Bursal Stem Cells as Targets for myc-Induced Preneoplastic Proliferation and Maturation Arrest
Induction of lymphomas in the bursa of Fabricius of chickens by replication competent, non-transforming avian retroviruses (Avian Leukosis Virus, ALV) is both an economically significant, naturally occurring disease and an experimental model system which has provided seminal insights into the role of the myc oncogene in B-cell neoplasia. Infection of the bursa of susceptible birds results in the development of lymphomas in a series of specific stages beginning with a preneoplastic proliferation of pyroninophilic B-lymphoblasts within individual bursal follicles, a lesion termed a transformed follicle (Cooper et al. 1968, Neiman et al. 1980a). Transformed follicles appear to be precursors of discrete bursal nodules and, later, metastasizing lymphomas (Neiman et al. 1980a, 1980b, Baba and Humphries 1985). These advanced lesions are clonal neoplasms (Neiman et al. 1980b) in which the expression of the c-myc proto-oncogene has been deregulated as a result of the nearby integration of an ALV provirus (Hayward et al. 1981).
KeywordsFollicle Cell Maturation Arrest Avian Leukosis Virus Normal Follicle Primary Recipient
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