Detection of DNA-Protein Crosslinks in the Kidney of Male B6C3F1 Mice after Exposure to Methyl Chloride
Long-term exposure (two years) of male and female B6C3F1 mice to high concentrations (1000 ppm) of methyl chloride resulted in an increased incidence of renal tumours in males only (Batelle Columbus Laboratories, 1981). The question arose, whether this response was due to genetic or epigenetic factors. Alkaline elution was considered a suitable method for the detection of DNA damage which could provide an explanation for the observed sex difference.
KeywordsFormaldehyde Chrome Oncol Toxicology Hyde
Unable to display preview. Download preview PDF.
- Batelle Columbus Laboratories (1981): Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride submitted to the Chemical Industry Institute of Toxicology, Vol 1–4Google Scholar
- Ulsamer AG, Beall JR, Kang HK, Frazier JA (1984) Overview of health effects of formaldehyde. In: Hazard assessment of chemicals: current developments, Vol 3, pp 337–399Google Scholar