Abstract
There is ample evidence indicating that the central nervous system and the immune system are functionally linked. The exact mode of neural — immune interaction is still not certain, however the presence of specific neurotransmitter receptors on these cells appears to be important in mediating an intracellular event which could then lead to alterations in immune function. Several receptors for neurotransmitters in lymphocytes have been described, such as β-adrenergic receptors (Williams et al. 1976), muscarinic receptors (Strom et al. 1981), specific receptors for endorphines (Hazum et al. 1979), and even dopaminergic receptors (LeFur et al. 1980; Uzan et al. 1981; Ovadia and Abramsky 1987; Ebstein 1988).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bidart JM, Motte P, Assicot M, Bohuon C, Bellet D (1983) Catechol-O-methyltransferase activity and aminergic binding sites distribution in human peripheral blood lymphocyte subpopulations. Clin Immunol Immunopathol 26: 1–9
Bondy B, Ackenheil M, Birzle W, Elbers R, Frôhler M (1984) catecholamines and their receptors in blood: evidence for alterations in schizophrenia. Biol Psychiatry 19: 1377–1393
Bondy B, Ackenheil M, Elbers R, Frôhler M (1985) Binding of 3H-spiperone to lymphocytes: a biological marker in schizophrenia? Psychiatry Res 15: 41–48
Brockington I (1986) Diagnosis of schizophrenia and schizoaffective psychoses. In: Bradley PB, Hirsch SR (eds) The psychopharmacology and treatment of schizophrenia. A British Association of Pharmacology Monograph. Cambridge University Press, Cambridge
Carlsson A (1988) The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1 (3): 179–203
Czlonkowski A, Czlonkowska A (1984) Reduced binding of 3H-spiroperidol to lymphocytes in Wilson’s disease. Acta Neurol Scand 69: 298–301
Ebstein RP (1988) Characterization of a D1 dopamine receptor in cell membranes from fresh human lymphocytes and EBV transformed lymphoblastoid cells: stereospecific, saturable and high affinity binding of 125I-SCH 23982. Psychopharmacology [Suppl], vol 96: 65
Hassan MN and Thakar JH (1988) Dopamine receptors in Parkinson’s disease. Prog Neuropsychopharmacol Biol Psychiatry 12: 173–18
Hazum E, Chang KJ, Cuatrecasas P (1979) Specific nonopiate receptors for β-endorphines. Science 205: 1033–1035
Kouassi E, Revillard JP (1987 a) Contribution of β-adrenoceptors to the dopamine induced elevation of cyclic 3,5-adenosine monophosphate levels in mouse lymphocytes. Eur J Pharmacol 144: 97–100
Kouassi E, Li YS, Flacher M, Revillard JP (1987b) Cyclic adenosine 3,5-monophosphate response to dopamine in mouse lymphoid cells and cell lines. Life Sci 40: 2385–2392
LeFur G, Phan T, Uzan A (1980) Identification of stereospecific 3H-spiroperidol binding sites in mammalian lymphocytes. Life Sci 26: 1139–1148
LeFur G, Perrot JY, Boucheix C, Phan T, Flamier A, Burgevin MC, Driancourt C, Goldblum N, Rosenfeld C, Uzan A (1981a) 3H-spiroperidol binding sites, a new marker for haematopoetic differentiation. Hum Lymphocyte Diff 1: 153–158
LeFur G, Phan T, Canton T, Tur C, Uzan A (1981b) Evidence for a coupling between dopaminergic receptors and phospholipid methylation in mouse B-lymphocytes. Life Sci 29: 2737–2749
LeFur G, Zarifian E, Phan T, Cuche H, Flamier A, Bouchami A, Burgevin MC, Loo H, Gerard A, Uzan A (1983) 3H-spiperone binding in lymphocytes: changes in two different groups of schizophreneics and effect of neuroleptic treatment. Life Sci 32: 245–249
Maloteaux PM, Waterkein C, Laduron PM (1982) Absence of dopamine and muscarinic receptors on human lymphocytes. Arch Int Pharmacodyn Ther 258: 174–176
Maloteaux JM, Laterre CE, Hens L, Laduron PM (1983) Failure of peripheral dopaminergic marker in Parkinson’s disease. J Neurol Neurosurg Psychiatry 46: 1146–1148
Oertel WH (1987) Parkinson Syndrom und andere Erkrankungen der Basalganglien (EPMS Erkrankungen). In: Elger CE, Dengler R (eds) Jahrbuch der Neurologie 1987. Biermann, Regensburg, pp 91–103
Ovadia H, Abramsky O (1987) Dopamine receptors on isolated membranes of rat lymphocytes. J Neurosci Res 18: 70 - 74
Owens DGC, Johnstone EC, Crow TJ, Frith CD, Jagoe JR, Kreel L (1985) Lateral ventricular size in schizophrenia, relationship to the disease process and its clinical manifestations. Psychol Med 15: 27–41
Perrot JY, Boucheix C, LeFur G, Flamier A, Bernadoux A, Uzan A, Rosenfeld C (1983) Detection of binding sites for spiroperidol on leukemic cells: its value for the phenotype characterization of lymphoid cells. Leuk Res 7 (3): 349–355
Rotstein E, Mishra RK, Signal DP, Barone D (1983) Lymphocyte 3H-spiroperidol binding in schizophrenia: preliminary findings. Prog Neuropsychopharmacol Biol Psychiatry 7: 720–723
Seeman P (1987) Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1: 133–152
Shaskan EG, Ballow M, Oreland L, Wadell G (1983) Is there a functional significance for dopamine antagonist binding sites on lymphoid cells? Adv Biol Psychiatry 12: 123–141
Shaskan EG, Ballow M, Lederman M, Margoles SL, Melchreit R (1984) Spiroperidol binding sites on mouse lymphoid cells: effects of ascorbic acid and psychotropic drugs. J Neuroimmunol 6:59–66
Stepien H, Kunert-Radek J, Karasek E, Pawlikowski M (1981) Dopamine increases cyclic AMP concentration in the rat spleen lymphocytes in vitro. Biochem Biophys Res Commun 101 (3): 1057–1063
Strom TB, Lane MA, George R (1981) The parallel, time dependent bimodal change in lymphocyte cholinergic binding activity and cholinergic influence upon lymphocyte mediated cytotoxicity after lymphocyte activation. J Immunol 127: 705–710
Uzan A, Phan T, LeFur G (1981) Selective labelling of murine B-lymphocytes by 3H- spiroperidol. J Pharm Pharmacol 33: 102–103
Wazer DE, Rotrosen J (1984) Murine lymphocytes lack clearly defined receptors for muscarinic and dopaminergic ligands. J Pharm Pharmacol 36: 853–854
Williams LT, Snyderman R, Lefkowitz RJ (1976) Identification of β-adrenergic receptors in human lymphocytes by (—)3H-alprenolol binding. J Clin Invest 57: 149–155
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Bondy, B., Peuker, B., Ackenheil, M. (1990). [3H] Spiperone Binding to Lymphocytes in Psychiatric Disorders. In: Bunney, W.E., Hippius, H., Laakmann, G., Schmauss, M. (eds) Neuropsychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74034-3_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-74034-3_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74036-7
Online ISBN: 978-3-642-74034-3
eBook Packages: Springer Book Archive