Reduction of Intracranial Hypertension with Free Radical Scavengers
Intracranial hypertension after severe head injury continues to remain a serious problem affecting morbidity and mortality. Excluding space occupying lesions, the etiology of raised ICP is due to either vascular engorgement (brain swelling) or brain edema. Engorgement occurs when there is a loss of the normal regulation of vascular tone, resulting in cerebrovascular dilatation. Brain edema can occur from increased vascular permeability, producing a vasogenic component of extracellular fluid. Free radical scavengers have demonstrated protective effects against both dilatation and increased permeability of the cerebral vasculature in response to various experimental insults. Based on this evidence, it was postulated that prevention of free radical mediated injury might attenuate the development of intracranial hypertension.
KeywordsFree Radical Scavenger Brain Edema Intracranial Hypertension Mean Arterial Blood Pressure Severe Head Injury
Unable to display preview. Download preview PDF.
- Chan P, Fishman RA, Longar S (1986) Liposome-entrapped superoxide following traumatic brain injury. Soc Neurosci Abst 12:38Google Scholar
- Zimmerman RS, Muizelaar JP, Wei EP, Kontos HA (1987) Acute cerebral arteriolar responses following cold injury. In: Cervos-Nevarro J, Ferszt R (eds) Stroke and microcirculation. Raven Press, New York, pp 303–309Google Scholar