Toxic and Genotoxic Effects of SO2 or NOx Alone and in Combination with Carcinogenic N—Nitrosamines
The influence of common air pollutants SO2 or NOx on the genesis of tumors induced by chemical carcinogens has not yet been studied extensively. We may envisage the gases to act either inhibitory, additively or synergistically during the induction of tumors by carcinogens. Preliminary studies did show that lifelong SO2 inhalation in combination with benzo(a)pyrene yielded an increased tumor rate in experimental animals (1). Studies on the interaction between SO2 or NOx with carcinogenic N-nitrosamines however, have not been reported. Therefore, we are performing a study on the interplay between SO2 or NOx and carcinogens at various levels, including in vitro studies, as well as a long term bioassay, which is still underway.
KeywordsToxicity Lactate DMSO Hydrocarbon Alanine
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