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Nicotinic Acetylcholine Receptors in the Nervous System pp 283–297Cite as

Regulation of Neuronal Acetylcholine Receptors by Cell-Cell Interactions

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Part of the book series: NATO ASI Series ((ASIH,volume 25))

Abstract

Much of what is known about the role of cell-cell interactions in regulating synaptic components comes from studies of the vertebrate neuromuscular junction, and by far the best understood component there is the nicotinic acetylcholine receptor (AChR). Monoclonal antibodies (mAbs) and neurotoxins are now available that recognize neuronal AChRs (for reviews see Lindstrom et al., 1987; Loring and Zigmond, 1988), and cDNA and genomic probes have been isolated for neuronal AChR mRNAs (Boulter et al., 1986, 1987; Deneris et al., 1988; Nef et al., 1988). Such probes permit comparative studies assessing whether principles governing the regulation of AChRs at the neuromuscular junction can be extended to neurotransmitter receptors at synapses on neurons. We have found that while neuronal AChRs are similar to AChRs of muscle and electric organ in a number of respects, they differ in regulation of receptor levels by presynaptic input and in regulation of receptor function by second messengers. The differences may render neuronal AChRs particularly responsive to modulation by cell-cell interactions, and the modulation could regulate neuronal detection of synaptic signalling.

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Authors and Affiliations

  1. Department of Biology, University of California, San Diego, La Jolla, California, 92093, USA

    Darwin K. Berg, R. Thomas Boyd, Stanley W. Halvorsen, Linda S. Higgins, Michele H. Jacob, Joseph F. Margiotta & Adrienne E. McEachern

  2. Worcester Foundation for Experimental Biology, Shrewsbury, MA, 01545, USA

    Michele H. Jacob

  3. Department of Pharmacology, University of California School of Medicine, San Diego, La Jolla, CA, 92093, USA

    Joseph F. Margiotta

Authors
  1. Darwin K. Berg
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  2. R. Thomas Boyd
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  3. Stanley W. Halvorsen
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  4. Linda S. Higgins
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  5. Michele H. Jacob
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  6. Joseph F. Margiotta
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  7. Adrienne E. McEachern
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Editors and Affiliations

  1. CNR Center of Cytopharmacology, Department of Medical Pharmacology, University of Milano, Via Vanvitelli 32, I-20129, Milano, Italy

    Francesco Clementi , Cecilia Gotti  & Emanuele Sher ,  & 

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© 1988 Springer-Verlag Berlin Heidelberg

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Berg, D.K. et al. (1988). Regulation of Neuronal Acetylcholine Receptors by Cell-Cell Interactions. In: Clementi, F., Gotti, C., Sher, E. (eds) Nicotinic Acetylcholine Receptors in the Nervous System. NATO ASI Series, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74167-8_21

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  • DOI: https://doi.org/10.1007/978-3-642-74167-8_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74169-2

  • Online ISBN: 978-3-642-74167-8

  • eBook Packages: Springer Book Archive

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