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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 1))

Abstract

Mammalian epidermis is a renewing tissue which provides the outer surface coat of the body. The high impermeability of the stratum corneum membrane and its physical strength protect the body against external influences and maintain the milieu intérieur. Besides representing the continuous supply of cells forming the external barrier (the stratum corneum), epidermal cells have been shown to possess a number of additional functional capabilities as listed in Table 1.

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References

  • Ackerman AB (1978) Histologic diagnosis of inflammatory skin diseases. Lea and Febiger, Philadelphia

    Google Scholar 

  • Allen T, Potten C (1975) Desmosomal form, fate, and functions in mammalian epidermis. J Ultrastruct Res 51:94–105

    Article  CAS  PubMed  Google Scholar 

  • Allen TD, Potten C (1976) Ultrastructural site variations in mouse epidermal organization. J Cell Sci 21:341–359

    CAS  PubMed  Google Scholar 

  • Anton-Lamprecht I (1973) Zur Ultrastruktur hereditärer Verhornungsstorungen:III. Autosomal dominante Ichthyosis vulgaris. Arch Dermatol Forsch 248:149–156

    Article  CAS  PubMed  Google Scholar 

  • Baker H, Kligman AM (1967) Technique for estimating turnover time of human stratum corneum. Arch Dermatol 95:408

    Article  CAS  PubMed  Google Scholar 

  • Bandmann HJ (1980) Makroskopische Anatomie der Haut. In:Korting GW (ed) Dermatologie in Praxis und Klinik, vol 1. Thieme, Stuttgart, pp 1.1–1.11

    Google Scholar 

  • Banks-Schlegel S, Green H (1981) Involucrin synthesis and tissue assembly by keratinocytes in natural and cultured human epithelia. J Cell Biol 90:732–737

    Article  CAS  PubMed  Google Scholar 

  • Bauer FW, Crombar NHCMN, De Grood RM, De Jongh GJ (1980) Flow cytometry as a tool for the study of cell kinetics in epidermis. Br J Dermatol 102:629–639

    Article  CAS  PubMed  Google Scholar 

  • Bergstresser PR, Taylor JR (1977) Epidermal “turnover time” — a new examination. Br J Dermatol 96:503–509

    Article  CAS  PubMed  Google Scholar 

  • Birbeck MS, Breathnach AS, Everall JD (1961) An electron microscopic study of basal melanocytes and high level clear cell ( Langerhans cell) in vitiligo. J Invest Dermatol 37:51–64

    Google Scholar 

  • Bizzozero G (1870) Osservazione sulla structura degli epiteli pavimentosi stratificrate. Rend r 1st Lombardo 3:675

    Google Scholar 

  • Bloom W, Fawcett OW (1975) A textbook of histology, 10th edn. Saunders, Philadelphia

    Google Scholar 

  • Braun-Falco O (1965) Die Histochemie der Barriere. In:Lejhanec G, Hybasek P (eds) De structura et functione stratorum epidermis s.d. barrierae. Lékarská Fakulta University U.E. Parkyne, Brünn, pp 49–61

    Google Scholar 

  • Breathnach AS (1981) Application of freeze-fracture replication to study of hyperkeratosis. In:Marks R, Christophers E (eds) The epidermis in disease. MTP Press, Lancaster, pp 31–43

    Google Scholar 

  • Briggaman RA (1981) Basement membrane formation and origin with special reference to skin. Front Matrix Biol 9:142–155

    CAS  Google Scholar 

  • Briggaman RA (1982) Biochemical composition of the epidermal-dermal junction and other basement membranes. J Invest Dermatol 78:1–6

    Article  CAS  PubMed  Google Scholar 

  • Briggaman RA, Wheeler CE (1975) The epidermal-dermal junction. J Invest Dermatol 65:71–84

    Article  CAS  PubMed  Google Scholar 

  • Brody I (1959) The keratinization of epidermal cells of normal guinea pig skin as revealed by electron microscopy. J Ultrastruct Res 2:4822–493

    Article  Google Scholar 

  • Brody I (1977) Ultrastructure of the stratum corneum. Int J Dermatol 16:245–257

    Article  CAS  PubMed  Google Scholar 

  • Brophy D, Lobitz WC (1959) Injury and reinjury to human epidermis. J Invest Dermatol 32:495

    Article  CAS  PubMed  Google Scholar 

  • Bucher O (1980) Cytologie, Histologie und Mikroskopische Anatomie des Menschen, 10th edn. Huber, Bern

