Sprouting Pattern and B-50 Phosphorylation in Regenerating Sciatic Nerve Respond to ACTH Peptides
Nerve sprouting in regeneration occurs as a restorative process following nerve crush or section. During regeneration, the administration of ACTH or ACTH peptide fragments such as αMSH (ACTH 1–13), ACTH 4–10, or an analogue of ACTH 4–9 (Org. 2766), stimulates the formation of nerve sprouts. The accelerated return of motor and sensory function following treatment with ACTH peptides (Strand and Kung 1980; Bijlsma et al. 1983) is due to an earlier initiation of sprouting following crush denervation (Verhaagen et al. 1986 a). Reinnervated motor units formed under the influence of early peptide treatment are considerably smaller, thus permitting finer motor control, than in saline-treated animals (Saint-Come and Strand 1985, 1987). This suggests an organizational role for these peptides on the pattern by which regenerating axons reinnervate skeletal muscle.
KeywordsSciatic Nerve Motor Unit Nerve Terminal Molecular Weight Calibration ACTH Peptide
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