Phospholipid Localization and Mobility in Plasmodium Infected Erythrocytes

  • J. A. F. Op den Kamp
  • G. Moll
  • A. P. Simões
  • B. Roelofsen
Conference paper
Part of the NATO ASI Series book series (volume 40)

Abstract

Upon infection of erythrocytes with Plasmodium, the malaria causing parasite, the red cell membrane undergoes a variety of changes. Proteins, encoded by the parasitic DNA are inserted into the membrane (Howard 1988, Hommel and Semoff, 1988), membrane permeability is increased (Tanabe et al, 1983; Sherman, 1979) pores (Ginsburg et al, 1986) are formed, the mobility of phospholipids is increased (Taraschi et al, 1986; Beaumelle et al, 1988; Deguercy et al, 1986; van der Schaft et al, 1987; Moll et al, 1988; Haldar et al, 1989) and the ultrastractural appearance of the cell can be modified by the development of knobs on the membrane surface (Howard, 1988). Recently, a series of studies was undertaken to investigate the fate of the phospholipid complement of the host cell membrane and to establish possible, parasite induced, modifications in the composition as well as the organization of these basic membrane constituents. Here we present a short overview of the most relevant observations. Emphasis will be laid on three aspects of our work: (i) the localization of phospholipids in the membrane of the erythrocyte following infection; (ii) the transfer of phospholipids from the environment into the infected red cell, and (iii) the possible alterations in phospholipid species composition of the host erythrocyte membrane. Central to these studies are observations that parasitised erythrocytes contain, at the final stage of infection, about 6 times as much phospholipid as the non-infected cells (van der Schaft et al, 1987) and that the parasite, although equipped with a complete set of enzymes to synthesize complex phospholipids, cannot synthesize its own fatty acids (Sherman, 1979).

Keywords

Erythrocyte Membrane Infected Erythrocyte Host Cell Membrane Plasmodium Knowlesi Infected Monkey 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. A. F. Op den Kamp
    • 1
  • G. Moll
    • 1
  • A. P. Simões
    • 1
  • B. Roelofsen
    • 1
  1. 1.Centre for Biomembranes and Lipid EnzymologyState University of UtrechtUtrechtThe Netherlands

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