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Central and Cerebellar Norepinephrine Depletion and Vestibulo-ocular Reflex (VOR) Adaptation

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Post-Lesion Neural Plasticity

Abstract

Adaptation of the vestibulo-ocular reflex (VOR) presents an attractive model for investigating neural plasticity in the central nervous system because a great deal is known about the neural organization that is responsible for its operation. Modifications in the gain of the VOR can be brought about by a mismatch of visual and vestibular inputs. This can be accomplished by modifying vision with reversing prisms (Gonshor and Melvill Jones 1976), magnifying or reducing lenses (Miles and Fuller 1974; Demer and Robinson 1982), or by altering the normal visual environment in other ways to produce a conflict between the two senses (Ito et al. 1974; Maioli and Precht 1984). The result is an adjustment of the gain of the VOR that allows this reflex to continue to carry out its primary function, i.e., to maintain an image of visual interest on the fovea of the eye in the presence of head movements. This reflex has a well-established time course during which adaptation takes place. Modifications to the gain of the VOR occur within a relatively short period (1–2 h) and can be maintained over an extended period of time (days to weeks).

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, 19140, USA

    J. G. McElligott

  2. Department of Electrical and Computer Engineering, Drexel University, Philadelphia, PA, 19104, USA

    W. Freedman

Authors
  1. J. G. McElligott
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  2. W. Freedman
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Editor information

Editors and Affiliations

  1. Dept. of Neurobiology, University of Bremen, NW2, Postfach 330440, D-2800, Bremen 33, Federal Republic of Germany

    Hans Flohr

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© 1988 Springer-Verlag Berlin Heidelberg

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McElligott, J.G., Freedman, W. (1988). Central and Cerebellar Norepinephrine Depletion and Vestibulo-ocular Reflex (VOR) Adaptation. In: Flohr, H. (eds) Post-Lesion Neural Plasticity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73849-4_59

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  • DOI: https://doi.org/10.1007/978-3-642-73849-4_59

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73851-7

  • Online ISBN: 978-3-642-73849-4

  • eBook Packages: Springer Book Archive

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