Protein Glycosylation: Oligosaccharyl Transferase and a Novel Recognition Protein
The amount of information about the pathway of secretory and plasma membrane glycoprotein synthesis has increased dramatically during the past decade. It is clear that not only the initial process of translation/glycosylation, but also the subsequent steps of polypeptide and oligosaccharide chain processing occur in the endomembrane system consisting of the rough endoplasmic reticulum, the Golgi complex, and vesicles derived from these subcellular organelles. Although there has been good progress in acquiring information about the overall pathway of N-linked glycoprotein synthesis in this endomembrane system, detailed characterization of the properties of the enzymes has been restricted to those involved in processing reactions in the Golgi complex. Indeed, a number of these enzymes have been isolated in pure form and some have been cloned and sequenced.
KeywordsRough Endoplasmic Reticulum Glycosylation Site Protein Disulfide Isomerase Prolyl Hydroxylase Oligosaccharide Chain
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