Abstract
Our modern way of life with its high levels of stress and anxiety has increased the salience of problems associated with insomnia and consequently also the search for drugs to alleviate this symptom. This review presents the most recent pharmacological data on two types of new sleep-improving drugs: (a) new hypnotics, which have proven active in humans, and (b) sleep modulators, which represent a speculative but interesting approach to the treatment of sleep disorders. We describe here compounds representative of each in terms of pharmacological profile and biochemical characteristics.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bénavides J, Camelin JC, Mitrani N, Flamand F, Uzan A, Legrand JJ, Gueremy C, Le Fur G (1985) 2-amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission. II. Neuropharmacology 24: 1085–1092
Billiard M, Besset A, De Lustrac C, Brissand L (1987) Dose-response effects of zopiclone on night sleep and on nightime and daytime functioning. Sleep 10 (suppl) 1: 27–34
Blagoeva P, Masi I, Scotti de Carolis A, Longo VG (1972) Amino acid release from the cerebral cortex of the rabbit, its relationship with the electrocorticogram. Physiol Behav 9: 307–313
Blanchard JC, Stutzmann JM (1988) Zopiclone (imovane) un nouvel hypnotique non benzodiazepinique: propriétés pharmacologiques et mecanisme d’action. Rev sci Méd 2: 65–81
Blanchard JC, Boireaua, Garret C, Julou L (1979) In vitro and in vivo inhibition by zopiclone of benzodiazepine binding to rodent brain receptors. Life Sci 24: 2417–2420
Blanchard JC, Boireau A, Julou L (1983 a) Brain receptors and zopiclone. Pharmacology 27 (Suppl) 2: 59–69
Blanchard JC, Zundel JL, Julou L (1983 b) Differences between cyclopyrrolones (suriclone and zopiclone) and benzodiazepines binding to rat hippocampus photolabelled membranes. Biochem Pharmacol 32: 3651–3653
Braestrup C, Nielsen M (1981) [3H]Propyl β-carboline-3-carboxylate as a selective radioligand for the BZD1 benzodiazepine receptor subclass. J Neurochem 37: 333–341
Chéramy A, Romo R, Godeheu G, Baruch P, Glowinski J (1986) In vivo presynaptic control of dopamine release in the cat caudate nucleus. II. Facilitory or inhibitory influence of L-glutamate. Neuroscience 19: 1081–1090
Cook L, Davidson AB (1973) Effects of behaviourally active drugs in a conflict punishment procedure in rats. In: Garattini S, Mussini E, Randall LO (eds) The benzodiazepines. Raven, New York, pp 327–345
Declerck AC, Wauquier PHM, Van der Ham-Veltman, Gelders Y (1987) Increase of slow wave sleep in human volunteers by the serotonin S2 2 2 2 2 2 2 antagonist ritanserin. Curr Ther Res 41: 427–432
Depoortere H, Zivkovic B, Lloyd KG, Sanger DJ, Perrault G, Langer SZ, Bartholini G (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects. J Pharmacol Exp Ther 237: 649–658
Depoortere H, Decobert M, Riou-Merle F, Granger P (1988) Pharmaco-EEG profile of Zolpidem: an imidazopyridine hypnotic agent. In: Sauvanet JP, Langer SZ, Morselli PL (eds) Imidazopyridines in sleep disorders. Raven, New York, pp 81–96
Disbrow JK, Ruth J A (1984) Differential glutamate release in brain regions of long sleep and short sleep mice. Alcohol 1: 201–203
Doble A, Hubert JP, Perrier ML (1987) The pharmacology of an excitatory amino acid receptor. Br J Pharmacol 91: 23
Dugovic C, Wauquier A (1987) 5-HT2 receptors could be primarily involved in the regulation of slow wave sleep in the rat. Eur J Pharmacol 137: 145–146
Geller I, Seifter J (1960) The effects of meprobamate, barbiturates D-amphetamine and promazine on experimentally induced conflict in the rat. Psychopharmacology 1: 482–492
Hollister LE (1973) Antianxiety drugs in clinical practice. In: Garettini S, Mussini E, Randall LO (eds) The benzodiazepines. Raven, New York, pp 367–377
Idzikowski C, Mills FJ, Glennard R (1986) 5-Hydroxytryptamine-2 antagonist increases human slow wave sleep. Brain Res 378: 164–168
Janssen PAJ (1988) The relevance of pharmacological studies to sleep research in psychiatry. Pharmacopsychiatry 21: 33–37