    Google Scholar 

  • Bullough WS (1972a) The control of epidermal thickness. Br J Dermatol 87:187–199

    Article  CAS  PubMed  Google Scholar 

  • Bullough WS (1976 b) The control of epidermis thickness. Br J Dermatol 87:347–354

    Article  Google Scholar 

  • Bullough WS, Mitrani E (1976) An analysis of the epidermal chalone control mechanism. In:Chalones. Houck JC (ed) Chalones. North-Holland, New York, pp 7–36

    Google Scholar 

  • Bullough WS, Stolze J (1978) A new form of cellular arrangement in guinea-pig ear epidermis. Br J Dermatol 99:519–525

    Article  CAS  PubMed  Google Scholar 

  • Caputo R, Peluchetti D (1977) The junctions of normal human epidermis. J Ultrastruct Res 61:44–61

    Article  CAS  PubMed  Google Scholar 

  • Caputo R, Gasparini G, Innocenti M (1981) Normal and abnormal keratinization processes. A freeze-fracture study. In:Marks R, Christophers E (eds) The epidermis in disease. MTP Press, Lancaster, pp 43–61

    Google Scholar 

  • Chopra DP, Flaxman BA (1972) Human epidermal cell cycle in vitro. Br J Dermatol 87:13–17

    Article  CAS  PubMed  Google Scholar 

  • Christophers E (1970) Eine neue Methode zur Darstellung des stratum corneum. Arch Klin Exp Derm 237:717–721

    Article  CAS  PubMed  Google Scholar 

  • Christophers E (1971 a) Die epidermale Columnarstruktur. Z Zellforsch 114:441–450

    Article  CAS  PubMed  Google Scholar 

  • Christophers E (1971 b) Cellular architecture of the stratum corneum. J Invest Dermatol 56:165–169

    Article  CAS  PubMed  Google Scholar 

  • Christophers E (1972 a) Correlation between columns formation, thickness and rate of new cell production in guinea pig epidermis. Virchows Arch [B] 10:286–292

    CAS  Google Scholar 

  • Christophers E ( 1972 b) Kinetic aspects of epidermal healing. In:Maibach HI, Rovee D (eds) Epidermal wound healing. Year Book Publishers, Chicago, pp 53–69

    Google Scholar 

  • Christophers E ( 1980 a) Epidermopoese und Keratinisation. In:Korting GW (Hrsg) Dermatologie in Praxis und Klinik, vol 1. Thieme, Stuttgart, pp 164–167

    Google Scholar 

  • Christophers E ( 1980 b) Structural aspects of mammalian epidermal growth. In:Spearman RIC, Riley PA (eds) The skin of vertebrates. Academic Press, London, pp 137–139

    Google Scholar 

  • Christophers E, Braun-Falco O (1971) Fluorescein-isothiocyanate as a stain for keratinizing epithelia. Arch Derm Forsch 241:199–209

    Article  CAS  Google Scholar 

  • Christophers E, Kligman AM (1964) Percutaneous absorption in aged skin. In:Montagna W (ed) Advances in biology of skin, vol VI. Pergamon, London, pp 163–175

    Google Scholar 

  • Christophers E, Laurence EB (1973) Regional variations in mouse skin:quantitation of epidermal compartments in two different body sites. Virchows Arch [B] 12:212–222

    CAS  Google Scholar 

  • Christophers E, Laurence EB (1976) Kinetics and structural organisation of the epidermis. Curr Probl Dermatol 6:87–106

    CAS  PubMed  Google Scholar 

  • Christophers E, Laurence EB (1980) Architectural considerations of epidermal growth. Pharmacol Ther 10:329–336

    Article  CAS  PubMed  Google Scholar 

  • Christophers E, Wolff HH (1975) Differential formation of desmosomes and hemidesmosomes in epidermal cell cultures treated with retinoic acid. Nature 256:209–210

    Article  CAS  PubMed  Google Scholar 

  • Christophers E, Wolff HH, Laurence EB (1974) The formation of epidermal cell columns. J Invest Dermatol 62:555–559

    Article  CAS  PubMed  Google Scholar 

  • Cummins H (1942) The skin and mammary glands. In:Morris’ human anatomy, 10th edn. Blakeston, Philadelphia

    Google Scholar 

  • Cummins H (1946) Dermatoglyphics:significant patternings of the body surface. Yale J Biol Med 18:551–565

