Recognition by Human B Cells of Foreign Antigen in the Context of the MHC: a Review
The experimental evidence for the existence of human B cells that recognize foreign antigen in the context of the MHC is very restricted, not to say limited to only one example (Van Leeuwen et al. 1979), at least with regard to the known nature of the MHC allele and the antigen involved. On the other hand in exerimental animal models, the number of antigen specific MHC restricted antibodies reported (see the detailed descriptions by different authors in this volume) greatly exceeds one, though it does not reach overwhelming levels. Nevertheless, the independent observations strongly support the notion that MHC restricted antibodies do exist, although with special regard to the human studies more data are needed to strengthen the evidence for the existence of such antibodies in man.
KeywordsForeign Antigen Associative Recognition Specific CTLs Antigen Specific CTLs Heavy Polypeptide Chain
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