Models for MHC-Restricted T Cell Recognition of a Synthetic H-2Ld Peptide
Class I and class II major histocompatibility (MHC) antigens are polymorphic cell surface glycoproteins which play central roles in controlling target cell recognition by antigen specific cytotoxic and helper T cells. The class I molecules are expressed ubiquitously and, in general, are involved in the presentation of intracellular and cell surface viral antigens to cytotoxic T-lymphocytes (CTLs). On the other hand, class II molecules are expressed primarily on antigen presenting cells such as macrophages and B cells, where they are involved in the presentation of phagocytized or internalized foreign antigens to helper T cells (Zinkernagel and Doherty 1979; Schwartz 1984). As a rule, T cells exhibit an obligatory requirement of corecognition of antigen and MHC antigen of their own haplotype or “restriction element.” Therefore, T cell recognition is said to be “MHC restricted.”
KeywordsCell Recognition Restriction Element Specific CTLs Polymorphic Residue Viral Specific CTLs
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