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Pharmacology of the Skin II pp 419–438Cite as

The Urticarias

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 2))

Abstract

Urticaria is characterised by wealing (localised oedema) with itching and erythema and results from localised vasodilatation and transudation of fluid from the dermal microvasculature. Deep spread of the fluid produces angio-oedema. Histologically there is dermal oedema, dilated small blood vessels and lymphatics and a sparse perivascular mixed cellular infiltrate (Ackerman 1968). The urticarial lesions usually subside within hours as the extravasated fluid is absorbed into the lymphatics. There are many precipitating causes of urticaria (Table 1) which induce a chain of events in the skin of susceptible subjects, with release of mediators which increase vascular permeability and thus cause wealing (Table 2).

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Authors
  1. A. Kobza Black
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Editors and Affiliations

  1. The Institute of Dermatology, St. Thomas’s Hospital, Lambeth Palace Road, SE1 7EH, London, Great Britain

    Malcolm W. Greaves M.D., Ph.D., F.R.C.P.

  2. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, Great Britain

    Sam Shuster M.D., Ph. D., F.R.C.P.

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© 1989 Springer-Verlag Berlin Heidelberg

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Black, A.K. (1989). The Urticarias. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin II. Handbook of Experimental Pharmacology, vol 87 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74054-1_31

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  • DOI: https://doi.org/10.1007/978-3-642-74054-1_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74056-5

  • Online ISBN: 978-3-642-74054-1

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