MHC + X pp 206-213 | Cite as

Models for MHC-Restricted T Cell Recognition of a Synthetic H-2Ld Peptide

  • Elizabeth S. Song
  • Richard Linsk
  • Robert S. Goodenow
Conference paper


Class I and class II major histocompatibility (MHC) antigens are polymorphic cell surface glycoproteins which play central roles in controlling target cell recognition by antigen specific cytotoxic and helper T cells. The class I molecules are expressed ubiquitously and, in general, are involved in the presentation of intracellular and cell surface viral antigens to cytotoxic T-lymphocytes (CTLs). On the other hand, class II molecules are expressed primarily on antigen presenting cells such as macrophages and B cells, where they are involved in the presentation of phagocytized or internalized foreign antigens to helper T cells (Zinkernagel and Doherty 1979; Schwartz 1984). As a rule, T cells exhibit an obligatory requirement of corecognition of antigen and MHC antigen of their own haplotype or “restriction element.” Therefore, T cell recognition is said to be “MHC restricted.”


Cell Recognition Restriction Element Specific CTLs Polymorphic Residue Viral Specific CTLs 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Elizabeth S. Song
    • 1
  • Richard Linsk
    • 1
  • Robert S. Goodenow
    • 1
  1. 1.Department of GeneticsUniversity of CaliforniaBerkeleyUSA

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