Sympathetic Noradrenergic Neural Contacts with Lymphocytes and Macrophages in the Splenic White Pulp of the Rat: Site of Possible Bidirectional Communication and Local Regulation Between the Nervous and Immune Systems

  • S. Y. Felten
  • D. L. Felten
Conference paper


Evidence from many fields of investigation points toward communication between the nervous and immune systems in both directions (Ader 1981; Goetzl 1985; Guillemin et al. 1985; Jankovic et al. 1987). Numerous psychosocial factors can influence immune responses. Specific stressors in rodents are associated with altered immune responses and sometimes with altered resistance to tumors or pathogens. Discrete lesions in hypothalamic and limbic regions of the central nervous system (CNS) can result in transient or long-lasting changes in specific measures of immune reactivity (see Felten and Felten 1987 for discussion). Although these studies indicate the existence of communication between the nervous system and the immune system, they do not reveal the pathways or the mechanisms by which this is accomplished.


Tyrosine Hydroxylase Nerve Terminal White Pulp Electron Microscopic Level Marginal Sinus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • S. Y. Felten
  • D. L. Felten
    • 1
  1. 1.Department of Neurobiology and AnatomyUniversity of Rochester School of MedicineRochesterUSA

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