Muscarinic Inhibition of Adenylate Cyclase Activity in Rabbit Retinal Cells

  • H. Ghazi
  • N. N. Osborne
Conference paper
Part of the NATO ASI Series book series (volume 31)


Intracellular cyclic AMP levels can be increased or decreased by specific agonists (Gilman, 1987). Levels of cAMP can be reduced by two possible mechanisms, either by inhibition of adenylate cyclase (AC) via the activation of specific guanine nucleotide binding proteins (Gi) (Gilman, 1987) or by increasing the rate of cyclic nucleotide degradation via activation of cAMP phosphodiesterase (Harden et al., 1986). It has been reported that cholinergic muscarinic receptors decrease cAMP production via both inhibitory mechanisms (Harden et al., 1986).


Adenylate Cyclase Muscarinic Receptor Vasoactive Intestinal Peptide Inositol Phosphate Adenylate Cyclase Activity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. Ghazi
    • 1
  • N. N. Osborne
    • 1
  1. 1.Nuffield Laboratory of OphthalmologyOxford UniversityOxfordEngland

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