Polak JM, Bloom SR (1984) Regulatory peptides the distribution of two newly discovered peptides: PHI and NPY Peptides: 5 (Suppl) 79–89

    CAS  Google Scholar 

  • Potter E (1987) Presynaptic inhibition of cardiac vagal postganglionic nerves by neuropeptide Y. Neurosci Lett 83: 101–106

    PubMed  CAS  Google Scholar 

  • Rapaport RM, Dmeznim MB, Murad F (1983) Endothelium–dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 306: 174–176

    Google Scholar 

  • Reinecke M (1987) Untersuchungen zur peptidergen Innervation des Herzens. Verb Anat Ges 81: 115–127

    Google Scholar 

  • Resink TJ, Scott-Burden T, Bühler FR (1988) Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells. Biochem Biophys Res Commun 157: 1360–1368

    PubMed  CAS  Google Scholar 

  • Resink TJ, Scott-Burden T, Bühler FR (1989) Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells. Biochem Biophys Res Commun 158: 279–286

    PubMed  CAS  Google Scholar 

  • Reynolds EE, Shinji Y (1988) Neuropeptide Y receptor-effector coupling mechanisms in cultured vascular smooth muscle cells. Biochem Biophys Res Commun 151: 919–925

    PubMed  CAS  Google Scholar 

  • Richards AM, Nicholls MG, Ikram H, Webster MW, Yandle TG, Espiner EA (1985a) Renal, hemodynamic and hormonal effects of human a atrial natriuretic peptide in healthy volunteers. Lancet 1: 545–548

    PubMed  CAS  Google Scholar 

  • Richards AM, Nicholls MG, Espiner EA, Ikram H, Yandle TG, Joyce SL, Cullens MM (1985b) Effects of a-human atrial natriuretic peptide in essential hypertension. Hypertension 7: 812–817

    PubMed  CAS  Google Scholar 

  • Richardt G, Haass M, Neeb S, Hock M, Lang RE, Schömig A (1988) Nicotine–induced release of noradrenaline and neuropeptide Y in guinea-pig heart. Klin Wochenschr 66: 21–27

    PubMed  CAS  Google Scholar 

  • Rioux F, Bachelard H, Martel J-C, St-Pierre S (1986) The vasoconstrictor effect of neuropeptide Y and related peptides in the guinea-pig isolated heart. Peptides 7: 27–31

    PubMed  CAS  Google Scholar 

  • Rosenfeld MG, Mermod JJ, Amava SG, Swanon LW, Sawchenko PE, Rivier J, Vale WW, Evans RM (1983) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304: 240

    Google Scholar 

  • Rubany GM, Vanhoutte PM (1985) Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium. J Physiol (Lond) 34: 45–56

    Google Scholar 

  • Saito Y, Nakao K, Arai H et al. (1987) Atrial natriuretic polypetide ( ANP) in human ventricle increased gene expression of ANP in dilated cardiomyopathy. Biochem Biophys Res Commun 148: 211–217

    Google Scholar 

  • Saria A, Theodorsson–Norheim E, Lundberg JM (1984) Evidence for specific neuropeptide Y-binding sites in rat brain synaptosomes. Eur J Pharmacol 107: 105–107

    CAS  Google Scholar 

  • Sasaki A, Kida O, Kangawa K, Matsuo H, Tanaka K (1985) Hemodynamic effects of a-human atrial natriuretic polypeptide (a–hANP) in rats. Eur J Pharmacol 109: 405–407

    PubMed  CAS  Google Scholar 

  • Schelling P, Ganten D, Speck G, Fischer H (1979) Effects of angiotensin II and antagonist saralasin on cell growth and ienin in 3T3 and SV3T3 cells. J Cell Physiol 98 (3): 503–513

    PubMed  CAS  Google Scholar 

  • Schenk DB, Johnson LK, Schwartz K, Sista H, Scarborough RM, Lewicki JA (1985a) Distinct atrial natriuretic factor receptor sites on cultured bovine aortic smooth muscle and endothelial cells. Biochem Biophys Res Commun 127: 433–442

    PubMed  CAS  Google Scholar 

  • Schenk DB, Phelps MN, Porter JG, Scarborough RM, McEnroe GA, Lewicki JA (1985b) Identification of the receptor for atrial natriuretic factor on cultured vascular cells. J Biol Chem 260: 14887–14890

    PubMed  CAS  Google Scholar 

  • Schiffrin EL, Chartier L, Thibault G, St Louis J, Cantin M, Genest J (1985) Vascular and adrenal receptors for atrial natriuretic factor in the rat. Circ Res 56: 801–807