    CAS  PubMed  Google Scholar 

  • Cummins H (1964) Dermatoglyphics:a brief review. In:Montagna W, Lobitz CW (eds) The epidermis. Academic Press, New York, pp 375–385

    Google Scholar 

  • Daróczy J, Feldmann J (1981) Microfilaments of the human epidermal-dermal junction. Front Matrix Biol 9:155–174

    Google Scholar 

  • De Bersaques J (1975) Keratohyalin und Epidermisverhornung. Hautarzt 26:177–189

    PubMed  Google Scholar 

  • Delecluse C (1981) Keratohyaline synthesis. Front Matrix Biol 9:102–112

    Google Scholar 

  • Duffil M, Wright N, Shuster S (1976) The cell proliferation kinetics of psoriasis examined by three in vivo techniques. Br J Dermatol 94:355–362

    Article  Google Scholar 

  • Ebling FJG (1979) The normal skin. In: Rock A, Wilkinson DS, Ebling FJG (eds) Textbook of dermatology, vol 1, 3rd edn. Blackwell, Oxford, pp 5–31

    Google Scholar 

  • Ebling FJG, Rook A (1979) Disorders of keratinization. In: Rook A, Wilkinson DS, Ebling FJG (eds) Textbook of dermatology, vol 2, 3rd edn. Blackwell, Oxford, pp 12535–1315

    Google Scholar 

  • Elias PM (1981) Epidermal lipids membranes and keratinization. Int J Dermatol 20:1–19

    Article  CAS  PubMed  Google Scholar 

  • Elias P, Friend D (1975) The permeability barrier in mammalian epidermis. J Cell Biol 65:185–197

    Article  Google Scholar 

  • Elias P, Goerke J, Friend D (1977) Permeability barrier lipids:composition and influence on epidermal structure. J Invest Dermatol 69:535–547

    Article  CAS  PubMed  Google Scholar 

  • Elias P, Brown B, Goerke J (1979) Localization and composition of lipids in neonatal mouse stratum granulosum and stratum corneum. J Invest Dermatol 73:339–348

    Article  CAS  PubMed  Google Scholar 

  • Epstein WL, Maibach HT (1965) Cell renewal in human epidermis. Arch Dermatol 92:462–468

    Article  CAS  PubMed  Google Scholar 

  • Etoh H, Taguchi YH, Tabachnik J (1975) Movement of beta-irradiated epidermal basal cells to the spinous-granula layers in the absence of cell division. J Invest Dermatol 64:431–435

    Article  CAS  PubMed  Google Scholar 

  • Fawcett D (1981) The cell, 2nd edn. Saunders, Philadelphia

    Google Scholar 

  • Fisher LB (1968) Determination of the normal rate and duration of mitosis in human epidermis. Br J Dermatol 80:24–28

    Article  CAS  PubMed  Google Scholar 

  • Fisher LB, Wells GC (1968) The mitotic rate and duration in lesions of psoriasis and ichthyosis. Br J Dermatol 80:235–240

    Article  CAS  PubMed  Google Scholar 

  • Frindle E, Malaise E, Tubiana M (1968) Cell proliferation kinetics in five human solid tumors. Cancer 22:611–620

    Article  Google Scholar 

  • Gelfant S (1978) Understanding chemotherapy of psoriasis in terms of epidermal cell proliferation. Cell Tissue Kinet 11:577–579

    CAS  PubMed  Google Scholar 

  • Gorbsky G, Steinberg M (1981) Isolation of the intercellular glycoproteins of desmosomes. J Cell Biol 90:243–248

    Article  CAS  PubMed  Google Scholar 

  • Gray G (1981) Keratinization and the plasma membrane of the stratum corneum. Cell Front Matrix Biol 9:83–102

    CAS  Google Scholar 

  • Greb W (1940) Untersuchungen uber die Gestalt des Papillarkorpers der menschlichen Haut. Z Anat 110:245–263

    Google Scholar 

  • Greulich RC (1964) Aspects of cell individuality in the renewal of stratified squamous epithelium. In:Montagna W, Lobitz W (eds) The epidermis. Academic Press, New York, pp 117–133

    Google Scholar 

  • Gross RJ (1965) Kinetics of compensatory growth. Q Rev Biol 40:126–146

    Google Scholar 

  • Hadler W, Silveira S (1981) Identification of tocopherol (vitamin E) in the skin and its histochemical detection. Acta Histochem 68:11–21

