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Produktion der Radionuklide und Herstellung markierter Verbindungen

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PET

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Zusammenfassung

Der Stand der Technik zur 15O-Produktion ist kürzlich zusammenfassend dargestellt worden (Clark et al. 1987). Die weitaus meist verwendete Kernreaktion zur Darstellung von 15O ist die 14N(d,n) 15O-Reaktion. Da sie keine Schwellenenergie hat, können auch Beschleuniger mit niedriger Deuteronenenergie völlig ausreichende Aktivitätsmengen an 15O erzeugen. Reine Protonenbeschleuniger müssen dagegen auf die 15N (p,n) 15O-Reaktion zurückgreifen, die ein angereichertes Nuklid als Targetmaterial benötigt. Eine Rückgewinnung ist technisch sehr aufwendig oder sogar (bei direkter on-line Beatmung des Patienten) unmöglich. Die Anregungsfunktion der Deuteronenreaktion zeigt, daß niedrige Deuteronenenergien vorzuziehen sind, um die Produktion von anderen Nukliden (13N, 11C) möglichst zu unterdrücken. Aufgrund der kurzen Halbwertszeit des 15O können nur einfache Verbindungen durch Festphasenumsetzung oder sehr schnelle Chemie hergestellt werden. Weiterhin kann mit einer Synthese aus dem gleichen Grund nur eine Patientenmessung durchgeführt werden. Die maximal applizierten Aktivitäten liegen bei 50–100 mCi. Mit den beschriebenen Verfahren können Aktivitäten bis zu 500 mCi bei Bestrahlungsende ohne Schwierigkeiten produziert werden.

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Authors and Affiliations

  1. MPI für neurologische Forschung, Ostmerheimer Str. 200, 5000, Köln 91, Deutschland

    Professor Dr. Klaus Wienhard, Dr. Rainer Wagner & Professor Dr. Wolf-Dieter Heiss

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  1. Professor Dr. Klaus Wienhard
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  2. Dr. Rainer Wagner
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  3. Professor Dr. Wolf-Dieter Heiss
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© 1989 Springer-Verlag Berlin Heidelberg

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Wienhard, K., Wagner, R., Heiss, WD. (1989). Produktion der Radionuklide und Herstellung markierter Verbindungen. In: PET. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73843-2_4

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  • DOI: https://doi.org/10.1007/978-3-642-73843-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73844-9

  • Online ISBN: 978-3-642-73843-2

  • eBook Packages: Springer Book Archive

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