    PubMed  CAS  Google Scholar 

  • Schiller PW, Maziak L, Nguyen TMD, Godin J, Garcia R, De Leadn A, Cantin M (1985)

    Google Scholar 

  • Synthesis and biological activity of a linear fragment of the atrial natriuretic factor (ANF). Biochem Biophys Res Commun 131:1056–1062

    Google Scholar 

  • Schwartz D, Geller DM, Manning PT, Siegel NR, Fok KF, Smith CE, Needleman P (1985) Ser-leu-arg-arg-atriopeptin III: the major circulating form of atrial peptide. Science 229: 397–400

    PubMed  CAS  Google Scholar 

  • Seidman CE, Duby AD, Choi E, Graham RM, Haber E, Homey C, Smith JA, Seidman JG (1984) The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science 225: 324–326

    PubMed  CAS  Google Scholar 

  • Siggins GR, Gruol DL (1986) Mechanisms of transmitter action in the vertebrate central nervous system. In: Mountcastle VB, Bloom FE, Geiger SR (eds) The nervous system. Intrinsic regulatory systems of the brain. Am Physiol Soc, Bethesda, p 1 (Handbook of physiology, vol 4 )

    Google Scholar 

  • Sigrist S, Franco-Cereceda A, Muff R, Henke H, Lundberg JM, Fischer JA (1986) Specific receptor and cardiovascular effects of calcitonin gene-related peptide. Endocrinology 119: 381–389

    PubMed  CAS  Google Scholar 

  • Skofitsch G, Jacobowitz DM (1985) Quantitative distribution of calcitonin gene–related peptide in the rat central nervous system. Peptides 6: 1069–1073

    PubMed  CAS  Google Scholar 

  • Snajder RM, Rapp JP (1986) Elevated atrial natriuretic polypeptide in plasma of hypertensive Dahl salt-sensitive rats. Biochem Biophys Res Commun 137: 876–883

    Google Scholar 

  • Snyder SH (1980) Brain peptides as neurotransmitters. Science 209: 976–981

    PubMed  CAS  Google Scholar 

  • Sonnenberg H, Cupples WA, de Bold AJ, Veress AT (1982) Intrarenal localization of the natriuretic effect of cardiac atrial extract. Can J Physiol Pharmacol 60: 1149–1152

    CAS  Google Scholar 

  • Sonnenberg H, Honrath U, Chuong CK, Wilson DR (1986) Atrial natriuretic factor inhibits sodium transport in medullary collecting duct. Am J Physiol 250: F936–F966

    Google Scholar 

  • Sternini C, Brecha N (1985) Distribution and colocalization of neuropeptide Y- and tyrosine hydroxylase–like immunoreactivity in the guinea-pig heart. Cell Tissue Res 241: 93–102

    PubMed  CAS  Google Scholar 

  • Stjärne L, Lundberg JM, Astrand P (1986) Neuropeptide Y—a cotransmitter with noradrenaline and adenosine 5’-triphosphate in the sympathetic nerves of mouse vas deferens? A biochemical, physiological and electropharmacological study. Neuroscience 18: 151–166

    PubMed  Google Scholar 

  • Struthers AD, Brown MJ, Beacham JL, Morris HR, Maclntyre I, Stevenson JC (1985) The acute effect of human calcitonin generelated peptide in man. J Endocrinol 104: 129–136

    Google Scholar 

  • Studier JM, Reibaud M, Herve D, Blanc G, Glowinski J, Tassin JP (1986) Opposite effects of sulfated cholecystokinin in DA-sensitive adenylate cyclase in two areas of the rat nucleus accumbens. Eur J Pharmacol 126: 125–128

    Google Scholar 

  • Sugiura M, Inagami T, Hare GMT, Johns JA (1989) Endothelin action: inhibition by a protein kinase C inhibitor and involvement of phosphoinositols. Biochem Biophys Res Commun 158: 170–176

    PubMed  CAS  Google Scholar 

  • Takagi M, Matsuoka H, Atarashi K, Yagi S (1988) Endothelin: a new inhibitor of renin release. Biochem Biophys Res Commun 157: 1164–1168

    PubMed  CAS  Google Scholar 

  • Tatemoto K (1982) Neuropeptide Y: complete amino acid sequence of the brain peptide Proc Natl Acad Sei USA 79: 5485–5491

    CAS  Google Scholar 

  • Thibault G, Lazure C, Schiffrin EL, Gutkowska J, Chartier L, Garcia R, Seidah NG, Chretien M, Genest J, Cantin M (1985) Identification of a biologically active circulating form of rat atrial natriuretic factor. Biochem Biophys Res Commun 130: 981–986

