Mechanisms of IL-3 Regulated Growth and Transformation of Hematopoietic Cells
The hematopoietic system is derived from the progeny of relatively few pluripotential stem cells which differentiate along either the lymphoid or the myeloid lineages (Joyner, 1983; Williams et al., 1984; Keller et al., 1985; Lemischka et al., 1986). Interleukin 3 (IL-3) is a T-Cell derived, 28 kd glycoprotein hematopoietic growth factor which has been shown to support the proliferation and differentiation of early hematopoietic stem cells in vitro and is speculated to have a comparable function in vivo (Weinstein et al., 1986; Ihle, 1988b). Although considerable information is available concerning the mechanisms by which IL-3 regulates the growth of hematopoietic cells, the genes and the mechanisms involved in the control of differentiation of committed hematopoietic progenitors are largely unknown.
KeywordsZinc Lymphoma Leukemia Agarose Cysteine
Unable to display preview. Download preview PDF.
- Beug HM, Hayman J, Graf T (1982) Myeloblasts transformed by the avian acute leukemia virus E26 are hormone-dependent for growth and for expression of a putative myb-containing protein. EMBO J 1: 1063–1073Google Scholar
- Ihle JN, Morishita K, Parker DS et al (1988a) Mechanisms in the transformation of Independent hematopoietic stem cells. In: Shen-Ong G, Potter M, Copeland N (eds) Mechanisms in myeloid tumorigenesis. Springer, New YorkGoogle Scholar
- Ihle JN (1988b) The molecular and cellular biology of interleukin-3. In: Cruse JM, Lewis Jr RE (eds) The year in immunology. Karger, New YorkGoogle Scholar
- Lee JC, Horak I, Ihle JN (1981a) Mechanisms in T-Cell leukemogenesis. II. T-Cell responses of preleukemic BALB/c mice to Moloney leukemia virus antigens. J Immunol 126: 715–722Google Scholar
- Lee JC, Ihle JN (1981b) Chronic immune Stimulation is required for Moloney leukemia virus-induced lymphomas. Nature 289:407–409Google Scholar
- Mucenski ML, Taylor BA, Copeland NG, Jenkins NA (1988a) Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors. Oncogene Res 2: 219–233Google Scholar
- Pelham HR, Brown DD (1980) A specific transcription factor that can bind either the 5S RNA gene or 5S RNA. Proc Natl Acad Sci USA 77: 4170–4174Google Scholar
- Sola B, Simon D, Mattei MG, Fichelson S, Bordereaux D, Tambourin PE, Guenet JL, Gisselbrecht S (1988) Fim-1, Fim 2/c-fms, and Fim-3, three common integration sites of Friend murine leukemia virus in myeloblasts leukemias, map to mouse chromosomes 13, 18, and 3, respectively. J Virol 62: 3973–3978PubMedGoogle Scholar