Muscarinic Inhibition of Adenylate Cyclase Activity in Rabbit Retinal Cells
Intracellular cyclic AMP levels can be increased or decreased by specific agonists (Gilman, 1987). Levels of cAMP can be reduced by two possible mechanisms, either by inhibition of adenylate cyclase (AC) via the activation of specific guanine nucleotide binding proteins (Gi) (Gilman, 1987) or by increasing the rate of cyclic nucleotide degradation via activation of cAMP phosphodiesterase (Harden et al., 1986). It has been reported that cholinergic muscarinic receptors decrease cAMP production via both inhibitory mechanisms (Harden et al., 1986).
KeywordsDopamine Adenosine Retina Acetylcholine Haloperidol
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