    PubMed  CAS  Google Scholar 

  • Thorn SM, Hughes AD, Goldberg P, Martin G, Schachter M, Sever PS (1987) The actions of calcitonin gene–related peptide and vasoactive intestinal peptide as vasodilators in man in vivo and in vitro. Br J Clin Pharmacol 24: 139–144

    Google Scholar 

  • Tomobe Y, Miyauchi T, Saito A, Yanagisawa M, Kimura S, Goto K, Masaki T (1988) Effects of endothelin on the renal artery from spontaneously hypertensive and Wistar Kyoto rats. Eur J Pharmacol 152: 373–374

    PubMed  CAS  Google Scholar 

  • Uddman R, Edvinsson L, Ekblad E, Hakanson R, Sundler F (1986) Calcitonin generelated peptide (CGRP): perivascular distribution and vasodilator effects. Regul Pept 15: 1–23

    PubMed  CAS  Google Scholar 

  • Undén A, Bartfai T (1984) Regulation of neuropeptide Y ( NPY) binding by guanine nucleotides in the rat cerebral cortex. FEBS Lett 177: 125–128

    Google Scholar 

  • Vallejo M, Lightman SL (1986) Pressor effect of centrally administered neuropeptide Y in rats: role of sympathetic nervous system and vasopressin. Life Sei 38: 1859–1866

    CAS  Google Scholar 

  • Van Renterghem C, Vigne P, Brahanin J, Schmid-Alliana A, Freiin C, Lazdunski M (1988) Molecular mechanism of action of the novel vasoconstrictor peptide endothelin Biochem Biophys Res Commun 157: 977–985

    Google Scholar 

  • Varndell NM, Polak JM, Allen JM, Terenghi G, Bloom SR (1984) Neuropeptide tyrosine ( NPY) immunoreactivity in norepinephrine-containing cells and nerves of the mammalian adrenal gland. Endocrinology 114: 1460–1462

    Google Scholar 

  • Villarreal D, Freeman RH, Davis JO, Verbürg KM, Vari RC (1986) Renal mechanisms for suppression of renin secretion by atrial natriuretic factor. Hypertension 8: II28–II35

    Google Scholar 

  • Volpe M, Odell G, Kleinert HD, Camargo MJF, Laragh JH, Maack T, Vaughan ED Jr, Atlas SA (1985) Effects of atrial natriuretic factor on blood pressure, renin and aldosterone in renovascular hypertensive rats. Hypertension 7: 143–148

    Google Scholar 

  • Volpe M, Sosa RE, Müller FB, Camargo MJF, Glorioso N, Laragh JH, Maack T, Atlas SA (1986) Differing hemodynamic response to atrial natriuretic factor in two models of hypertension. Am J Physiol 250: H871–H878

    PubMed  CAS  Google Scholar 

  • Wahlestedt C, Hakanson R (1986) Effects of neuropeptide Y ( NPY) at the sympathetic neuroeffector junction. Can pre- and postjunctional receptors be distinguished? Med Biol 64: 85–88

    Google Scholar 

  • Wahlestedt C, Wohlfart B, Hakanson R (1987) Effects of neuropeptide Y ( NPY) on isolated guinea–pig heart. Acta Physiol Scand 129: 459–463

    Google Scholar 

  • Wakitani K, Osshima T, Loewy AD, Holmberg SW, Cole BR, Adams SP, Fok KF, Currie MG, Needleman P (1985) Comparative vascular pharmacology of the atriopeptins. Circ Res 56: 621–627

    PubMed  CAS  Google Scholar 

  • Waldman SA, Rapaport RM, Murad R (1984) Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissue. J Biol Chem 259: 14332–14334

    PubMed  CAS  Google Scholar 

  • Weidmann P, Gnädinger MP, Ziswiler HR, Shaw S, Bachmann C, Rascher W, Uehlinger DE, Hasler L, Reubi FC (1986a) Cardiovascular, endocrine and renal effects of atrial natriuretic peptide in essential hypertension. J Hypertens 4. S71–S83

    CAS  Google Scholar 

  • Weidmann P, Hasler L, Gnädinger MP, Lang RE, Uehlinger DE, Shaw S, Rascher W, Reubi FC (1986b) Blood levels and renal effects of atrial natriuretic peptide in normal man. J Clin Invest 77: 734–742

    PubMed  CAS  Google Scholar 

  • Weidmann P, Hellmüller B, Uehlinger DE, Lang RE, Gnädinger MP, Hasler L, Shaw S, Bachmann C (1986c) Plasma levels and cardiovascular, endocrine, and excretory effects of atrial natriuretic peptide during different sodium intakes in man. J Clin Endocrinol Metab 62: 1027–1036

