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The Ultrastructural Basis of Capillary Permeability

  • Conference paper
Regulatory Mechanisms of Neuron to Vessel Communication in the Brain

Part of the book series: NATO ASI Series ((ASIH,volume 33))

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Abstract

The highest level of integrative brain function requires homeostasis and isolation of the internal milieu of the brain. Homeostasis and isolation are accomplished by a constellation of brain capillary wall morphological, biochemical, and physiological mechanisms that constitute the blood-brain barrier (BBB). The ultrastructural basis of the BBB consists of tight interendothelial junctions, the absence of endothelial pores, a paucity of pinocytotic vesicles, and an increased numerical density of endothelial mitochondria. The endothelial membrane is supported by pericytes, basal lamina, and astrocytic end-foot processes.

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Author information

Authors and Affiliations

  1. The Ohio State University, Columbus, Ohio, USA

    Elizabeth M. Burns (Neurophysiologist)

  2. The University of Iowa, Iowa City, Iowa, USA

    Thomas W. Kruckeberg (Biologist)

Authors
  1. Elizabeth M. Burns
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  2. Thomas W. Kruckeberg
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Editor information

Editors and Affiliations

  1. Department of Experimental Medicine and Biochemical Sciences II, University of Rome, Via Orazio Raimondo, 00173, Rome, Italy

    Fiorenzo Battaini  & Marco Trabucchi  & 

  2. Department of Pharmacobiology, University of Bari, Via Re David 4, 70100, Bari, Italy

    Stefano Govoni

  3. Institute of Pharmacological Sciences, Faculty of Pharmacology, University of Milano, Via Balzaretti, 9, 20133, Milano, Italy

    Maria Sandra Magnoni

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© 1989 Springer-Verlag Berlin Heidelberg

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Burns, E.M., Kruckeberg, T.W. (1989). The Ultrastructural Basis of Capillary Permeability. In: Battaini, F., Govoni, S., Magnoni, M.S., Trabucchi, M. (eds) Regulatory Mechanisms of Neuron to Vessel Communication in the Brain. NATO ASI Series, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74152-4_1

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  • DOI: https://doi.org/10.1007/978-3-642-74152-4_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74154-8

  • Online ISBN: 978-3-642-74152-4

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