Detection of DNA-Protein Crosslinks in the Kidney of Male B6C3F1 Mice after Exposure to Methyl Chloride

  • C. Ristau
  • H. M. Bolt
  • R. R. Vangala
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Long-term exposure (two years) of male and female B6C3F1 mice to high concentrations (1000 ppm) of methyl chloride resulted in an increased incidence of renal tumours in males only (Batelle Columbus Laboratories, 1981). The question arose, whether this response was due to genetic or epigenetic factors. Alkaline elution was considered a suitable method for the detection of DNA damage which could provide an explanation for the observed sex difference.

Keywords

Formaldehyde Chrome Oncol Toxicology Hyde 

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References

  1. Batelle Columbus Laboratories (1981): Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride submitted to the Chemical Industry Institute of Toxicology, Vol 1–4Google Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • C. Ristau
    • 1
  • H. M. Bolt
    • 1
  • R. R. Vangala
    • 1
  1. 1.Abteilung für Toxikologie und ArbeitsmedizinInstitut für Arbeitsphysiologie an der Universität DortmundDortmund 1Germany

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