Mechanisms of IL-3 Regulated Growth and Transformation of Hematopoietic Cells
The hematopoietic system is derived from the progeny of relatively few pluripotential stem cells which differentiate along either the lymphoid or the myeloid lineages (Joyner, 1983; Williams et al., 1984; Keller et al., 1985; Lemischka et al., 1986). Interleukin 3 (IL-3) is a T-Cell derived, 28 kd glycoprotein hematopoietic growth factor which has been shown to support the proliferation and differentiation of early hematopoietic stem cells in vitro and is speculated to have a comparable function in vivo (Weinstein et al., 1986; Ihle, 1988b). Although considerable information is available concerning the mechanisms by which IL-3 regulates the growth of hematopoietic cells, the genes and the mechanisms involved in the control of differentiation of committed hematopoietic progenitors are largely unknown.
KeywordsMyeloid Lineage Hematopoietic Growth Factor Viral Integration Myeloid Cell Line Viral Integration Site
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