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Pharmacology of the Skin II pp 483–493Cite as

Pharmacology of Anti-androgens in the Skin

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 2))

Abstract

Anti-androgens are compounds which prevent androgens from expressing their activity at target sites (Dorfman 1970), and are therefore considered of potential therapeutic value in diseases where androgenic stimulation appears to play a pathogenic role. Thus, dermatological conditions involving hair follicles and sebaceous glands, such as androgenic alopecia, idiopathic hirsutism, acne and seborrhoea, where androgen involvement is recognised, should benefit from such therapy. Clinical experience in recent years, using systemic anti-androgens to treat females with these conditions, has been encouraging. In males, however, anti-androgen treatment has been restricted to male hypersexuality and tumours of the prostate (Neumann and Jacobi 1982) for obvious toxicological reasons.

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Authors
  1. D. S. Thomson
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Editors and Affiliations

  1. The Institute of Dermatology, St. Thomas’s Hospital, Lambeth Palace Road, SE1 7EH, London, Great Britain

    Malcolm W. Greaves M.D., Ph.D., F.R.C.P.

  2. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, Great Britain

    Sam Shuster M.D., Ph. D., F.R.C.P.

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© 1989 Springer-Verlag Berlin Heidelberg

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Thomson, D.S. (1989). Pharmacology of Anti-androgens in the Skin. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin II. Handbook of Experimental Pharmacology, vol 87 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74054-1_36

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  • DOI: https://doi.org/10.1007/978-3-642-74054-1_36

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  • Print ISBN: 978-3-642-74056-5

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