Bursal Stem Cells as Targets for myc-Induced Preneoplastic Proliferation and Maturation Arrest
Induction of lymphomas in the bursa of Fabricius of chickens by replication competent, non-transforming avian retroviruses (Avian Leukosis Virus, ALV) is both an economically significant, naturally occurring disease and an experimental model system which has provided seminal insights into the role of the myc oncogene in B-cell neoplasia. Infection of the bursa of susceptible birds results in the development of lymphomas in a series of specific stages beginning with a preneoplastic proliferation of pyroninophilic B-lymphoblasts within individual bursal follicles, a lesion termed a transformed follicle (Cooper et al. 1968, Neiman et al. 1980a). Transformed follicles appear to be precursors of discrete bursal nodules and, later, metastasizing lymphomas (Neiman et al. 1980a, 1980b, Baba and Humphries 1985). These advanced lesions are clonal neoplasms (Neiman et al. 1980b) in which the expression of the c-myc proto-oncogene has been deregulated as a result of the nearby integration of an ALV provirus (Hayward et al. 1981).
Unable to display preview. Download preview PDF.
- Neiman PE, Jordan L, Weiss RA, Payne LN (1980a) Malignant lymphoma of the bursa of Fabricius: Analysis of early transformation. In: Viruses in Naturally Occuring Cancers, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, p 519–527.Google Scholar
- Thompson CB, Challoner PB, Neiman PE (1986) Normal and neoplastic B-cell development in the bursa of Fabricius. In: Current Topics in Microbiology and Immunology, vol 132, Springer-Verlag Berlin-Heidlberg, pp 209–214.Google Scholar
- Weill J-C, Leibowitch M, Reynaud C-A (1987) Questioning the role of the embryonic bursa in molecular differentiation of B lymphocytes. In: Current Topics in Microbiology and Immunology, vol. 135, Springer-Verlag Berlin-Heidlberg, pp 111–124.Google Scholar