Muscarinic Inhibition of Adenylate Cyclase Activity in Rabbit Retinal Cells
Intracellular cyclic AMP levels can be increased or decreased by specific agonists (Gilman, 1987). Levels of cAMP can be reduced by two possible mechanisms, either by inhibition of adenylate cyclase (AC) via the activation of specific guanine nucleotide binding proteins (Gi) (Gilman, 1987) or by increasing the rate of cyclic nucleotide degradation via activation of cAMP phosphodiesterase (Harden et al., 1986). It has been reported that cholinergic muscarinic receptors decrease cAMP production via both inhibitory mechanisms (Harden et al., 1986).
KeywordsAdenylate Cyclase Muscarinic Receptor Vasoactive Intestinal Peptide Inositol Phosphate Adenylate Cyclase Activity
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- Cohen JL, Dcwling JE (1982) Effects of 6-hydroxy-dopamine on the spatial properties of carp horizontal cells. Soc Neurosci Abstr 8: 132Google Scholar
- Ghazi H, Osborne NN (1988b) Agonist induced glycogenolysis in rabbit retinal slices and cultures. British J Pharmacol (In Press)Google Scholar
- Harden TK, Tanner LI, Martin MW, Nakahata N, Hughes AR, Hepler JR, Evans T, Masters SB, Brown JH (1986) Characteristics of two biochemical responses to stimulation of muscarinic cholinergic receptors. TIPS Suppl: 14–18Google Scholar
- Katada T, Kusakabe K, Oinuma M, Ui M (1987) A novel mechanism for the inhibition of adenylate cyclase via inhibitory OTP-binding proteins. J Biol Chan 262: 11897–11900Google Scholar
- Neyton J, Piccolino M, Gerschenfeld HM (1982) Dopamine ( DA) and drugs that increase intracellular cyclic AMP decrease junctional cxmmunication between L-horizontal cells. Soc Neurosci Abstr 8: 132Google Scholar
- Piccolino M, Neyton J, Witkovsky P, Gerschenfeld HM (1982) gainna-Aminobutyric acid antagonists decrease junctional carmunication between L-horizontal cells in the retina. PNAS USA 79: 3671–3675Google Scholar