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Lipid Transport in Plasmodium falciparum -Infected Erythrocyte Membranes

  • Kasturi Haldar
Conference paper
Part of the NATO ASI Series book series (volume 40)

Abstract

During its intraerythrocytic development the malaria parasite induces changes in the transport of phospholipids across the host erythrocyte membrane. In the mature erythrocyte, protein mediated transport of phosphatidylethanolamine (PE) and phosphatidylserine (PS) to the cytoplasmic leaflet is an energy requiring process and appears to serve as the primary mechanism for maintaining phospholipid asymmetry at the plasma membrane (Daleke and Huestis, 1985; Tilley et. al., 1986; Zachowski et. al., 1986) Band 7 has been identified as the putative amino-phospholipid translocator in human erythrocytes (Connor and Schroit 1988). Human erythrocyte membranes do not contain a phosphatidylcholine (PC) transporter and PC transbilayer movement in these membranes is extremely slow (Op den Kamp, 1979). In erythrocytes infected with the malaria parasitesPlasmodium falciparum and Plasmodium knowlesi, there is an increased uptake and exchangeability of exogenously added radiolabeled PS, PE and PC with lipids of the host cell membrane (van der Schaft et. al., 1987; Moll et. al., 1988). However little is known about the molecular basis of these changes in parasitised erythrocytes. We have investigated the movement of fluorescent analogues of phospholipids in parasitised erythrocytes to elucidate mechanisms of lipid transport from the red cell membrane to the intracellular parasite.

Keywords

Erythrocyte Membrane Uninfected Cell Infected Erythrocyte Flip Flop Host Cell Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Kasturi Haldar
    • 1
  1. 1.Dept. Microbiology and ImmunologyStanford UniversityStanfordUSA

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