    CAS  PubMed  Google Scholar 

  • Halprin KM (1972) Epidermal “turnover time” — a re-examination. Br J Dermatol 86:14–19

    Article  CAS  PubMed  Google Scholar 

  • Ham AW (1974) Histology, 7th edn. Lippincott, Philadelphia

    Google Scholar 

  • Hayward AF (1979) Membrane-coating granules. Int Rev Cytol 59:97–124

    Article  CAS  PubMed  Google Scholar 

  • Hill MW (1980) Cell kinetics in premalignancy. In:Mackenzie IC, Dabelsteen E, Squier Chr (eds) Oral premalignancy. University of Iowa Press, Iowa, pp 191–219

    Google Scholar 

  • Horstmann E (1957) Die Haut. In:Bargmann W (ed) Handbuch der mikroskopischen Anatomie des Menschen, vol 3/1. Springer, Berlin, Gottingen, Heidelberg, pp 1–276

    Google Scholar 

  • Hunter R, Pinkus H, Steele Ch (1956) Examination of the epidermis by the strip method. J Invest Dermatol 27:31–34

    Article  CAS  PubMed  Google Scholar 

  • Iversen OH, Bjerknes R, Devik F (1968) Kinetics of cell renewal, cell migration and cell loss in the hairless mouse dorsal epidermis. Cell tissue Kinet 1:351–367

    Google Scholar 

  • Jaoita H, Foidart J, Katz S (1978) Localization of the collagenous component in skin basement membrane. J Invest Dermatol 70:191–193

    Article  Google Scholar 

  • Kahn G, Weinstein GD, Frost P (1968) Kinetics of human epidermal cell proliferation:diurnal variation. J Invest Dermatol 50:459–462

    CAS  PubMed  Google Scholar 

  • Kakimi S, Fukuyama K, Epstein W (1980) A study of ultrathin frozen sections of granular cells in newborn rat epidermis. J Ultrastruct Res 70:8–14

    Article  CAS  PubMed  Google Scholar 

  • Katz SI, Tamaki K, Sachs DH (1979) Epidermal Langerhans cells are derived from cells originating in the bone marrow. Nature 282:324–326

    Article  CAS  PubMed  Google Scholar 

  • Kelly D, Luft J (1966) Fine structure development and classification of desmosomes and related attachment mechanism. In:Electron microscopy. 6th edn. International Congress on Electron Microscopy, Tokyo 2:401–402

    Google Scholar 

  • Kligman AM (1964) The biology of the stratum corneum. In:Montagna W, Lobitz GW (eds) The epidermis. Academic Press, New York, pp 387–430

    Google Scholar 

  • Landmann L (1980) Lamellar granules in mammalian, avian and reptilian epidermis. J Ultrastruct Res 72:245–263

    Article  CAS  PubMed  Google Scholar 

  • Langerhans P (1868) Uber die Nerven der menschlichen Haut. Virchows Arch Pathol Anat 44:325–337

    Article  Google Scholar 

  • Laurence EB, Christophers E (1976) Selective action of hydrocortisone on postmitotic epidermal cells in vivo. J Invest Dermatol 66:201–281

    Article  Google Scholar 

  • Leblond CP, Greulieh RC, Peirera JP (1964) Relationship of cell formation and cell migration in the renewal of stratified squamous epithelia. In:Montagna W, Billingham RB (eds) Advances in biology of skin, vol 5. Pergamon, Oxford, pp 39–66

    Google Scholar 

  • Leloup R, Laurent L, Ronveaux M, Doochmans P, Wanson JC (1979) Desmosomes and desmogenesis in the epidermis of calf muzzle. Biologie Cellulaire 34:137–152

    Google Scholar 

  • Leutgeb CH, Bandmann HJ, Breit R (1972) Handlinienmuster, Ichthyosis vulgaris und Dermatitis atopica. Arch Dermatol Forsch 244:354–363

    Article  CAS  PubMed  Google Scholar 

  • Mackenzie IC (1969) Ordered structure of the stratum corneum of mammalian skin. Nature 222:881–882

    Article  CAS  PubMed  Google Scholar 

  • Mackenzie IC (1972) The ordered structure of the stratum corneum of mammalian skin. In:Maibach H, Rovee D (eds) Epidermal wound healing. Year Book Medical Publishers, Chicago, pp 5–26

    Google Scholar 

  • Mackenzie IC, Zimmermann K, Peterson L (1981) The pattern of cellular organization of human epidermis. J Invest Dermatol 76:459–461

