Ethylenethiourea as an Indicator of Exposure to Ethylenebisdithiocarbamate Fungicides

  • K. Savolainen
  • P. Kurttio
  • T. Vartiainen
  • J. Kangas
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)


Ethylenebisdithiocarbamates (EBDC) and their metabolite ethylenethiourea (ETU) are widely used in agriculture and forestry (EBDC) and rubber industry (ETU). EBDC and ETU are teratogenic and goitrogenic, and ETU is also carcinogenic in rodents (Fishbein 1976). However, congenital malformations or cases of thyroid cancer were not increased due to occupational exposure to ETU (Smith 1976). Ethylenediamine, a metabolite of EBDC, was not useful in monitoring of EBDC exposure (Kangas et al 1980), and measuring of ETU in urine by GLC (Newsome 1974) or HPLC (Lawrence et al 1981) have been problematic. Results are reported with a new and sensitive HPLC method which is useful in measuring of ETU in air or in urine of EBDC exposed workers (Kurttio et al 1988).


Thyroid Cancer Potato Field Potato Late Blight Breathing Zone Potato Farm 
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Ethylenebisdithiocarbamate fungicides




High pressure liquid chromatography


Gas liquid chromatography


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • K. Savolainen
    • 1
  • P. Kurttio
    • 1
  • T. Vartiainen
    • 1
  • J. Kangas
    • 2
  1. 1.Department of Environmental Hygiene and ToxicologyNational Public Health InstituteKuopioFinland
  2. 2.Kuopio Regional Institute of Occupational HealthKuopioFinland

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