Biochemistry of HLA-B27 in Transfected Cells and Transgenic Mice
To study the functional properties of HLA molecules, genes encoding these proteins have been isolated and used to transfect mouse cells. We have isolated the genes encoding the HLA-B27k and -B27w proteins (Seemann et al. 1986). A number of diseases are associated with certain HLA alleles. Of these associations, the one linking the HLA-B27 alleles with ankylosing spondylitis is the most pronounced. Several models have been presented over the past few years to explain this fact. However, the lack of a proper model system to study this HLA disease association has restricted the experimental basis for these theories. Transgenic mice may provide us with a better defined model system to study the immunobiology of HLA-B27 and — together with biochemical analysis of the HLA-B27 gene product — may give us better insight into HLA disease association.
KeywordsTransgenic Mouse Ankylose Spondylitis Heavy Chain Human Class Free Heavy Chain
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