Protein Kinase C and Protein F1: Potential Molecular Mediators of Lesion-Induced Synaptic Plasticity Recapitulate Developmental Plasticity
This review is focused on the suggestion that a potential molecular mechanism involving protein kinase C and its substrate protein F1 may be directly involved in the process of mediating lesion-induced neuronal plasticity. As several chapters in this Volume illustrate, after damage to the nervous system, intact neurons show growth activities such as axonal sprouting. Under certain conditions this can lead to recovery of function, in whole or in part. The mechanisms for this process are not known, though some recent clues from biochemistry suggest particular proteins that may be essential for the process. In this review I wish to emphasize one essential point: that the input-dependent molecular mechanism related to synaptic growth of intact synapses is also recruited by injury-produced growth factors that stimulate the response to nerve injury.
KeywordsNeurite Outgrowth Growth Cone Phorbol Ester Perforant Path Synaptic Growth
Unable to display preview. Download preview PDF.
- Lovinger DM, Akers RF, Nelson RB, Barnes CA, McNaughton BL, Routtenberg A (1985 a) A selective increase in the phosphorylation of protein F1, a protein kinase C substrate, directly related to three day growth of long term synaptic enhancement. Brain Res 343: 137–143Google Scholar
- Nelson RB, Routtenberg A, Hyman C, Pfenninger KH (1985) A phosphoprotein, F1, directly related to neuronal plasticity in adult rat brain may be identical to a major growth cone membrane protein. Soc Neurosci Abstr 11: 927Google Scholar
- Routtenberg A (1982) Memory formation as a posttranslational modification of brain proteins. In: Marsden CA, Matthies H (eds) Mechanisms and models of neural plasticity. Proc Vlth Intl Neurobiol IBRO Symposium on Learning and Memory. Raven, New York, pp 17–24Google Scholar
- Routtenberg A (1984) Brain phosphoproteins kinase C and protein Fl: Protagonists of plasticity in particular pathways. In: Lynch G, McGaugh J, Weinberger N (eds) Neurobiology of learning and memory. The Guilford Press, New York, pp 479–490Google Scholar
- Routtenberg A, Ehrlich YH, Rabjohns R (1975) Effect of a training experience on phosphorylation of a specific protein in neocortical and subcortical membrane preparations. Fed Proc 34: 293Google Scholar
- Routtenberg A, Lovinger D, Cain S, Akers R, Steward O (1983) Effects of long-term potentiation of perforant path synapses in the intact hippocampus on in vitro phosphorylation of a 47 KD protein (F-1). Fed Proc 42: 755Google Scholar
- Skene JHP, Willard M (1981 a) Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells. J Cell Biol 89: 86–95Google Scholar
- Skene JHP, Willard M (1981 c) Characteristics of growth-associated polypeptides in regenerating toad retinal ganglion cell axons. J Neurosci 1: 419–426Google Scholar