Study of Glutathione and Glutathione Related Enzymes in Acetaminophen-Poisoned Mice. Prevention by Anethole Trithione Pretreatment

  • J.-M. Warnet
  • M.-O. Christen
  • M. Thevenin
  • D. Biard
  • A. Jacqueson
  • J.-R. Claude
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

For the general purpose of re-examining the pharmacological properties of the choleretic drug anethole trithione (Anethole dithiolthione = ADT), it was previously demonstrated that low dosage of ADT, administered p.o. 1 h prior to hepatotoxins, exhibited a marked hepatoprotective effect against carbon tetrachloride in rats and acetaminophen (AAP) in mice (Warnet et al 1987). Then, a preliminary kinetic study of the hepatoprotective effect of ADT was performed in mice.

Keywords

Glutathione Sedimentation Disulfide Hydroperoxide Acetaminophen 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ansher SS, Dolan P, Bueding E (1983) Chemoprotective effects of two dithiolthiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity. Hepatology 6: 932–935Google Scholar
  2. Ansher SS, Dolan P, Bueding E (1986) Biochemical effects of dithiolthiones. Food Chem Toxicol 24: 405–415PubMedCrossRefGoogle Scholar
  3. Carlberg I, Mannervik B (1985) Glutathione reductase. Meth Enzymol 113: 484–490PubMedCrossRefGoogle Scholar
  4. Davies MH, Blacker AM, Schnell RC (1987) Dithiolthione-induced alterations in hepatic glutathione and related enzymes in male mice. Biochem Pharmacol 36: 568–570PubMedCrossRefGoogle Scholar
  5. Griffith OW (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106: 207–212PubMedCrossRefGoogle Scholar
  6. Gunzler WA, Flohe L (1985) Glutathione peroxidase. In: Greenwald RA (ed) CRC Press Boca Raton Florida (CRC Handbook methods for oxygen radical research, p 285–290)Google Scholar
  7. Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130–7139PubMedGoogle Scholar
  8. Meister A (1984) New aspects of glutathione biochemistry and transport: selective alterations of glutathione metabolism. Fed Proc 43: 3031–3042PubMedGoogle Scholar
  9. Peterson GL (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83: 346–356PubMedCrossRefGoogle Scholar
  10. Seelig GF, Meister A (1985) Glutathione biosynthesis: gamma glutamylcysteine synthetase from rat kidney. Meth Enzymol 113: 379–390PubMedCrossRefGoogle Scholar
  11. Warnet JM, Christen MO, Thevenin M, Biard D, Jacqueson A, Claude JR (1987) Protective effect of anethole dithiolthione against carbon tetrachloride and acetaminophen hepatotoxicity in rodents. In: Revillard JP, Wierzbicki N (ed) Fondation Franco - Allemande Suresnes (Local Immunity. International Symposium series, vol 3, p 249–252)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J.-M. Warnet
    • 1
  • M.-O. Christen
    • 2
  • M. Thevenin
    • 1
  • D. Biard
    • 2
  • A. Jacqueson
    • 1
  • J.-R. Claude
    • 1
  1. 1.Laboratoire de ToxicologieFaculté de PharmacieParis CedexFrance
  2. 2.Laboratoires de Thérapeutique Moderne LTMSuresnes CedexFrance

Personalised recommendations