Abstract
The enzyme, protein kinase C (PKC), has been found to be destributed throughout mammalian tissues, its highest amounts being present in the CNS (Minakuchi et al, 1981; Kikkawa et al, 1982). Recent immunohistochemistry with poly- and mono-antisera against PKC has shown that its cellular distribution varies with cell type (Girard et al, 1985; Shoji et al, 1986; Wood et al, 1986; Saito et al, 1988). In the present study, an indirect immunohistochemical technique was applied to the retina of several vertebrates to explore the cellular localization of PKC-like immunoreactivity (IR).
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References
Coons AH (1958) Fluorescent antibody methods. In: Damielli JF (ed) General cytochemical methods. Academic, New York, pp 399–422
Dacheux RF, Raviola E (1986) The rod pathway in the rabbit retina; a depolarizing bipolar and amacrine cell. J Neurosci 6: 331–345
Dowling JE, Ehinger B (1975) Synaptic organization of the amine-containing interplexiform cells of the goldfish and cebus monkey retinas. Science 188: 270–273
Famiglietti EV (1983) ‘Starburst’ amacrine cells and cholinergic neurons: mirror-symmertic ON and OFF amacrine cells of rabbit retina. Brain Res 261:138–144
Girard PR, Mazzei GJ, Wood JG, Kuo JF (1985) Polyclonal antibodies to phospho1ipid/Ca2+-dependent protein kinase C and immunocytochemical localization of the enzyme in rat brain. Proc Natl Acad Sci USA 82: 3030–3034
Hatanaka H, Arimatsu Y (1984) Monoclonal antibodies to tyro-sine hydroxylase from rat pheochromocytoma PC12h cells with special reference to nerve growth factor-mediated increase of the immunoprecipitable enzymes. Neurosci Res 1: 253–263
Ishita S, Kato S (1987) Functional significance of protein kinase C in neural retina in particular reference to neurotransmitter release. Jpn J Pharmacol 90: 30 P
Ishita S, Negishi K, Teranishi T, Shimada Y, Kato S (1988) GABAergic inhibition on dopamine cells of the fish retina: a [3H]-dopamine release study with isolated cell fractions. J Neurochem 50: 1–6
Katayama-Kumoi Y, Kiyama H, Emson PC, Kimmel JR, Tohyama M (1985) Coexistence of pancreatic polypeptide and substance P in the chicken retina. Brain Res 361: 25–35
Kikkawa U, Takai Y, Minakuchi S, Inohara S, Nishizuka Y (1982) Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties. J Biol Chem 257: 13341–13348
Kiyama H, Katayama Y, Kimmel J, Steinbusch H, Smith D, Tohyama M (1985) Three dimensional analysis of retinal neuropeptides and amines. Brain Res Bull 15: 155–166
Kolb H, Nelson R (1985) Functional neurocircuitry of amacrine cells in the cat retina. In: Gallego A, Gouras P (eds) Neurocircuitry of the retina. Elsevier, New York, pp 215–232
Kolb H, Nelson R, Mariani A (1981) Amacrine cells, bipolar cells and ganglion cells of the cat retina: a Golgi study. Vision Res 21: 1081–1114.
Marc R, Liu LS (1984) Horizontal cell synapses onto glycine-accumulating interplexiform cells. Nature 311: 266–269
Mariani AP, Kolb H, Nelson R (1984) Dopamine-containing amacrine cells of rhesus monkey retina parallel rods in spatial distribution. Brain Res 322: 1–7
Mitrofanis J, Vigny A, Stone J (1988) Distribution of catechol a m i n e r g i c cells in the retina of the rat, guinea pig, cat, and rabbit: independence from ganglion cell distribution. J Comp Neurol 267: 1–14
Negishi K, Kato S, Teranishi, T (1982) Dopaminergic cells of the river lamprey retina revealed by a histof1uorescence study. Acta Histochem Cytochem 15: 757–767
Negishi K, Kato S, Teranishi, T (1988) Dopamine cells and rod bipolar cells contain protein kinase C-like immunoreactivity in some vertebrate retinas. Neurosci Lett (in press)
Negishi K, Kato S, Teranishi T, Kiyama H, Katayama Y, Tohyama M (1985) So-called interplexiform cells immunoreactive to tyrosine hydroxylase or somatostatin in rat retina. Brain Res 346: 136–140
Negishi K, Teranishi T (1987) A comparative study of immuno-reactive cells in cold-blooded vertebrate retinas. J Physiol Soc Jpn 49: 458
Negishi K, Teranishi T, Kato S (1983) A GABA antagonist, bicuculline, exerts its uncoupling action on external horizontal cells through dopamine cells in carp retina. Neurosci Lett 37: 261–266
Nelson R (1982) All amacrine cells quicken time course of rod signals in the cat retina. J Neurophysiol 47: 928–947
Nishizuka Y (1984) Turnover of inositolphospholipids and signal transduction. Science 255: 1365–1370
Nishizuka Y (1986) Studies and perspectives of protein kinase C. Science 233: 305–312
Pourcho RG (1982) Dopaminergic amacrine cells in the cat retina. Brain Res 252: 101–109
Pourcho RG, Goebel DJ (1985) A combined Golgi and autoradio-graphic study of (3H)glycine-accumulating amacrine cells in the cat retina. J Comp Neurol 233: 473–480
Saito N, Kikkawa U, Nishizuka Y, Tanaka C (1988) Distribution of protein kinase C-like immunoreactive neurons in rat brain. J Neurosci 8: 369–382
Shoji M, Girard PR, Mazzei GJ, Vogler WR, Kuo JF (1986) Immunocytochemical evidence for phorbol ester-induced protein kinase C translocation in HL60 cells. Biochem Biophys Res Commun 135: 1144–1149
Tachibana M, Kaneko A (1987) y-Aminobutyric acid exerts a local inhibitory action on the axon terminal of bipolar cells: evidence for negative feedback from amacrine cells. Proc Natl Acad Sci USA 84: 3501–3505
Takai Y, Kishimoto A, Kikkawa U, Mori T, Nishizuka Y. (1979) Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. Biochem Biophys Res Commun 90: 1218–1224
Teranishi T, Negishi K (1988) Regional difference in the dendritic morphology of dopaminergic cells in carp retina. Dev Brain Res 39: 9–17
Voigt T, Wässle H (1987) Dopaminergic innervation of AII amacrine cells in mammalian retina. J Neurosci 7: 4115–4128
Wood JG, Girard PR, Maaei GJ, Kuo JF (1986) Immunocytochemical location of protein kinase C in identified neuronal compartments of rat brain. J Neurosci 6: 2571–2577
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© 1989 Springer-Verlag Berlin Heidelberg
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Negishi, K., Kato, S., Teranishi, T. (1989). Immunocytochemical Localization of Protein Kinase C in some Vertebrate Retinas. In: Weiler, R., Osborne, N.N. (eds) Neurobiology of the Inner Retina. NATO ASI Series, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74149-4_33
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DOI: https://doi.org/10.1007/978-3-642-74149-4_33
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