    Article  CAS  PubMed  Google Scholar 

  • Matoltsy AG, Parakkal PE (1965) Membrane-coating granules of keratinizing epithelia. J Cell Biol 24:297–307

    Article  CAS  PubMed  Google Scholar 

  • Maurer W, Pilgrim Ch, Wegener K, Hellweg S (1965) Messung der Dauer der DNS-Verdoppelung und der Generationszeit bei verschiedenen Zellarten von Maus und Ratte durch Doppelmarkierung mit H-3- und C-14-Thymidin. Radioaktive Isotopen in Klinik und Forschung 6:96–107

    Google Scholar 

  • Menton DN (1976) A minimum-surface mechanism to account for the organization of cells into columns in the mammalian epidermis. Am J Anat 145:1–22

    Article  CAS  PubMed  Google Scholar 

  • Montagna W, Parakkal PF (1974) The structure and function of skin, 3rd edn. Academic Press, New York

    Google Scholar 

  • Pappas G (1975) Junctions between cells. In:Weismann G, Claiborne R (eds) Cell mem¬branes. Hospital Practice, New York, pp 87–94

    Google Scholar 

  • Penneys NS, Fulton JE, Weinstein GD, Frost P (1970) Location of proliferating cells in human epidermis. Arch Dermatol 101:323–327

    Article  CAS  PubMed  Google Scholar 

  • Peracchia C (1980) Structural correlates of gap junction permeation. Int Rev Cytol 66:81–146

    Article  CAS  PubMed  Google Scholar 

  • Pilgrim C, Maurer W (1965) Autoradiographische Untersuchung über die Konstanz der DNS-Verdoppelungsdauer bei Zellarten von Maus und Ratte durch Doppelmarkierung mit 3H- und 14C-Thymidin. Exp Cell Res 37:187–199

    Article  Google Scholar 

  • Pinkus H (1952) Examination of the epidermis by the strip method:II. Biometric data on regeneration of the human epidermis. J Invest Dermatol 19:431–444

    Article  CAS  PubMed  Google Scholar 

  • Pinkus H, Hunter R (1966) The direction of the mitotic axis in human epidermis. Arch Dermatol 94:351–354

    Article  CAS  PubMed  Google Scholar 

  • Pinto da Silva P, Kachar B (1982) On tight junction structure. Cell 28:441–450

    Article  CAS  PubMed  Google Scholar 

  • Pitts JD (1981) How do animal cells communicate? Verh Dtsch Zool Ges 74:134–137

    CAS  Google Scholar 

  • Plewig G, Marples R (1970) Regional differences of cell sizes in the human stratum corneum:part I. J Invest Dermatol 54:13–21

    Article  CAS  PubMed  Google Scholar 

  • Porter D, Shuster S (1968) Epidermal renewal and amino acids in psoriasis and pityriasis rubra pilaris. Arch Dermatol 98:339–343

    Article  CAS  PubMed  Google Scholar 

  • Potten CS (1981) Cell replacement in epidermis (keratopoiesis) via discrete units of proliferation. Int Rev Cytol 69:271–318

    Article  CAS  PubMed  Google Scholar 

  • Pullmann H, Lennartz KJ, Steigleder GK (1974) In vitro examination of cell proliferation in normal and psoriatic epidermis, with special regard to diurnal variations. Arch Dermatol Forsch 250:177

    CAS  PubMed  Google Scholar 

  • Quastler H, Sherman FG (1959) Cell population kinetics in the intestinal epithelium of the mouse. Exp Cell Res 17:420–438

    Article  CAS  PubMed  Google Scholar 

  • Rothberg S, Crounse RG, Lee JL (1961) Glycin-14L incorporation into the proteins of normal stratum corneum and the abnormal stratum corneum of psoriasis. J Invest Dermatol 37:497–505

    Article  CAS  PubMed  Google Scholar 

  • Rowden G, Lewig MG, Sullivan AK (1977) Ia antigen expression on human epidermal Langerhans cells. Nature 268:247–248

    Article  CAS  PubMed  Google Scholar 

  • Rowe L, Dixon WJ, Forsythe A (1978) Mitosis in normal and psoriatic epidermis. Br J Dermatol 98:293–299

    Article  CAS  PubMed  Google Scholar 

  • Rupec M (1980) Mikroskopische und elektronenmikroskopische Anatomie der Haut. In:Korting GW (ed) Dermatologie in Praxis und Klinik, vol 1. Thieme, Stuttgart, pp 1.14–1.52