    PubMed  CAS  Google Scholar 

  • Westfall TC, Carpentier S, Chen X, Beinfeld MC, Naes L, Meldrum MJ (1987) Prejunctional and postjunctional effects of neuropeptide Y at the noradrenergic neuroeffector junction of the perfused mesenteric arterial bed of the rat. J Cardiovasc Pharmacol 10: 716–722

    PubMed  CAS  Google Scholar 

  • Westlind–Danielsson A, Unden A, Abens J, Andell S, Bartfai T (1987) Neuropeptide Y receptors and the inhibition of adenylate cyclase in the human frontal and temporal cortex. Neurosci Lett 74: 237–242

    Google Scholar 

  • Winquist RJ, Faison EP, Nutt RF (1984a) Vasodilator profile of synthetic atrial natriuretic factor. Eur J Pharmacol 102: 169–173

    PubMed  CAS  Google Scholar 

  • Winquist RJ, Faison EP, Waldman SA, Schwartz K, Murad F, Rapaport RM (1984b) Atrial natriuretic factor elicits an endothelium–independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proc Natl Acad Sci USA 81: 7661–7664

    PubMed  CAS  Google Scholar 

  • Wright CE, Fozard JR (1988) Regional vasodilation is a prominent feature of the haemodynamic response to endothelin in anaesthetized, spontaneously hypertensive rats. Eur J Pharmacol 155: 201–203

    PubMed  CAS  Google Scholar 

  • Yamaji T, Ishibashi M, Takaku F (1985) Atrial natriuretic factor in human blood. J Clin Invest 76: 1705–1709

    PubMed  CAS  Google Scholar 

  • Yamanaka M, Greenberg B, Johnson L, Seilhamer J, Brewer M, Friedemann T, Miller J, Atlas S, Laragh J, Lewicki J, Fiddes J (1984) Cloning and sequence analysis of cDNA for the rat atrial natriuretic factor precursor. Nature 309: 719–722

    PubMed  Google Scholar 

  • Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayajhi M, Mitsci Y, Yazaki Y, Soto K, Masaki T (1988a) A movel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411–415

    PubMed  CAS  Google Scholar 

  • Yanagisawa M, Inoue A, Ishikawa T, Kasuya Y, Kimura S, Kumagaye S-I, Nakjima K, Watanabe TX, Sakakibara S, Goto K, Masaki T (1988b) Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc Natl Acad Sci USA 85: 6964–6967

    PubMed  CAS  Google Scholar 

  • Yasujima M, Abe K, Konzuki M, Tanno M, Kasai Y, Sato M, Omata K, Kudo K, Tsunoda K, Takeuchi K, Yoshinaga K, Inagami T (1985) Atrial natriuretic factor inhibits the hypertension induced by chronic infusion of norepinephrine in conscious rats. Circ Res 57: 470–474

    PubMed  CAS  Google Scholar 

  • Yukimura TK, Ito K, Takenaga T, Yamamoto K, Kangawa K, Matsuo H (1984) Renal effects of synthetic human atrial natriuretic polyepitde in anesthetized dogs. Eur J Pharmacol 103: 363–366

    PubMed  CAS  Google Scholar 

  • Zaidi M, Bevis PJ, Girgis SF, Lynch C, Stevenson JC, Maclntyre I (1985) Circulating CGRP comes from the perivascular nerves. Eur J Pharmacol 11: 283–284

    Google Scholar 

  • Zeidel ML, Seifter JL, Lear S, Brenner BM, Silva P (1986) Atrial peptides inhibit oxygen consumption in kidney medullary collecting duct cells. Am J Physiol 251: F379–F383

    PubMed  CAS  Google Scholar 

  • Zukowska-Grojec Z, Marks ES, Haass M (1987) Neuropeptide Y is a potent vasoconstrictor and a cardiodepressant in rat. Am J Physiol 253: H1234–H1239

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. R. E. Lang
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. German Institute for High Blood Pressure Research and Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg, Germany

    Detlev Ganten M.D, Ph.D.

  2. Medical College of Ohio, CS10008, 300 Arlington Avenue, Toledo, OH, 43699, USA

    Patrick J. Mulrow M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Lang, R.E. (1990). Peptides in Hypertension. In: Ganten, D., Mulrow, P.J. (eds) Pharmacology of Antihypertensive Therapeutics. Handbook of Experimental Pharmacology, vol 93 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74209-5_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74209-5_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74211-8

  • Online ISBN: 978-3-642-74209-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation