Ethylenethiourea as an Indicator of Exposure to Ethylenebisdithiocarbamate Fungicides

  • K. Savolainen
  • P. Kurttio
  • T. Vartiainen
  • J. Kangas
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Ethylenebisdithiocarbamates (EBDC) and their metabolite ethylenethiourea (ETU) are widely used in agriculture and forestry (EBDC) and rubber industry (ETU). EBDC and ETU are teratogenic and goitrogenic, and ETU is also carcinogenic in rodents (Fishbein 1976). However, congenital malformations or cases of thyroid cancer were not increased due to occupational exposure to ETU (Smith 1976). Ethylenediamine, a metabolite of EBDC, was not useful in monitoring of EBDC exposure (Kangas et al 1980), and measuring of ETU in urine by GLC (Newsome 1974) or HPLC (Lawrence et al 1981) have been problematic. Results are reported with a new and sensitive HPLC method which is useful in measuring of ETU in air or in urine of EBDC exposed workers (Kurttio et al 1988).

Keywords

HPLC Manganese Rubber Toxicology Dithiocarbamate 

Abbreviations

EBDC

Ethylenebisdithiocarbamate fungicides

ETU

Ethylenethiourea

HPLC

High pressure liquid chromatography

GLC

Gas liquid chromatography

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References

  1. Brocker ER, Schlatter (1979) Influence of some cations on the intestinal absorption of maneb. J Agric Food Chem 27: 303–306PubMedCrossRefGoogle Scholar
  2. Fishbein L (1976) Environmental health aspects of fungicides I. Dithiocarbamates. J Toxicol Environm Health 1: 713–735CrossRefGoogle Scholar
  3. Kangas J, Koskinen A, Husman K (1980) Exposure of Finnish forestry nursery workers to quintozene and maneb. In: Tordoir WR, van Heemstra EAH (eds.) Field worker exposure during pesticide application. Elsevier, New York, pp. 79–84Google Scholar
  4. Kurttio P, Vartiainen T, Savolainen K (1988) A high performance liquid chromatographic method for the determination of ethylenethiourea in urine and on filters. Analytica Chimica Acta, in pressGoogle Scholar
  5. Lawrence JF, Iverson F, Hanekamp HB, Bos P, Frei RW (1981) Liquid chromatography with UV absorbance and polarographic detection of ethylenethiourea and related sulfur compounds. J Chromatogr 212: 245–250PubMedCrossRefGoogle Scholar
  6. Nilsson CA, Nygren O (1987) Determination of mancozeb in air. Occupational exposure during its use in control of potato late blight. Chemosphere 16: 2423–2428CrossRefGoogle Scholar
  7. Smith D (1976) Ethylenethiourea - a study of possible teratogenicity and thyroid carcinogenicity. J Soc Occup Med 26: 92–94PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • K. Savolainen
    • 1
  • P. Kurttio
    • 1
  • T. Vartiainen
    • 1
  • J. Kangas
    • 2
  1. 1.Department of Environmental Hygiene and ToxicologyNational Public Health InstituteKuopioFinland
  2. 2.Kuopio Regional Institute of Occupational HealthKuopioFinland

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