Jasper H, Koyama I (1969) Rate of release of amino acids from the cerebral cortex in the cat affected by brainstem and thalamic stimulation. Can J Physiol Pharmacol 47: 889–905
Jouvet M (1983) Mecanismes des etats de sommeil. In: Benoit O (ed) Physiologie du sommeil. Masson, Paris, pp 1–18
Julou L, Bardone MC, Blanchard JC, Garret C, Stutzmann JM (1983) Pharmacological studies on zopiclone. Pharmacology 27: 46–58
Julou L, Blanchard JC, Dreyfus JF (1985) Pharmacological and clinical studies of cy-clopyrrolones: zopiclone and suriclone. Pharmacol Biochem Behav 23: 653–659
Klepner CA, Lippa AS, Benson DI, Sano MC, Beer B (1979) Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors. Pharmacol Biochem Behav 11: 457–462
Langer SZ, Arbilla S (1988) Limitations of the benzodiazepine receptor nomenclature: a proposal for a pharmacological classification as omega receptor subtypes. Fundam Clin Pharmacol 2: 159–170
Langer SZ, Depoortere H, Sanger D, George P, Zivkovic B, Arbilla S, Lloyd KG, Bartholini G (1985) Biochemical and pharmacological profile of SL 80.0759–23 N, a new short acting hypnotic. J Neurochem 44: S179
Leysen JE, Gommeren W, Van Gompel P, Wynants J, Janssen PFM, Laduron P (1985) Receptor-binding properties in vitro and in vivo of ritanserin. Mol Pharmacol 27: 600–611
Lippa AS, Jackson D, Wennogle LP, Beer B, Meyerson LR (1982) Non-benzodiazepine antagonists for benzodiazepine receptors. In: Usdin E, Skolnick P, Tallman JF, Greenblett D, Paul SM (eds) Pharmacology of benzodiazepines. MacMillan Press, London, pp 431 - 440
Marks J (1980) The benzodiazepine use and abuse. Arzneimittelforschung/Drug Res 30: 388–390
Michel F, Klein M, Jouvet D, Valatx JL (1961) Etude polygraphique du sommeil chez le rat. C R Soc Biol (Paris) 155: 2389–2392
Mizoule J, Meldrum B, Mazadier M, Croucher M, Ollat C, Uzan A, Legrand JJ, Guérémy C, Le Fur G (1985) 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission. I. Anticonvulsant properties. Neuropharmacology 24: 767–773
Möhler H, Okada T (1977) Benzodiazepine receptor: demonstration in the central nervous system. Science 198: 849–851
Rataud J, Bardone MC, Stutzmann JM, Mazadier M, Uzan A, Blanchard JC, Laduron P (1988) Riluzole (PK 26124) induces discriminative stimuli in rats. Psychopharmacology 96 (Suppl): 373
Radulovacki M, Virus RM, Djuricic-Nedelson M, Green RD (1983) Adenosine analogs and sleep in rats. J Pharmacol Exp Ther 228: 268–274
Scatton B, Claustre Y, Dennis T, Nishikawa T (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. II. Effects on cerebellar cyclic GMP levels and cerebral monoamines. J Pharmacol Exp Ther 237: 659–665
Schofield PR, Darlison MG, Fujita N, Burt DR, Stephenson FA, Rodriguez M, Rhee LM, Ramachadran J, Reale V, Glencorse TA, Seeburg PH, Barnard EA (1987) Sequence and functional expression of the GABAa receptor shows a ligand-gated receptor super-family. Nature 328: 221–227
Snyder SH (1987) GABA-benzodiazepine receptor complex: focus on receptor subtypes and Cyclopyrrolone drugs. Isr J Med Sci 23: 145–152
Squires RF, Braestrup C (1977) Benzodiazepine receptor in rat brain. Nature 266: 732–734
Stutzmann JM, Lucas M, Blanchard JC, Laduron PM (1988 a) Riluzole, a glutamate antagonist, enhances slow wave and REM sleep in rats. Neurosci Lett 88: 195–200
Stutzmann JM, Laduron PM, Blanchard JC ( 1988 b) Sleep enhancing effect of riluzole in rats and cats. 9th European congress of sleep research, Jérusalem, Abstracts, p 207
Zivkovic B, Perrault G, Morel E, Sanger DJ (1988) Comparative pharmacology of Zolpidem and other hypnotics and sleep inducers. In: Sauvanet JP, Langer SZ, Morselli PL (eds) Imidazopyridines in sleep disorders. Raven, New York, pp 97–110
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Stutzmann, J.M., Laduron, P.M., Blanchard, J.C. (1990). Pharmacology of New Sleep-Improving Drugs. In: Bunney, W.E., Hippius, H., Laakmann, G., Schmauss, M. (eds) Neuropsychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74034-3_64
Download citation
DOI: https://doi.org/10.1007/978-3-642-74034-3_64
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74036-7
Online ISBN: 978-3-642-74034-3
eBook Packages: Springer Book Archive