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Effects of Cigarette Smoke on Uptake of Asbestos and Iron Oxide by Rat Tracheal Explants

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Part of the book series: NATO ASI Series ((ASIH,volume 30))

Abstract

A variety of studies in man and animals have shown that cigarette smoke increases pulmonary mineral dust retention. This phenomenon has been demonstrated demonstrated both for inert dusts such as iron oxide (Cohen et al 1979; Gilks et al 1988) and toxic dusts such as asbestos (McFadden et al 1986a). Histopathologic studies in animals indicate that the effect of increased dust retention is increased penetration of dust into the walls of small airways. Again this is true for both inert and toxic dusts (McFadden et al 1986b; Gilks et al 1988).

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References

  • Begin R, Cantin A (1988): Fibrogenic activity in early radiologic silicosis. Amer Rev Respir Dis 137 (Pt2): 352.

    Google Scholar 

  • Bowden DH (1987): Macrophages, dust and pulmonary diseases. Exp Lung Res 12: 89–107.

    Article  PubMed  CAS  Google Scholar 

  • Churg A, Tron V, Wright JL (1987): Effects of cigarette smoke on retention of asbestos fibers in various morphologic compartments of the guinea pig lung. Amer J Pathol 129: 385–393.

    CAS  Google Scholar 

  • Cohen D, Arai SF, Brain JD (1979): Smoking impairs long-term clearance from the lung. Science 204: 514–516.

    Article  PubMed  CAS  Google Scholar 

  • Gilks B, Wright J, Churg A (1988): Effects of Cigarette Smoke on Tissue Uptake and Retention of Iron Oxide. Amer Rev Respir Dis 137: 1382–1384.

    CAS  Google Scholar 

  • Hammond EC, Selikoff I J, Seidman H (1979): Asbestos exposure, smoking, and death rates. Ann NY Acad Sci 330: 473–492.

    Article  PubMed  CAS  Google Scholar 

  • Haugen A, Schafer PW, Lechner JF, Stoner GD, Trump BF, Harris CC (1982): Cellular ingestion, toxic effects, and lesions observed in human bronchial epithelial tissue and cells cultured with asbestos and glass fibers. Int J Cancer 30: 265–272.

    Article  PubMed  CAS  Google Scholar 

  • Hobson J, Gilks B, Wright J, Churg A (1988): Cigarette Smoke Directly Enhances Asbestos Fiber Penetration and Asbestos-Induced Epithelial Proliferation in Rat Tracheal Explants. JNCI 80: 518–521.

    PubMed  CAS  Google Scholar 

  • Kumnar RK, Bennett RA, Brody AR (1988): A homologue of platelet-dervied growth factor produced by rat alveolar macrophages. FASEB J 2: 2272–2277.

    Google Scholar 

  • McFadden D, Wright JL, Wiggs B, Churg, A (1986a): Smoking inhibits asbestos clearance. Am Rev Respir Dis 133: 372–374.

    PubMed  CAS  Google Scholar 

  • McFadden D, Wright J, Wiggs B, Churg A (1986b): Cigarette smoke increases the penetration of asbestos fibers into airway walls. Am J Pathol 123: 95–99.

    PubMed  CAS  Google Scholar 

  • Mossman BT, Craighead JE (1979): Use of hamster tracheal organ cultures for assessing the cocarcinogenic effects of inorganic particulates on the respiratory epithelium. Prog Exp Tumor Res 24: 37–47.

    PubMed  CAS  Google Scholar 

  • Mossman BT, Eastman A, Landesman JM, Bresnick E (1983): Effects of crocidolite and chrysotile asbestos on cellular uptake and metabolism of benzo(a)pyrene in hamster tracheal epithelial cells. Environ Hlth Perspect 51: 331–335.

    Article  CAS  Google Scholar 

  • Plowman PN (1982): The pulmonary macrophage population of human smokers. Ann Occup Hyg 25: 393–405.

    Article  PubMed  CAS  Google Scholar 

  • Topping DC, Nettesheim P, Martin DH (1980): Toxic and tumorigenic effects of asbestos on tracheal mucosa. J Environ Pathol Toxicol 3: 261–275.

    PubMed  CAS  Google Scholar 

  • Weiss W (1984): Cigarette smoke, asbestos, and small irregular opacities. Am Rev Respir Dis 130: 293–301.

    PubMed  CAS  Google Scholar 

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© 1989 Springer-Verlag Berlin Heidelberg

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Churg, A., Wright, J.L. (1989). Effects of Cigarette Smoke on Uptake of Asbestos and Iron Oxide by Rat Tracheal Explants. In: Mossman, B.T., Bégin, R.O. (eds) Effects of Mineral Dusts on Cells. NATO ASI Series, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74203-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-74203-3_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74205-7

  • Online ISBN: 978-3-642-74203-3

  • eBook Packages: Springer Book Archive

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