Influence of Strontium Chloride on Blood Platelet Function

  • G. Togna
  • S. Gallozzi
  • L. Caprino
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Strontium appears to activate blood platelets by of its influx from a suspending medium (Blache et al 1987 a). Strong evidence that the same mechanism is activated by calcium throughout its channels, is however still lacking (Blache et al 1987 a; Blache et al 1987 b). This hypothesis derives from experiments carried out: a) on washed and resuspended platelets and not on intact platelets, as they are in platelet-rich plasma (PRP) and b) using thrombin as the only inducer of platelet reaction (Blache et al 1987a; Blache et al 1987b). Nevertheless, this data appears to be valid since, under the adopted experimental conditions, serotonin and thromboxane release was measured also in the presence or the absence of Ca2+ antagonists (Best et al 1981).

Keywords

Citrate Adenosine Serotonin Thrombin Strontium 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • G. Togna
    • 1
  • S. Gallozzi
    • 1
  • L. Caprino
    • 2
  1. 1.Institute of PharmacologyCatholic UniversityRomeItaly
  2. 2.IV Chair of PharmacologyUniversity La SapienzaRomeGermany

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