Increase in ICP Produced by Electrical Stimulation of the Brain Stem Reticular Formation in Cats with Spinalization and Vagotomy
The effects of focal electrical stimulation on intracranial pressure (ICP) and arterial blood pressure (ABP) have been extensively examined by applying the stimulus to the brain stem (Maeda et al. 1985, Maeda et al. 1986, Matsuura et al. 1986, Maeda et al. 1988a), cerebral cortex and hypothalamus (Maeda et al. 1986, Maeda et al. 1988b) in cats. The early change in ICP produced by the electrical stimulation was explained by the change in cerebral blood volume (CBV) due to neurogenic cerebral vasodilatation or constriction and by the change in the driving pressure associated with the stimulus-induced alteration of ABP and respiratory movement (Maeda et al. 1988a). The ABP and respiration can be maintained at normal levels during electrical stimulation in spinalized and vagotomized cats. Therefore, the present study was undertaken to explore the changes in ICP in response to brain stem activation by focal electrical stimulation in spinalized and vagotomized cats in order to deduce the locations in the brain stem reticular formation which are related to cerebral vasodilatation.
KeywordsArterial Blood Pressure Intracranial Pressure Cerebral Blood Volume Reticular Formation Cerebral Vasodilatation
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