Nimodipine and Neural Plasticity in the Peripheral Nervous System of Adult and Aged Rats

  • W. H. Gispen
  • T. Schuurman
  • J. Trabe
Part of the Bayer AG Centenary Symposium book series (BAYER)


Neural plasticity as defined in this contribution is the capability of the nervous system to adapt to a changing internal or external environment, to previous experience, or to trauma. It is becoming increasingly clear that the nervous system is not a static, but rather a dynamic network of cells allowing adaptive changes at all levels of complexity. These can be studied at the molecular, morphological, neurophysiological, and behavioral level. Neural plasticity is an essential and central feature of adaptation. Nervous system plasticity is of great significance in relation to a number of important health-related problems, such as peripheral nerve, spinal cord, and brain injury, developmental disorders, learning disabilities, and dementia. Profound insight into the mechanism of neural plasticity is a prerequisite for advances in the therapy of these pathologies (Gelijns et al. 1987).


Sciatic Nerve Peripheral Nervous System Axonal Regeneration Nerve Conduction Velocity Neural Plasticity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Akers RF, Lovinger DM, Colley PA, Linden DJ, Routtenberg A (1986) Translocation of protein kinase C activity may mediate hippocampal long-term potentiation. Science 231:587–589PubMedCrossRefGoogle Scholar
  2. Bär PR, Wiegant F, Lopes da Silva FH, Gispen WH (1984) Tetanic stimulation affects the metabolism of phosphoinositides in hippocampal slices. Brain Res 321:381–385PubMedCrossRefGoogle Scholar
  3. Belleman P, Schade A, Towart R (1983) Dihydropyridine receptor in rat brain labelled with PH]nimodipine. Proc Natl Acad Sci USA 80:2356CrossRefGoogle Scholar
  4. Benowitz L, Shaskoua V, Yoon MG (1981) Specific changes in rapidly transported proteins during regeneration of the gold fish optic nerve. J Neurosci 1:300–307PubMedGoogle Scholar
  5. Betz E, Deck K, Hoffmeister F (1985) Nimodipine: pharmacological and clinical properties. Schattauer, StuttgartGoogle Scholar
  6. Bijlsma WA, Jennekens FGI, Schotman P, Gispen WH (1983) Stimulation by ACTH (4–10) of nerve fiber regeneration following sciatic nerve crush. Muscle Nerve 6:104–112PubMedCrossRefGoogle Scholar
  7. Coper H, Jänicke B, Schulze G (1986) Biopsychological research on adaptivity across the life-span of animals. In: PD Baltes, Featherman DL, Lerner RM (eds) Life-span development and behavior. Erlbaum, Hillsdale pp 207–232Google Scholar
  8. De Graan PNE, Oestreicher AB, Schrama LH, Gispen WH (1986) Phosphoprotein B-50: localization and function. Progr Brain Res 69:37–50CrossRefGoogle Scholar
  9. De Koning P, Brakkee JH, Gispen WH (1986) Methods for producing a reproducible crush in the sciatic and tibial nerve of the rat and rapid and precise testing of return of sensory function. J Neurol Sci 74:237–241PubMedCrossRefGoogle Scholar
  10. De Koning P, Gispen WH (1988) A rationale for the use of melanocortins in the treatment of nervous tissue damage. In: Stein DG, Sabel B (eds) Pharmacological approaches to the treatment of brain and spinal cord injuries. Plenum New York (in press)Google Scholar
  11. De Medinacelli L, Freed WJ, Wyatt RJ (1982) An index of the functional condition of rat sciatic nerve based on measurements made from walking trades. Exp Neurol 77:634–643CrossRefGoogle Scholar
  12. Gage FH, Björklund A, Stenevi U, Dunnett SB (1983) Intracerebral grafting in the aging brain. In: Gispen WH, Traber J (eds) Aging of the brain. Elsevier, AmsterdamGoogle Scholar
  13. Gage FH, Dunnett StB, Björklund A (1984) Spatial learning and motor deficits in aged rats. Neurobiol Age 5:43–48CrossRefGoogle Scholar
  14. Gelijns AC, Graaff PJ, Lopes da Silva FH, Gispen WH (1987) Future health care applications resulting from progress in the neurosciences: the significance of neural plasticity research. Health Policy 8:265–276.CrossRefGoogle Scholar
  15. Landfield PW (1983) Mechanisms of altered neural function during aging. Dev Neurol 7:51–71Google Scholar
  16. Landfield PW, McGaugh JL, Lynch G (1978) Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats. Brain Res 150:85PubMedCrossRefGoogle Scholar
  17. Landfield PW, Baskin RK, Pitler TA (1981) Brain aging correlates: retardation by hormonal pharmacological treatments. Science 214:581–584PubMedCrossRefGoogle Scholar
  18. Lynch G, Baudry M (1984) The biochemistry of memory: a new and specific hypothesis. Science 224:1057–1063PubMedCrossRefGoogle Scholar
  19. Lynch G, Larson J, Kelso S, Barrionuevo G, Schottler F (1983) Intracellular injections of EGTA block induction of hippocampal long-term potentiation. Nature 305:719–721PubMedCrossRefGoogle Scholar
  20. Ramon y Cajal S (1928) Degeneration and regeneration of the nervous system. Hafner, New YorkGoogle Scholar
  21. Schuurman T, Klein H, Beneke M, Traber J (1987) Nimodipine and motor deficits in the aged rats. Neurosci Res Commun 1:9–15Google Scholar
  22. Skene JHP, Willard M (1981) Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells. J Cell Bioi 89:86–95CrossRefGoogle Scholar
  23. Tielen AM, Mollevanger WJ, Lopes da Silva FH, Hollander CF (1983) Neuronal plasticity in hippocampal slices of extremely old rats. Dev Neurol 7:73–84Google Scholar
  24. Varon S (1985) Factors promoting the growth of the nervous system. Neurosciences 3:62Google Scholar
  25. Van der Zee CEEM, Schuurman T, Traber J, Gispen WH (1987) Oral administration ofnimodipine accelerates functional recovery following peripheral nerve damage in the rat. Neurosci Lett 83:143–148PubMedCrossRefGoogle Scholar
  26. Willard M, Skene JHP (1982) Molecular events in axonal regeneration. In: A Nicholls (ed) Repair and regeneration of the nervous system. Springer, Heidelberg, pp 71–89CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • W. H. Gispen
    • 1
  • T. Schuurman
    • 2
  • J. Trabe
    • 2
  1. 1.Rudolf Magnus Institute for Pharmacology and Institute of Molecular Biology and Medical BiotechnologyUniversity of UtrechtUtrechtThe Netherlands
  2. 2.Neurobiology Department, TroponwerkeKölnGermany

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