    Google Scholar 

  • Schell H, Schwarz W, Hornstein OP, Bernlochner W, Weghorn C (1981) Evidence of diurnal variation of human epidermal cell proliferation. Arch Dermatol Res 271:41–47

    Article  CAS  PubMed  Google Scholar 

  • Schumacher S (1931) Integument der Mammalier. In:Bolk L, Goeppert E, Kallus E, Lubosch W (eds) Handbuch der vergleichenden Anatomie der Wirbeltiere, vol 1. Urban & Schwarzenberg, Berlin, pp 449–504

    Google Scholar 

  • Silberberg-Sinakin I, Baer RL, Thorbecke GJ (1978) Langerhans cells:a review of their nature with emphasis on their immunologic functions. Prog Allergy 24:268–294

    CAS  PubMed  Google Scholar 

  • Squier C, Fejerskov O, Jepsen A (1978) The permeability of a keratinizing squamous epithelium in culture. J Anat 126:103–109

    CAS  PubMed  Google Scholar 

  • Staehelin LA (1974) Structure and function of intercellular junctions. Int Rev Cytol 39:191–283

    Article  CAS  PubMed  Google Scholar 

  • Staehelin LA, Hull BE (1978) Cell junctions between living cells. Sci Am 238:141–152

    Article  Google Scholar 

  • Stingl G, Wolff K (1982) Origin and function of Langerhans cells and their role in disease. In:Goos M, Christophers E (eds) Lymphoproliferative diseases of the skin. Springer, Berlin Heidelberg New York, pp 34–40

    Chapter  Google Scholar 

  • Stingl G, Wolff-Schreiner EC, Pichler W, Gschnait F, Knapp W, Wolff K (1977) Epidermal Langerhans cells bear Fc and C3 receptors. Nature 258:245–246

    Article  Google Scholar 

  • Stingl G, Katz SI, Clement L, Green I, Shevach EM (1978) Immunologic functions of Ia-bearing epidermal Langerhans cells. J Immunol 121:2005–2013

    CAS  PubMed  Google Scholar 

  • Streilein JW, Bergstresser PR (1981) Langerhans cell function dictates induction of contact hypersensitivity or unresponsiveness to DNFB in Syrian hamsters. J Invest Dermatol 77:272–277

    Article  CAS  PubMed  Google Scholar 

  • Toews GB, Bergstresser PR, Streilein JW (1980) Epidermal Langerhans cell density deter¬mines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 124:445–453

    CAS  PubMed  Google Scholar 

  • Watt F, Green H (1981) Involucrin synthesis is correlated with cell size in human epidermal cultures. J Cell Biol 90:738–742

    Article  CAS  PubMed  Google Scholar 

  • Weinstein GD, Frost P (1968) Abnormal cell proliferation in psoriasis. J Invest Dermatol 50:254–259

    CAS  PubMed  Google Scholar 

  • Weinstein GD, Frost P (1969) Cell proliferation in benign and malignant skin diseases in humans. Natl Cancer Inst Monogr 30:225–246

    CAS  PubMed  Google Scholar 

  • Weinstein GD, Van Scott EJ (1965) Autoradiographic analysis of turnover times in normal and psoriatic epidermis. J Invest Dermatol 45:257–262

    CAS  PubMed  Google Scholar 

  • Welsch U, Buchheim WC (1978) Zelljunktionen. Verh Anat Ges 72:199–215

    PubMed  Google Scholar 

  • Whitton J, Everall J (1973) The thickness of the epidermis. Br J Dermatol 89:467–476

    Article  CAS  PubMed  Google Scholar 

  • Wolff K (1972) The Langerhans cell. Curr Probl Dermatol 4:79–145

    CAS  PubMed  Google Scholar 

  • Wolff K, Schreiner E (1968) An electron microscopic study on the extraneous coat of keratinocytes and the intercellular space of the epidermis. J Invest Dermatol 51:418–432

    CAS  PubMed  Google Scholar 

  • Wright NA (1977) Cell population kinetics in human epidermis. Int J Dermatol 16:499

    Article  Google Scholar 

  • Wright NA (1981) A methodological approach to epidermopoiesis. In:Marks R, Christophers E (eds) The epidermis in disease. MTP Press, Lancaster, pp 139–153

    Google Scholar 

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Christophers, E., Schubert, C., Goos, M. (1989). The Epidermis. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin I. Handbook of Experimental Pharmacology, vol 87 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73797-8_1

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