Reduction of Intracranial Hypertension with Free Radical Scavengers
Intracranial hypertension after severe head injury continues to remain a serious problem affecting morbidity and mortality. Excluding space occupying lesions, the etiology of raised ICP is due to either vascular engorgement (brain swelling) or brain edema. Engorgement occurs when there is a loss of the normal regulation of vascular tone, resulting in cerebrovascular dilatation. Brain edema can occur from increased vascular permeability, producing a vasogenic component of extracellular fluid. Free radical scavengers have demonstrated protective effects against both dilatation and increased permeability of the cerebral vasculature in response to various experimental insults. Based on this evidence, it was postulated that prevention of free radical mediated injury might attenuate the development of intracranial hypertension.
KeywordsPermeability Superoxide Assure Catalase Mannitol
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