Nα-Acetylation of Eukaryotic Proteins: Purification and Characterization of Yeast Nα-Acetyltransferase and Acetylcoenzyme A Hydrolase
Nα-acetylation is the most common N-terminal modification of eukaryotic proteins, but its physiological significance is still an enigma. Many proteins are known to be Nα-acetylated (Tsunasawa and Sakiyama 1984; Driessen et al 1985). For example, > 80% of the intracellular, soluble proteins in mouse L-cells and Ehrlich ascites cells are Nα-acetylated (Brown and Roberts 1976; Brown 1979). Although the biological role of Nα-acetylation in protein degradation and protein secretion has been investigated, much is still unknown.
KeywordsEukaryotic Protein Protein Sequence Analysis Catabolize Amino Acid Ehrlich Ascites Cell Yeast Alcohol Dehydrogenase
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