Mechanisms of IL-3 Regulated Growth and Transformation of Hematopoietic Cells

  • James N. Ihle
  • Kazuhiro Morishita
  • Robert Isfort
  • Christopher Bartholomew
  • David Askew
  • Yacob Weinstein
Part of the NATO ASI Series book series (volume 34)

Abstract

The hematopoietic system is derived from the progeny of relatively few pluripotential stem cells which differentiate along either the lymphoid or the myeloid lineages (Joyner, 1983; Williams et al., 1984; Keller et al., 1985; Lemischka et al., 1986). Interleukin 3 (IL-3) is a T-Cell derived, 28 kd glycoprotein hematopoietic growth factor which has been shown to support the proliferation and differentiation of early hematopoietic stem cells in vitro and is speculated to have a comparable function in vivo (Weinstein et al., 1986; Ihle, 1988b). Although considerable information is available concerning the mechanisms by which IL-3 regulates the growth of hematopoietic cells, the genes and the mechanisms involved in the control of differentiation of committed hematopoietic progenitors are largely unknown.

Keywords

Zinc Lymphoma Leukemia Agarose Cysteine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • James N. Ihle
    • 1
  • Kazuhiro Morishita
    • 1
  • Robert Isfort
    • 1
  • Christopher Bartholomew
    • 1
  • David Askew
    • 1
  • Yacob Weinstein
    • 1
    • 2
  1. 1.Department of BiochemistrySt. Jude Children’s Research HospitalMemphisUSA
  2. 2.Microbiology amp; Immunology DepartmentSchool of Health Sciences, Ben Gurion University of the NegevBeer ShevaIsrael

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