Abstract
Tenascin from chick embryos is an extracellular matrix protein with disulfide-linked subunits of Mr = 190–220,000 and a six-armed appearance in the electron microscope (EM) (cf. Chiquet-Ehrismann et al 1988). Its expression during development suggests a function in morphogenesis (Chiquet-Ehrismann et al 1986). Several activities of tenascin can be assayed in vitro: hemagglutination, interference with fibronectin-mediated cell spreading, promotion of neurite outgrowth, and stimulation of DNA synthesis (Chiquet-Ehrismann et al 1986, 1988, Chiquet 1989). We are trying to assign various functions to specific domains on the molecule.
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References
Chiquet-Ehrismann R, Mackie EJ, Pearson CA, Sakakura T (1986) Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis. Cell 47: 131–139
Chiquet-Ehrismann R, Kalla P, Pearson CA, Beck K, Chiquet M (1988) Tenascin interferes with fibronectin action. Cell 53: 383–390
Chiquet M (1989) Tenascin/J1/cytotactin: the potential function of hexabrachion proteins in neural development. Dev. Neurosci., in press
Pearson CA, Pearson D, Shibahara S, Hofsteenge J, Chiquet-Ehrismann R (1988) Tenascin: cDNA cloning and induction with TGF. EMBO J 7: 2677
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© 1989 Springer-Verlag Berlin Heidelberg
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Chiquet, M., Schenk, S., End, P., Beck, K., Pearson, C., Chiquet-Ehrismann, R. (1989). Functional Domains of Tenascin. In: Aebi, U., Engel, J. (eds) Cytoskeletal and Extracellular Proteins. Springer Series in Biophysics, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73925-5_24
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DOI: https://doi.org/10.1007/978-3-642-73925-5_24
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