Abstract
Work from many laboratories has demonstrated the existence in bone marrow of a multipotent stem cell able to give rise to progeny in all of the hematopoietic lineages (Abramson et al 1977, Dick et al 1985, Keller et al 1985). Studies on the differentiation of myeloid cells have demonstrated that among the progeny of multipotent stem cells are stem cells with restricted differentiation potential (Abramson et al 1977). The spleen colony-forming stem cell (CFU-S)(Till and McCulloch 1961) produces myeloid and erythroid progeny but lacks the ability to produce lymphocytes (Paige et al 1979). The existence of a similar lymphoid-restricted stem cell remains controversial. In studies on the reconstitution of irradiated animals or mutant mice with normal bone marrow cells, most groups detect the pluripotent stem cells, Sp (see Fig. 1) (Abramson et al 1977, Keller et al 1985, Lemischka et al 1986), myeloid-restricted stem cells, SM (Abramson et al 1977) and CFU-S (Wu et al 1968), but no one has yet convincingly identified a lymphoid-restricted stem cell,SL, in normal bone marrow. Fig. 1 shows a differentiation scheme assuming that restricted stem cells exist.
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References
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© 1988 Springer-Verlag Berlin · Heidelberg
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Phillips, R.A., Wu, DD., Fulop, G.M. (1988). Lymphoid-Restricted Stem Cells. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1988. Current Topics in Microbiology and Immunology, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74006-0_2
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DOI: https://doi.org/10.1007/978-3-642-74006-0_2
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