α2-Adrenoceptor Interaction with Opiate Receptors

  • N. Matussek
Conference paper


Various neuroendocrinological studies with the clonidine (CLON; Table 1) and desmethylimipramine (DMI) growth hormone (GH) stimulation tests showed a blunted GH response in endogenous depressives and in patients with major affective disorders. According to preliminary studies, the blunted GH response to CLON seems to be a trait marker or vulnerability factor for endogenous depression. Since GH responses to CLON and DMI are α2-adrenoceptor mediated, some authors have discussed the possibility of an α2-adrenoceptor subsensitivity to be responsible for the blunted GH response in endogenous depressive patients (for review see Matussek 1988).


Growth Hormone Depressive Patient Growth Hormone Response Opiate Receptor Opiate Withdrawal 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • N. Matussek
    • 1
  1. 1.Psychiatrische KlinikUniversität MünchenMünchen 2Germany

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