Abstract
Various neuroendocrinological studies with the clonidine (CLON; Table 1) and desmethylimipramine (DMI) growth hormone (GH) stimulation tests showed a blunted GH response in endogenous depressives and in patients with major affective disorders. According to preliminary studies, the blunted GH response to CLON seems to be a trait marker or vulnerability factor for endogenous depression. Since GH responses to CLON and DMI are α2-adrenoceptor mediated, some authors have discussed the possibility of an α2-adrenoceptor subsensitivity to be responsible for the blunted GH response in endogenous depressive patients (for review see Matussek 1988).
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© 1990 Springer-Verlag Berlin Heidelberg
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Matussek, N. (1990). α2-Adrenoceptor Interaction with Opiate Receptors. In: Bunney, W.E., Hippius, H., Laakmann, G., Schmauss, M. (eds) Neuropsychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74034-3_30
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DOI: https://doi.org/10.1007/978-3-642-74034-3_30
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