Study of Glutathione and Glutathione Related Enzymes in Acetaminophen-Poisoned Mice. Prevention by Anethole Trithione Pretreatment
For the general purpose of re-examining the pharmacological properties of the choleretic drug anethole trithione (Anethole dithiolthione = ADT), it was previously demonstrated that low dosage of ADT, administered p.o. 1 h prior to hepatotoxins, exhibited a marked hepatoprotective effect against carbon tetrachloride in rats and acetaminophen (AAP) in mice (Warnet et al 1987). Then, a preliminary kinetic study of the hepatoprotective effect of ADT was performed in mice.
KeywordsAminotransferase Activity Hepatoprotective Effect Mercapturic Acid Gamma Glutamylcysteine Chemoprotective Effect
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