Abstract
Oral immunization against typhoid fever with the attenuated S. typhi strain Ty 21a was introduced a few years ago by Germanier [5–8]. The Ty 21a strain is able to colonize and multiply in the small intestine for a limited period. Due to the defect of the enzyme uridine-diphosphate-galactose-4-epimerase the bacteria are destroyed by bacteriolysis after several generations, thus liberating many immunizing antigens. This in return results in the induction of cell-mediated [11], humoral [9] and local [4] immune response.
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References
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© 1989 Springer-Verlag Berlin Heidelberg
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Ambrosch, F., Hirschl, A., Kollaritsch, H., Kremsner, P., Rappold, E., Wiedermann, G. (1989). Immunologic Investigations with Oral Live Typhoid Vaccine TY 21A Strain. In: Steffen, R., Lobel, H., Haworth, J., Bradley, D.J. (eds) Travel Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73772-5_46
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DOI: https://doi.org/10.1007/978-3-642-73772-5_46
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