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Post-Lesion Neural Plasticity pp 605–614Cite as

Sprouting Pattern and B-50 Phosphorylation in Regenerating Sciatic Nerve Respond to ACTH Peptides

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Abstract

Nerve sprouting in regeneration occurs as a restorative process following nerve crush or section. During regeneration, the administration of ACTH or ACTH peptide fragments such as αMSH (ACTH 1–13), ACTH 4–10, or an analogue of ACTH 4–9 (Org. 2766), stimulates the formation of nerve sprouts. The accelerated return of motor and sensory function following treatment with ACTH peptides (Strand and Kung 1980; Bijlsma et al. 1983) is due to an earlier initiation of sprouting following crush denervation (Verhaagen et al. 1986 a). Reinnervated motor units formed under the influence of early peptide treatment are considerably smaller, thus permitting finer motor control, than in saline-treated animals (Saint-Come and Strand 1985, 1987). This suggests an organizational role for these peptides on the pattern by which regenerating axons reinnervate skeletal muscle.

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Author information

Authors and Affiliations

  1. Center for Neuroscience, New York University, Washington Square, New York, USA

    F. L. Strand, L. A. Zuccarelli, B. Kirschenbaum & R. E. Frischer

Authors
  1. F. L. Strand
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  2. L. A. Zuccarelli
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  3. B. Kirschenbaum
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  4. R. E. Frischer
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Editor information

Editors and Affiliations

  1. Dept. of Neurobiology, University of Bremen, NW2, Postfach 330440, D-2800, Bremen 33, Federal Republic of Germany

    Hans Flohr

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© 1988 Springer-Verlag Berlin Heidelberg

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Strand, F.L., Zuccarelli, L.A., Kirschenbaum, B., Frischer, R.E. (1988). Sprouting Pattern and B-50 Phosphorylation in Regenerating Sciatic Nerve Respond to ACTH Peptides. In: Flohr, H. (eds) Post-Lesion Neural Plasticity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73849-4_53

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  • DOI: https://doi.org/10.1007/978-3-642-73849-4_53

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73851-7

  • Online ISBN: 978-3-642-73849-4

  • eBook Packages: Springer Book Archive

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