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Regulation of Adenylate Cyclase in Mammalian Cells and Saccharomyces Cerevisiae

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Receptors, Membrane Transport and Signal Transduction

Part of the book series: NATO ASI Series ((ASIH,volume 29))

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Summary

A large number of transmembrane signalling systems transduce signals through heterotrimeric GTP binding proteins (G-proteins). In the most intensively studied system -adenylate cyclase, there are two distinct G-protein transducing systems which respond to stimulatory and inhibitory receptors respectively. The studies on the hormonally regulated adenylate cyclase have led to a detailed understanding of the molecular mechanism of signal transduction. This system therefore serves also as an archtype model for the study of other transmembrane signalling systems which possess heterotrimeric GTP binding proteins as transducer elements. One system in which the molecular mechanism of G-protein transduction is not known is the proliferation signal activated by the monomeric G-protein p21RAS. The involvement of a RAS protein as a transducer in the activation in the yeast S. cerevisiae adenylate cyclase opens new avenues towards the understanding of RAS function in mammalian cells.

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Author information

Authors and Affiliations

  1. Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem, Israel, 91904

    Alexander Levitzki

  2. Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel, 91904

    Alexander Levitzki

Authors
  1. Alexander Levitzki
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Editor information

Editors and Affiliations

  1. Biological Research Center, The National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 116 35, Athens, Greece

    A. E. Evangelopoulos

  2. Neurobiologie Moleculaire, Institut Pasteur, 28 Rue du Dr. Roux, 75724, Paris Cedex 15, France

    J. P. Changeux

  3. Membrane Bioenergetics Group, University of California, Berkeley, 2544 Life Sciences Building, 94720, Berkeley, CA, USA

    L. Packer

  4. Biological Research Center, The National Rellenic Research Foundation, 48 Vassileos Constantinou Avenue, 116 35, Athens, Greece

    T. G. Sotiroudis

  5. Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Padualaan 8, 3508 TB, Utrecht, The Netherlands

    K. W. A. Wirtz

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© 1989 Springer-Verlag Berlin Heidelberg

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Levitzki, A. (1989). Regulation of Adenylate Cyclase in Mammalian Cells and Saccharomyces Cerevisiae. In: Evangelopoulos, A.E., Changeux, J.P., Packer, L., Sotiroudis, T.G., Wirtz, K.W.A. (eds) Receptors, Membrane Transport and Signal Transduction. NATO ASI Series, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74200-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-74200-2_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74202-6

  • Online ISBN: 978-3-642-74200-2

  • eBook Packages: Springer Book Archive

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