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Bursal Stem Cells as Targets for myc-Induced Preneoplastic Proliferation and Maturation Arrest

  • P. E. Neiman
  • E. B. Gehly
  • L. M. Carlson
  • R. C. Cotter
  • C. B. Thompson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 141)

Abstract

Induction of lymphomas in the bursa of Fabricius of chickens by replication competent, non-transforming avian retroviruses (Avian Leukosis Virus, ALV) is both an economically significant, naturally occurring disease and an experimental model system which has provided seminal insights into the role of the myc oncogene in B-cell neoplasia. Infection of the bursa of susceptible birds results in the development of lymphomas in a series of specific stages beginning with a preneoplastic proliferation of pyroninophilic B-lymphoblasts within individual bursal follicles, a lesion termed a transformed follicle (Cooper et al. 1968, Neiman et al. 1980a). Transformed follicles appear to be precursors of discrete bursal nodules and, later, metastasizing lymphomas (Neiman et al. 1980a, 1980b, Baba and Humphries 1985). These advanced lesions are clonal neoplasms (Neiman et al. 1980b) in which the expression of the c-myc proto-oncogene has been deregulated as a result of the nearby integration of an ALV provirus (Hayward et al. 1981).

Keywords

Follicle Cell Maturation Arrest Avian Leukosis Virus Normal Follicle Primary Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • P. E. Neiman
    • 1
  • E. B. Gehly
    • 1
  • L. M. Carlson
    • 2
  • R. C. Cotter
    • 1
  • C. B. Thompson
    • 2
  1. 1.Division of Basic Sciences, Fred Hutchinson Cancer Research Center and the Departments of Medicine, Pathology and Laboratory MedicineUniversity of WashingtonSeattleUSA
  2. 2.Howard Hughes Medical Inst.University of MichiganAnn ArborUSA

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